Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Hannah J, Gould"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Susan K. Vester, Anna M. Davies, Rebecca L. Beavil, Balraj S. Sandhar, Andrew J. Beavil, Hannah J. Gould, Brian J. Sutton, James M. McDonnell
Publikováno v:
Antibodies, Vol 12, Iss 4, p 75 (2023)
We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In this work, we complete the toolkit of human antibody isotypes
Externí odkaz:
https://doaj.org/article/d3b9137087384153b31f164c3220e2a6
Autor:
Line Ohm-Laursen, Hailong Meng, Kenneth B. Hoehn, Nima Nouri, Yue Jiang, Chris Clouser, Timothy G. Johnstone, Ron Hause, Balraj S. Sandhar, Nadine E. G. Upton, Elfy B. Chevretton, Raj Lakhani, Chris J. Corrigan, Steven H. Kleinstein, Hannah J. Gould
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal surfaces of the upper and lowe
Externí odkaz:
https://doaj.org/article/90d33209b9f84a22be9d4bd2b0aa8407
Autor:
Heather J. Bax, Holly Bowen, Rebecca L. Beavil, Raymond Chung, Malcolm Ward, Anna M. Davies, Tihomir S. Dodev, James M. McDonnell, Andrew J. Beavil, Brian J. Sutton, Hannah J. Gould
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Degranulation of mast cells and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells’ receptor-bound IgE antibodies. A widely used commercial monoclonal IgE antibody,
Externí odkaz:
https://doaj.org/article/43a4bcae3fcb47bd993a61cc883f32f7
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
IgE is secreted by plasma cells (PCs) and is central to allergic disease. Using an ex vivo tonsil B cell culture system, which mimics the Th2 responses in vivo, we have recently characterized the development pathway of human IgE-expressing PCs. In th
Externí odkaz:
https://doaj.org/article/da3d889f4da546bc8d590d847e27e32d
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Evaluation of FRalpha expression by tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38db7cb9edccc92a72b16204c6c84d78
https://doi.org/10.1158/0008-5472.22416014.v1
https://doi.org/10.1158/0008-5472.22416014.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Table of Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae24e70842a424500fbe06f48794886
https://doi.org/10.1158/0008-5472.22416008.v1
https://doi.org/10.1158/0008-5472.22416008.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bd38045ed7ffde480f7e6dc0d11ea
https://doi.org/10.1158/0008-5472.c.6509447.v1
https://doi.org/10.1158/0008-5472.c.6509447.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Description of additional experiments and procedures carried out in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e224e5f523a06cb1b657edf1f2f3944
https://doi.org/10.1158/0008-5472.22416011.v1
https://doi.org/10.1158/0008-5472.22416011.v1