Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hannah E. Lou"'
Autor:
Matthew E. Brown, Ying Zhou, Brian E. McIntosh, Ian G. Norman, Hannah E. Lou, Mitch Biermann, Jeremy A. Sullivan, Timothy J. Kamp, James A. Thomson, Petros V. Anagnostopoulos, William J. Burlingham
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1175-1183 (2018)
Summary: Here, we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). Conventional humanized mouse models are made by engrafti
Externí odkaz:
https://doaj.org/article/081f57c2cd484249a05a76cb93c1caa6
Autor:
Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, Erik J. Sontheimer
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previ
Externí odkaz:
https://doaj.org/article/235e55b82aeb4666b874a7f3a5f87dce
Autor:
Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda M. Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern
Publikováno v:
Cell Reports. 40:111363
Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently in malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1-deficient Schwann cells. To define the oncogenic mechanisms underlying PRC2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1351074c631e3b9614f7a1b3c17cd0
https://doi.org/10.1016/j.celrep.2022.111363
https://doi.org/10.1016/j.celrep.2022.111363
Autor:
Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern
Publikováno v:
Cancer Research. 82:701-701
Objective: Recurrent mutations in the polycomb repressive complex 2 (PRC2) occur in ~80% of malignant peripheral nerve sheath tumors (MPNST), which originate from NF1-deficient Schwann cells. In MPNST, PRC2 loss results in a diverse set of transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6582c5e6acb60ffcde31b4e7705423f7
https://doi.org/10.1158/1538-7445.am2022-701
https://doi.org/10.1158/1538-7445.am2022-701
Autor:
Xiyuan Zhang, Carly M. Sayers, Zhihui Liu, Hannah E. Lou, Haiyan Lei, Vishaka Gopalan, Prashant Chittiboina, Catherine Paige Jones, Brigitte C. Widemann, Michael C. Kelly, Marielle E. Yohe, Carol J. Thiele, John F. Shern, Sridhar Hannenhalli
Publikováno v:
SSRN Electronic Journal.
Genetic alterations that result in the dysregulation of polycomb repressive complex 2 (PRC2) are common features of multiple cancer types. Loss-of-function mutations in the PRC2 genes, SUZ12 or EED, occur at high frequency in malignant peripheral ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f126043ad8b1251336107f4cf09994
https://doi.org/10.2139/ssrn.3919932
https://doi.org/10.2139/ssrn.3919932
Autor:
Xiyuan Zhang, Haiyan Lei, Hannah E. Lou, Marielle E. Yohe, Brigitte C. Widemann, Carol J. Thiele, Zhihui Liu, Jack F. Shern
Publikováno v:
Cancer Research. 80:3898-3898
Background: Malignant peripheral nerve sheath tumors (MPNST) are aggressive and highly metastatic soft tissue sarcomas that lack effective treatment. Loss of the functional polycomb repressive complex 2 (PRC2) through genetic alterations in its core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de2baa4a4f5a1a57a99faa63443a5add
https://doi.org/10.1158/1538-7445.am2020-3898
https://doi.org/10.1158/1538-7445.am2020-3898
Autor:
Timothy J. Kamp, Jeremy A. Sullivan, Ying Zhou, Mitch Biermann, Brian E. McIntosh, James A. Thomson, William J. Burlingham, Petros V. Anagnostopoulos, Hannah E. Lou, Ian G. Norman, Matthew E. Brown
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 4, Pp 1175-1183 (2018)
Stem Cell Reports, Vol 10, Iss 4, Pp 1175-1183 (2018)
Summary Here, we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). Conventional humanized mouse models are made by engraftin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44589f90cc93f5799ccb57f657f0b904
https://pubmed.ncbi.nlm.nih.gov/29576539
https://pubmed.ncbi.nlm.nih.gov/29576539