Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hannah E, Stutzman"'
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M Loupe, Vanessa C Wheeler, Hannah E Stutzman, Ben Kleinstiver, Jong-Min Lee
Publikováno v:
eLife, Vol 12 (2024)
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://doaj.org/article/be3156c656d24edfa4a721019c3ab21e
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver
Publikováno v:
Nature Biotechnology. 41:409-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76210e861acf8181c3af196e0bc046a
https://doi.org/10.1038/s41587-022-01492-y
https://doi.org/10.1038/s41587-022-01492-y
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M. Loupe, Vanessa C. Wheeler, Hannah E. Stutzman, Benjamin P. Kleinstiver, Jong-Min Lee
Publikováno v:
bioRxiv
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95978ca0d623b50e7eb2b21c91a6b50
https://doi.org/10.1101/2023.04.28.538700
https://doi.org/10.1101/2023.04.28.538700
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Linyuan Ma, G. Brett Robb, Benjamin P. Kleinstiver
While restriction enzymes (REs) remain the gold-standard for manipulating DNA in vitro, they have notable drawbacks including a dependence on short binding motifs that constrain their ability to cleave DNA substrates. Here we overcome limitations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90883b1070d6818cc6bf7499320c9c40
https://doi.org/10.1101/2022.01.11.474553
https://doi.org/10.1101/2022.01.11.474553
Autor:
Kathleen A, Christie, Jimmy A, Guo, Rachel A, Silverstein, Roman M, Doll, Megumu, Mabuchi, Hannah E, Stutzman, Jiecong, Lin, Linyuan, Ma, Russell T, Walton, Luca, Pinello, G Brett, Robb, Benjamin P, Kleinstiver
Publikováno v:
Nature biotechnology.
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific motifs, whereas wild-type CRISPR-Cas9 or CRISPR-Cas12 nucleases require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd132efe9eb805fbd83df8e578a7a56
https://pubmed.ncbi.nlm.nih.gov/36203014
https://pubmed.ncbi.nlm.nih.gov/36203014
Autor:
Christie, Kathleen A., Guo, Jimmy A., Silverstein, Rachel A., Doll, Roman M., Mabuchi, Megumu, Stutzman, Hannah E., Lin, Jiecong, Ma, Linyuan, Walton, Russell T., Pinello, Luca, Robb, G. Brett, Kleinstiver, Benjamin P.
Publikováno v:
Nature Biotechnology; Mar2023, Vol. 41 Issue 3, p409-416, 8p