Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hannah E. Dobson"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Despite significant advances in immune checkpoint blockade (ICB), immunosuppression mediated by tumor-associated myeloid cells (TAMCs) poses a major barrier to cancer immunotherapy. In addition, while immunogenic cell death (ICD) provides a
Externí odkaz:
https://doaj.org/article/bdd41061df664c3ba88533a3b50f245e
Autor:
Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson, Marcel Wüthrich, Bruce Klein
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104934- (2022)
Summary: Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory cells that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4+T cells re
Externí odkaz:
https://doaj.org/article/79de89eeb6af4dca8e37a56c8143f1ce
Autor:
Marcel Wüthrich, Hannah E. Dobson, Cleison Ledesma Taira, Uju Joy Okaa, Lucas dos Santos Dias, Marcos Isidoro-Ayza, Nikolai Petrovsky, Bruce S. Klein
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The development of effective vaccines against fungal infections requires the induction of protective, pathogen-specific cell-mediated immune responses. Here, we asked whether combination adjuvants based on delta inulin (Advax) formulated wit
Externí odkaz:
https://doaj.org/article/56e44bbade2946e58ea31d694fa2764b
Autor:
Tonie E. Rocke, Brock Kingstad-Bakke, Marcel Wüthrich, Ben Stading, Rachel C. Abbott, Marcos Isidoro-Ayza, Hannah E. Dobson, Lucas dos Santos Dias, Kevin Galles, Julia S. Lankton, Elizabeth A. Falendysz, Jeffrey M. Lorch, J. Scott Fites, Jaime Lopera-Madrid, J. Paul White, Bruce Klein, Jorge E. Osorio
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American hibernating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS
Externí odkaz:
https://doaj.org/article/6d8f3b480a084707931474796061c861
Autor:
Cheng Xu, Hannah E. Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W. Tai, Yu Leo Lei, James J. Moon
Publikováno v:
Journal of Controlled Release. 357:84-93
Autor:
Marisa E, Aikins, You, Qin, Hannah E, Dobson, Alireza Hassani, Najafabadi, Kexing, Lyu, Yao, Xu, Ying, Xin, Anna, Schwendeman, Max S, Wicha, Alfred E, Chang, Qiao, Li, James J, Moon
Publikováno v:
Journal of Controlled Release. 351:872-882
One of the major reasons for poor cancer outcomes is the existence of cancer stem cells (CSCs). CSCs are a small subpopulation of tumor cells that can self-renew, differentiate into the majority of tumor cells, and maintain tumorigenicity. As CSCs ar
Publikováno v:
Oncotarget. 12:1850-1858
Integrins mediate cell-cell interactions and communication with the extracellular matrix (ECM). These transmembrane protein receptors allow binding between a cell and its surroundings, initiating a breadth of intracellular signaling resulting in prol
Autor:
Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson, Marcel Wüthrich, Bruce Klein
Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory cells that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4+T cells recalled to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ba71e432defbbb1e00284f27998988
https://doi.org/10.1101/2022.06.23.497400
https://doi.org/10.1101/2022.06.23.497400
Autor:
Lucas Dos Santos Dias, Marcel Wüthrich, Thamotharampillai Dileepan, Hannah E. Dobson, Elaine M. Kohn, Scott J. Fites, Gary R. Ostroff, Gregory C. Kujoth, Ambily Abraham, Darin L. Wiesner, Bruce S. Klein
Publikováno v:
Mucosal immunology
Priming at the site of natural infection typically elicits a protective T cell response against subsequent pathogen encounter. Here, we report the identification of a novel fungal antigen that we harnessed for mucosal vaccination and tetramer generat
Autor:
Elaine M. Kohn, Lucas dos Santos Dias, Hannah E. Dobson, Xin He, Huafeng Wang, Bruce S. Klein, Marcel Wüthrich
Publikováno v:
J Immunol
Homotypic signaling lymphocyte activation molecule (SLAM) receptor–ligand cell surface interactions between myeloid and lymphoid cells regulate innate and adaptive immune responses. In this article, we report that SLAMF1 is indispensable for host r