Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hannah Guak"'
Autor:
Hannah Guak, Matthew Weiland, Alexandra Vander Ark, Lukai Zhai, Kin Lau, Mario Corrado, Paula Davidson, Ebenezer Asiedu, Batsirai Mabvakure, Shelby Compton, Lisa DeCamp, Catherine A. Scullion, Russell G. Jones, Sara M. Nowinski, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114506- (2024)
Summary: Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulate
Externí odkaz:
https://doaj.org/article/7912e7450a604454a8a5bc93c75f0f1a
Autor:
Hannah Guak, Ryan D. Sheldon, Ian Beddows, Alexandra Vander Ark, Matthew J. Weiland, Hui Shen, Russell G. Jones, Julie St-Pierre, Eric H. Ma, Connie M. Krawczyk
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Metabolic programming of the innate immune cells known as dendritic cells (DCs) changes in response to different stimuli, influencing their function. While the mechanisms behind increased glycolytic metabolism in response to inflammatory sti
Externí odkaz:
https://doaj.org/article/6f4583858e0a41b89b2cf4aaa9094f6e
Autor:
Tracey Avequin, Kin H. Lau, Althea N. Waldhart, Hannah Guak, Holly Dykstra, Connie Krawczyk, Ning Wu
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107163- (2023)
Summary: Obese individuals experience low grade inflammation initiated within their adipose tissue. However, the early events that lead to the release of these inflammatory factors from adipose tissue are poorly characterized. To separate glucose eff
Externí odkaz:
https://doaj.org/article/0368fc9a315e495197f489861e05bdad
Autor:
Hannah Guak, Sara Al Habyan, Eric H. Ma, Haya Aldossary, Maia Al-Masri, So Yoon Won, Thomas Ying, Elizabeth D. Fixman, Russell G. Jones, Luke M. McCaffrey, Connie. M. Krawczyk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The activation of dendritic cells (DC) is associated with a metabolic switch from oxidative to glycolytic metabolism. Here, the authors show that both strong and weak stimuli cause an immediate increase in glycolysis, but only strong stimuli induce l
Externí odkaz:
https://doaj.org/article/602bbe28597f4d06954fcdaaeb263744
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Epigenetics has widespread implications in a variety of cellular processes ranging from cell identity and specification, to cellular adaptation to environmental stimuli. While typically associated with heritable changes in gene expression, epigenetic
Externí odkaz:
https://doaj.org/article/831565f5182e4e93b425890159b30eba
Autor:
Giselle M. Boukhaled, Brendan Cordeiro, Genevieve Deblois, Vassil Dimitrov, Swneke D. Bailey, Thomas Holowka, Anisa Domi, Hannah Guak, Huai-Hsuan Clare Chiu, Bart Everts, Edward J. Pearce, Mathieu Lupien, John H. White, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1829-1837 (2016)
Pro-inflammatory signals provided by the microenvironment are critical to activate dendritic cells (DCs), components of the innate immune system that shape both innate and adaptive immunity. However, to prevent inappropriate immune activation, mechan
Externí odkaz:
https://doaj.org/article/8c33a8fcc6be440dae00c85bc3811e39
Autor:
Irazú Contreras, José A Estrada, Hannah Guak, Caroline Martel, Alborz Borjian, Benjamin Ralph, Marina T Shio, Sylvie Fournier, Connie M Krawczyk, Martin Olivier
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3202 (2014)
Leishmania parasites have the ability to modify macrophage signaling pathways in order to survive and multiply within its mammalian host. They are also known to invade other cells including neutrophils, fibroblasts and dendritic cells (DCs). DCs have
Externí odkaz:
https://doaj.org/article/032db9e4671247a5bd2d53ddb4f61051
Autor:
Hannah Guak, Matthew J Weiland, Alexandra R VanderArk, Lukai Zhai, Kin Lau, Batsi Mabvakure, Mario Corrado, Paula Davidson, Shelby Compton, Lisa DeCamp, Russell M Jones, Sara Nowinski, Connie M Krawczyk
The functional and phenotypic heterogeneity of dendritic cells (DCs) plays a crucial role in facilitating the development of diverse immune responses that are essential for providing host protection. We found that KDM5C, a histone lysine demethylase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19735fb6d1ff75d17a5457ce0b14ac09
https://doi.org/10.1101/2023.05.28.542441
https://doi.org/10.1101/2023.05.28.542441
Autor:
Hannah Guak, Connie M. Krawczyk
Publikováno v:
Immunology
Cell migration is an essential, energetically demanding process in immunity. Immune cells navigate the body via chemokines and other immune mediators, which are altered under inflammatory conditions of injury or infection. Several factors determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64345f717eaf3ecedfab0fd11c17aa54
https://doi.org/10.1111/imm.13260
https://doi.org/10.1111/imm.13260
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Epigenetics has widespread implications in a variety of cellular processes ranging from cell identity and specification, to cellular adaptation to environmental stimuli. While typically associated with heritable changes in gene expression, epigenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cf8498111f677945d63fd153d5e104
https://www.frontiersin.org/article/10.3389/fimmu.2019.01119/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.01119/full