Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannah E. Opalko"'
Publikováno v:
eLife, Vol 8 (2019)
Control of cell size requires molecular size sensors that are coupled to the cell cycle. Rod-shaped fission yeast cells divide at a threshold size partly due to Cdr2 kinase, which forms nodes at the medial cell cortex where it inhibits the Cdk1-inhib
Externí odkaz:
https://doaj.org/article/19df48cfe611405fa29edd29431fa3ff
Autor:
Kim H, Hannah E. Opalko, Archana Singh, Michael-Christopher Keogh, Vargas-Garcia Ca, Kristi E. Miller, James B. Moseley
Publikováno v:
The Journal of cell biology. 221(2)
Fission yeast cells prevent mitotic entry until a threshold cell surface area is reached. The protein kinase Cdr2 contributes to this size control system by forming multiprotein nodes that inhibit Wee1 at the medial cell cortex. Cdr2 node anchoring a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7543aa7c5684bf9d50e7a6a3320d41
https://pubmed.ncbi.nlm.nih.gov/34958661
https://pubmed.ncbi.nlm.nih.gov/34958661
Autor:
James B. Moseley, Lauren E. Cressey, Arminja N. Kettenbach, Hannah E. Opalko, Joseph O. Magliozzi, Marielle Brady, Jack Sears
Publikováno v:
The Journal of Cell Biology
Magliozzi et al. show that fission yeast cell polarity kinase Pak1 regulates cytokinesis. Through a phosphoproteomic screen and subsequent mutant analysis, their work uncovers direct targets and mechanisms for Pak1 activity during cell division.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5b27333e9497206fddcd402053db5a
http://europepmc.org/articles/PMC7401808
http://europepmc.org/articles/PMC7401808
Publikováno v:
Molecular Biology of the Cell
To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1. SAD family protein kinases regulate Wee1 signaling in yeast and humans. InS. pombe, two SAD kinases (Cdr1/Nim1 and Cdr2) act as upstream inhibitors of Wee1. Previous studies fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3434b4f7fb6d84e9b2c7974f3162eb10
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Control of cell size requires molecular size sensors that are coupled to the cell cycle. Rod-shaped fission yeast cells divide at a threshold size partly due to Cdr2 kinase, which forms nodes at the medial cell cortex where it inhibits the Cdk1-inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c367cb555ecf89e4552b5c527f833f84
https://doi.org/10.7554/elife.46003
https://doi.org/10.7554/elife.46003
Publikováno v:
The Journal of Cell Biology
Cells turn off the mitotic inhibitor Wee1 to enter into mitosis. Allard et al. show how cell growth progressively inhibits fission yeast Wee1 through dynamic bursts of localization to cortical node structures that contain Wee1 inhibitory kinases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435243450faa317778d0a15f014943a7
https://pubmed.ncbi.nlm.nih.gov/29514920
https://pubmed.ncbi.nlm.nih.gov/29514920
Cell size control requires mechanisms that link cell growth with Cdk1 activity. In fission yeast, the protein kinase Cdr2 forms cortical nodes that include the Cdk1 inhibitor Wee1, along with the Wee1-inhibitory kinase Cdr1. We investigated how nodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0de2e26987df90b6a031a2ad9021b5
https://doi.org/10.1101/195628
https://doi.org/10.1101/195628
Autor:
James B. Moseley, Hannah E. Opalko
Publikováno v:
The Journal of biological chemistry. 292(45)
Environmental conditions modulate cell cycle progression in many cell types. A key component of the eukaryotic cell cycle is the protein kinase Wee1, which inhibits the cyclin-dependent kinase Cdk1 in yeast through human cells. In the fission yeast S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6683ab792e29e791bf2649bc8f58a5
https://pubmed.ncbi.nlm.nih.gov/28924043
https://pubmed.ncbi.nlm.nih.gov/28924043
Autor:
Surachai Supattapone, Sonja E. DiGregorio, Ashley A. Zurawel, Martin L. Duennwald, Hannah E. Opalko, James B. Moseley, Ruth Kabeche, Kartikeya M. Menon, Lin Deng
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
mBio
mBio, Vol 7, Iss 5, p e01367-16 (2016)
mBio
mBio, Vol 7, Iss 5, p e01367-16 (2016)
Proteins containing polyglutamine (polyQ) regions are found in almost all eukaryotes, albeit with various frequencies. In humans, proteins such as huntingtin (Htt) with abnormally expanded polyQ regions cause neurodegenerative diseases such as Huntin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec3b8ba5b505ac297bdb1d74a2956ca
https://journals.asm.org/doi/10.1128/mBio.01367-16
https://journals.asm.org/doi/10.1128/mBio.01367-16