Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hannah Gautrey"'
Publikováno v:
International Journal of Cell Biology, Vol 2013 (2013)
Overexpression of human epidermal growth factor receptor (HER-2) occurs in 20–30% of breast cancers and confers survival and proliferative advantages on the tumour cells making HER-2 an ideal therapeutic target for drugs like Herceptin. Continued d
Externí odkaz:
https://doaj.org/article/1ab04ec16c1c4c9eb1b4ae77edc99bee
Publikováno v:
Journal of Cancer Research and Clinical Oncology
In this study, two novel alternative splice variants of HER2, named HER2-PI9 and HER2-I12, were identified in breast cancer cell lines and breast tumour tissues. Whilst HER2-P19 arises from the inclusion of an 117 bp cassette-exon of intron 9 of HER2
Publikováno v:
Oncotarget
Overexpression of the HER2 receptor occurs in approximately 20% of breast cancer patients. HER2 positivity is associated with poor prognosis and aggressive tumour phenotypes, which led to rapid progress in HER2 targeted therapeutics and diagnostic te
Publikováno v:
RNA Biology. 14:536-543
The human epidermal growth factor receptor 2 (HER2)/receptor tyrosine-protein kinasebB-2 (ERBB2) is overexpressed in 20–30% of breast tumors leading to faster growing and more aggressive tumors. Alternative splicing generates a functionally distinc
Autor:
Hannah Gautrey, Anna-Lena Dittrich, DA Browell, Alison Tyson-Capper, Thomas W. J. Lennard, Claire Jackson
Publikováno v:
RNA Biology. 12:1139-1151
Overexpression of the oncogene HER2 occurs in 20-30% of invasive breast cancer and is associated with poor prognosis. A number of different splice variants of HER2 have been identified which produce functionally different proteins. Previously these s
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia. 19:253-270
The human epidermal growth factor receptor 2 (HER2) is a major player in the survival and proliferation of tumour cells and is overexpressed in up to 30 % of breast cancer cases. A considerable amount of work has been undertaken to unravel the activi
Publikováno v:
Genes & Nutrition
Selenium (Se) is essential for human health. Despite evidence that Se intake affects inflammatory responses, the mechanisms by which Se and the selenoproteins modulate inflammatory signalling, especially in the gut, are not yet defined. The aim of th
Publikováno v:
Biochimica et Biophysica Acta
Background Synthesis of selenoproteins such as glutathione peroxidases (GPx) requires a specific tRNA and a stem-loop structure in the 3′untranslated region (3′UTR) of the mRNA. A common single nucleotide polymorphism occurs in the GPX4 gene in a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(10):1935-1942
Pluripotent mouse embryonic stem (mES) cells derived from the blastocyst of the preimplantation embryo can be induced to differentiate in vitro along different cell lineages. However the molecular and cellular factors that signal and/or determine the
Autor:
Tomaz Curk, Alison Tyson-Capper, Andrew Best, Hannah Gautrey, David J. Elliott, Anshuli Razdan, Jas Chin, Elaine Hong
Publikováno v:
BioMed Research International, Vol 2015 (2015)
BioMed Research International
BioMed Research International
Scaffold attachment factor B1 (SAFB1) and SAFB2 proteins are oestrogen (ER) corepressors that bind to and modulate ER activity through chromatin remodelling or interaction with the basal transcription machinery. SAFB proteins also have an internal RN