Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hannah E Peck"'
Autor:
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012345 (2024)
The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventional approac
Externí odkaz:
https://doaj.org/article/ff2b71e5f2c14cc889ed30f7de84cd2e
Autor:
Huanzhen Ni, Marine Z. C. Hatit, Kun Zhao, David Loughrey, Melissa P. Lokugamage, Hannah E. Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.
Externí odkaz:
https://doaj.org/article/a3a05515d75242a7919700c5dcde3bf7
Autor:
Daryll Vanover, Chiara Zurla, Hannah E. Peck, Nichole Orr‐Burks, Jae Yeon Joo, Jackelyn Murray, Nathan Holladay, Ryan A. Hobbs, Younghun Jung, Lorena C. S. Chaves, Laura Rotolo, Aaron W. Lifland, Alicia K. Olivier, Dapeng Li, Kevin O. Saunders, Gregory D. Sempowski, James E. Crowe Jr., Barton F. Haynes, Eric R. Lafontaine, Robert J. Hogan, Philip J. Santangelo
Publikováno v:
Advanced Science, Vol 9, Iss 34, Pp n/a-n/a (2022)
Abstract Despite the success of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vaccines, there remains a clear need for new classes of preventatives for respiratory viral infections due to vaccine hesitancy, lack of sterilizing im
Externí odkaz:
https://doaj.org/article/ecf03feec815403cb0b70263213107be
Autor:
Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro J. Da Silva Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern, Kalina Paunovska, Hannah E. Peck, Jinwhan Kim, Manaka Sato, Jacob I. Feldman, Michael-Alexander Rivera, Ana Cristian, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Chemistry. 15:508-515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d411f66312b8f3b3c4db27594a5df3e
https://doi.org/10.1038/s41557-023-01138-9
https://doi.org/10.1038/s41557-023-01138-9
Autor:
Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, David Loughrey, Alejandro J. Da Silva Sanchez, Huanzhen Ni, Marine Z. C. Hatit, Melissa P. Lokugamage, Yanina Kuzminich, Hannah E. Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:871-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5beb6a4306e31071e6b7bc2c2cb6f282
https://doi.org/10.1038/s41565-022-01146-9
https://doi.org/10.1038/s41565-022-01146-9
Autor:
Jared P. Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E. Peck, Ryan A. Hobbs, Jay A. Wroe, Chiara Zurla, Charles A. Gersbach, Philip J. Santangelo
Publikováno v:
ACS Nano. 16:5660-5671
Programmable control of gene expression via nuclease-null Cas9 fusion proteins has enabled the engineering of cellular behaviors. Here, both transcriptional and epigenetic gene activation via synthetic mRNA and lipid nanoparticle delivery was demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb63f4aa548534dcd9305f31eb9aa60
https://doi.org/10.1021/acsnano.1c10631
https://doi.org/10.1021/acsnano.1c10631
Autor:
Marine Z. C. Hatit, Melissa P. Lokugamage, Curtis N. Dobrowolski, Kalina Paunovska, Huanzhen Ni, Kun Zhao, Daryll Vanover, Jared Beyersdorf, Hannah E. Peck, David Loughrey, Manaka Sato, Ana Cristian, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:310-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff65c7ba59890ec94d1cb948b4e910f
https://doi.org/10.1038/s41565-021-01030-y
https://doi.org/10.1038/s41565-021-01030-y
Autor:
Jared Beyersdorf, YongTae Kim, Huanzhen Ni, James E. Dahlman, Elisa Schrader Echeverri, Daryll Vanover, Marine Z. C. Hatit, Jeong-Kee Yoon, Melissa P. Lokugamage, Philip J. Santangelo, Hannah E. Peck, Laura Rotolo
Publikováno v:
Nature Biomedical Engineering. 5:1059-1068
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b20432f2dcecc6f5da64dfd78d16f3
https://doi.org/10.1038/s41551-021-00786-x
https://doi.org/10.1038/s41551-021-00786-x
Autor:
Philip J. Santangelo, Hannah E. Peck, Laura Rotolo, Pooja M. Tiwari, Eric R. Lafontaine, Swapnil Bawage, Margo A. Brinton, M. G. Finn, Nicholas C. Bruno, Robert Hincapie, Daryll Vanover, Jackelyn Murray, Bob Vanderheyden, Emmeline L. Blanchard, Jared Beyersdorf, Robert J. Hogan, Heena Sadhwani, Chiara Zurla, Frank Michel
Publikováno v:
Nature Biotechnology
Cas13a has been used to target RNA viruses in cell culture, but efficacy has not been demonstrated in animal models. In this study, we used messenger RNA (mRNA)-encoded Cas13a for mitigating influenza virus A and severe acute respiratory syndrome cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e555857aca3fcaa07b9a0739554aa781
https://doi.org/10.1038/s41587-021-00822-w
https://doi.org/10.1038/s41587-021-00822-w
Autor:
Lena Gamboa, Ali H. Zamat, Daryll Vanover, Chloé A. Thiveaud, Hannah E. Peck, Hathaichanok Phuengkham, Anirudh Sivakumar, Adrian M. Harris, Shreyas N. Dahotre, Fang-Yi Su, Philip J. Santangelo, Gabriel A. Kwong
CAR T cell immunotherapy relies on CAR targeting of tumor-associated antigens, yet heterogenous antigen expression, interpatient variation, and off-tumor expression by healthy cells remain barriers. Here, we develop synthetic antigens to sensitize so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3dbbada2c580ebfbc394cd30ecd7998
https://doi.org/10.1101/2021.12.11.472238
https://doi.org/10.1101/2021.12.11.472238
