Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hannah G Kelly"'
Publikováno v:
Expert Review of Vaccines, Vol 18, Iss 3, Pp 269-280 (2019)
Introduction: Immunization has been a remarkably successful public health intervention; however, new approaches to vaccine design are essential to counter existing and emerging infectious diseases which have defied traditional vaccination efforts to
Externí odkaz:
https://doaj.org/article/000b2a347cc64cee80cb5c44922ba5d0
Autor:
Hyon‐Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, The Austin Liver Transplant Perfusionist Group, Laura K Mackay, Claire L Gordon, Adam K Wheatley, Stephen J Kent, Jennifer A Juno
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV‐specific T‐cell memory in adults. Methods We
Externí odkaz:
https://doaj.org/article/401e8ba616ea4fe1967342f257bb2ce6
Autor:
Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241649 (2020)
Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine strains are matched with circulating strains. There is a critical need for developing "universal" vaccines that protect
Externí odkaz:
https://doaj.org/article/2b537a1b221b42809a82345d7d6347b1
Autor:
Hyon-Xhi Tan, Kathleen M. Wragg, Hannah G. Kelly, Robyn Esterbauer, Benjamin J. Dixon, Jillian S. Y. Lau, Katie L. Flanagan, Carolien E. van de Sandt, Katherine Kedzierska, James H. McMahon, Adam K. Wheatley, Jennifer A. Juno, Stephen J. Kent
Publikováno v:
The Journal of Immunology. 208:2267-2271
Understanding the generation of immunity to SARS-CoV-2 in lymphoid tissues draining the site of infection has implications for immunity to SARS-CoV-2. We performed tonsil biopsies under local anesthesia in 19 subjects who had recovered from SARS-CoV-
Autor:
Henry J. Sutton, Brian J. Parker, Mariah Lofgren, Cherrelle Dacon, Deepyan Chatterjee, Xin Gao, Hannah G. Kelly, Robert A. Seder, Joshua Tan, Azza H. Idris, Teresa Neeman, Ian A. Cockburn
SummaryLong-lived plasma cells (PCs) secrete antibodies that can provide sustained immunity against infection. It has been proposed that high affinity cells are preferentially selected into this compartment, potentiating the immune response. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a523a98e77df49cfa3bf9033d96ff92
https://doi.org/10.1101/2023.04.13.536825
https://doi.org/10.1101/2023.04.13.536825
Autor:
Wen Shi Lee, Adam K. Wheatley, Jennifer A Juno, Isaac M Barber-Axthelm, Robyn Esterbauer, Kathleen M. Wragg, Anne Gibbon, Hyon-Xhi Tan, Stephen J. Kent, Hannah G. Kelly
Publikováno v:
The Journal of Immunology. 207:735-744
Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates are a key preclinical animal model for human vaccine development, allowing both lymph node (LN) and circulating immune
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Autor:
Allen C. Cheng, Francesca L Mordant, Katherine Kedzierska, Keith J. Chappell, Daniel Watterson, Brendon Y. Chua, Hannah G. Kelly, Suzanne K. Shoffner, Jane Crowe, Carolien E. van de Sandt, Melissa M. Lemke, Naphak Modhiran, Bruce D. Wines, Fatima Amanat, Thi H. O. Nguyen, Adam K. Wheatley, Marios Koutsakos, Wen Shi Lee, Hyon-Xhi Tan, Luca Hensen, Kelly B. Arnold, David C. Jackson, Paul R. Young, Amy W. Chung, Paul V. Licciardi, Katie L. Flanagan, Shidan Tosif, Samantha K Davis, Louise C. Rowntree, Chinn Yi Wong, Jennifer A Juno, Stephen J. Kent, Nigel W Crawford, P. Mark Hogarth, Philip Sutton, Melanie R Neeland, Robyn Esterbauer, Kevin J. Selva, Florian Krammer, Denise L. Doolan, Christina Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12(1):2037
Nature Communications
Nature communications, 12(1). Nature Publishing Group
Nature Communications, 12(1):2037
Nature Communications
Nature communications, 12(1). Nature Publishing Group
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand su
Autor:
Jennifer A Juno, Daniel S. Layton, Stephen J. Kent, Hannah G. Kelly, Paul G. Whitney, Adam K. Wheatley, Julius Wong, Hyon-Xhi Tan, Ian G. Barr, Wenbo Jiang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the pre‐clinical assessment of vaccines. However, relatively little is known about the ferret immune system, due in part t
Autor:
C. Jane Batten, Kathleen M. Wragg, Nichollas E. Scott, Wai-Hong Tham, Francesca L Mordant, Jennifer A Juno, Phillip Pymm, Kanta Subbarao, Melanie H. Dietrich, Wen Shi Lee, Hannah G. Kelly, Miles P. Davenport, Nicholas A Gherardin, Stephen J. Kent, Dale I. Godfrey, Helen E Kent, Robyn Esterbauer, Arnold Reynaldi, Hyon-Xhi Tan, Adam K. Wheatley
Publikováno v:
Nature Medicine
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development efforts1-3, most targeting the viral 'spike' glycoprotein (S). S localizes on the virion surface and mediates recognition
Autor:
Jiacheng Zhao, Changkui Fu, Hui Peng, Ye Yu, Felicity Y. Han, Trent M. Woodruff, Andrew K. Whittaker, Cyrille Boyer, Xiao Tan, Vinod Kumar, Weizhi Xu, Hannah G. Kelly, Stephen J. Kent, Debra J. Searles, Sheilajen Alcantara, Cheng Zhang, Baris Demir
Publikováno v:
Angewandte Chemie International Edition. 59:4729-4735
The conjugation of hydrophilic low-fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability and solubility, and extending their pharmacokinetics. Recent concerns over the immunogenicity of