Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Hannah J Uckelmann"'
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Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Autor: Hannah J. Uckelmann, Elena L. Haarer, Reina Takeda, Eric M. Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei Chen, Scott A. Armstrong
Publikováno v: Cancer Discovery. 13:746-765
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b913b2bcd54fa923346b6564cf152c03
https://doi.org/10.1158/2159-8290.cd-22-0366
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2
Supplementary Figures S1-S12 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Autor: Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
Supplementary Figure 1. NPM1c degradation leads to differentiation of OCI-AML3 cells.Supplementary Figure 2. NPM1c chromatin targets identified in OCI-AML3-NPM1c-FKBP12 cells and validated by targeted degradation.Supplementary Figure 3. Motif analysi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207cbdc40a0e1dbaa54f7c4f60899cba
https://doi.org/10.1158/2159-8290.22542664
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4
Data from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Autor: Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3a9e080791e492b2f41cab7a8ad41
https://doi.org/10.1158/2159-8290.c.6550015
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5
Supplementary Tables S1-S14 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Autor: Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
Table S1. Read normalized ratios of ChIPseq signal of untreated versus dTAG-13 treated OCI-AML3-NPM1c-FKBP12 cells.Table S2. Summary of NPM1c and NPM1 Chromatin Binding Targets.Table S3. Patient info for patient derived xenograft (PDX) models used.Ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4205e81f7ebdb51ed4160e09b7711959
https://doi.org/10.1158/2159-8290.22542658
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8
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Autor: Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda S. Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Delan Khalid, Jennifer A. Perry, Mark Wunderlich, Lina Benajiba, Yana Pikman, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Publikováno v: Cancer discovery. 12(7)
Leukemic blasts are immune cells gone awry. We hypothesized that dysregulation of inflammatory pathways contributes to the maintenance of their leukemic state and can be exploited as cell-intrinsic, self-directed immunotherapy. To this end, we applie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7711f13fafbbaf23d540489744c6acc
https://pubmed.ncbi.nlm.nih.gov/35791696
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9
Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts
Autor: Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Conway Saur, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Publikováno v: Cancer Research. 82:LB076-LB076
Leukemic blasts are immune cells gone awry. We thus hypothesized that dysregulation of inflammatory pathways can maintain a leukemic state. In contrast to traditional cancer immunotherapy, we exploited inflammatory signaling within AML blasts as cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8900373938e3e2cee9e71f5d4a2315
https://doi.org/10.1158/1538-7445.am2022-lb076
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10
Therapeutic targeting of preleukemia cells in a mouse model of
Autor: Hannah J, Uckelmann, Stephanie M, Kim, Eric M, Wong, Charles, Hatton, Hugh, Giovinazzo, Jayant Y, Gadrey, Andrei V, Krivtsov, Frank G, Rücker, Konstanze, Döhner, Gerard M, McGeehan, Ross L, Levine, Lars, Bullinger, George S, Vassiliou, Scott A, Armstrong
Publikováno v: Science (New York, N.Y.). 367(6477)
The initiating mutations that contribute to cancer development are sometimes present in premalignant cells. Whether therapies targeting these mutations can eradicate premalignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7180ea71d666e5b0c2c3ddecb2afd3f9
https://pubmed.ncbi.nlm.nih.gov/32033969
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