Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration

Autor: Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Changwoo Lee, Benjamin Sanders, Paul J. Lee, Yangfei Xiang, Kimberly Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah H. Ro, Hyoungseok Ju, Clara Liao, Sofia Massaro Tieze, Frank Rigo, Paymaan Jafar-Nejad, Janghoo Lim

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)

Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in TARDBP, encoding transactive response DNA-binding protein 43 kDa (TDP-43), account for less than 1% of all ALS

Externí odkaz: https://doaj.org/article/3422673f0c504358a6b5a37951131574

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.

Autor: Tejwani L; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: leon.tejwani@yale.edu., Ravindra NG; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Computer Science, Yale University, New Haven, CT 06510, USA., Lee C; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA., Cheng Y; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA., Nguyen B; University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA., Luttik K; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA., Ni L; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA., Zhang S; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA., Morrison LM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA., Gionco J; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA., Xiang Y; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA., Yoon J; Yale College, New Haven, CT 06510, USA., Ro H; Yale College, New Haven, CT 06510, USA., Haidery F; Yale College, New Haven, CT 06510, USA., Grijalva RM; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA., Bae E; Yale College, New Haven, CT 06510, USA., Kim K; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA., Martuscello RT; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA., Orr HT; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Zoghbi HY; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA., McLoughlin HS; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA., Ranum LPW; Department of Molecular Genetics and Microbiology, Center for Neurogenetics, College of Medicine, Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA., Shakkottai VG; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Faust PL; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA., Wang S; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: siyuan.wang@yale.edu., van Dijk D; Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Computer Science, Yale University, New Haven, CT 06510, USA. Electronic address: david.vandijk@yale.edu., Lim J; Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT 06510, USA; Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: janghoo.lim@yale.edu.

Publikováno v: Neuron [Neuron] 2024 Feb 07; Vol. 112 (3), pp. 362-383.e15. Date of Electronic Publication: 2023 Nov 27.