Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hannah Dou"'
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56bfd1df312774368ff5b90efcd7cc
https://doi.org/10.1021/acs.jmedchem.9b01310
https://doi.org/10.1021/acs.jmedchem.9b01310
Autor:
Christine Sastri, Noelle Javier, Ryan Wurz, J. Russell Lipford, Hannah Dou, Mei-Chu Lo, Victor J. Cee, John McCarter, Ken Dellamaggiore, Dane Mohl
Publikováno v:
Journal of Medicinal Chemistry. 61:453-461
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc44534d76887770e2aaa9542e5fc1
https://doi.org/10.1021/acs.jmedchem.6b01781
https://doi.org/10.1021/acs.jmedchem.6b01781
Autor:
Hannah Dou, Songli Wang, Hilary Plake Beck, Hantao Liu, Steven H. Olson, Toni Williamson, Philip Roveto, James J. S. Treanor, Frank Kayser, Guifen Xu, Ji Ma, Brian M. Fox, Qingwen Cheng, Lixia Jin
Publikováno v:
Journal of Medicinal Chemistry. 58:5256-5273
A high-throughput screen resulted in the discovery of benzoxazepine 1, an EP2 antagonist possessing low microsomal stability and potent CYP3A4 inhibition. Modular optimization of lead compound 1 resulted in the discovery of benzoxazepine 52, a molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef41a2643586df11c417b506976b81a0
https://doi.org/10.1021/acs.jmedchem.5b00567
https://doi.org/10.1021/acs.jmedchem.5b00567
Autor:
Hu Ye, Tim Kazules, Ji Ma, Dianna Lester-Zeiner, Essa Hu, Santosh Talreja, Carl Davis, Charlie Glaus, Oliver R. Thiel, Ning Chen, Geraldine Hill Della Puppa, James J. S. Treanor, Shannon Rumfelt, Hui Hannah Dou, Roxanne Kunz, David C. Immke, Jessica Able, Jennifer R. Allen, Silke Miller, Xiaoning Zhao, Hang Chen, Jianxia Shi, Jamie Wong, Toni Williamson, Christopher Biorn, Amy Porter, Klaus Michelsen, Ada Chen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Phosphodiesterase 10A (PDE10A) inhibitors have therapeutic potential for the treatment of psychiatric and neurologic disorders, such as schizophrenia and Huntington's disease. One of the key requirements for successful central nervous system drug dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2114c0263395e74897b10174822cf2a
https://pubmed.ncbi.nlm.nih.gov/25502803
https://pubmed.ncbi.nlm.nih.gov/25502803
Autor:
Brian M. Fox, Hilary P. Beck, PhilipM. Roveto, Frank Kayser, Qingwen Cheng, Hannah Dou, Toni Williamson, James Treanor, Hantao Liu, Lixia Jin, Guifen Xu, Ji Ma, Songli Wang, Steven H. Olson
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 13, p5256-5273, 18p
Autor:
Aljaar, Nayyef, Ibrahim, Mohammad M., Younes, Eyad A., Al‐Noaimi, Mousa, Abu‐Safieh, Kayed A., Ali, Basem F., Kant, Kamal, Al‐Zaqri, Nabil, Sengupta, Ragini, Malakar, Chandi C.
Publikováno v:
Asian Journal of Organic Chemistry; Apr2023, Vol. 12 Issue 4, p1-26, 26p
Autor:
Elle Kennedy
Ele é um atleta talentoso, mas vai ter de melhorar muito as suas jogadas… Segundo volume da série Off-Campus, uma das coleções de maior sucesso do género New Adult. John Logan parece levar uma vida perfeita. Com um enorme talento para o hóque
Autor:
Elle Kennedy
Um jogador de múltiplos recursos, que agora terá de apostar mais alto... Série Off-Campus. John Logan, universitário, pode ter as mulheres que quiser. Para esta estrela do hóquei, a vida é um desfile de festas e engates. No entanto, por trás d
Autor:
Louisa May Alcott
As quatro irmãs March são muito diferentes entre si. A já adulta Meg; Jo, a moleca impulsiva; Beth, tímida e introvertida; e Amy, a precoce caçula. Mas com o pai longe de casa, na guerra, e a mãe trabalhando para sustentar a família, elas prec