Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hannah D. G. Fiji"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26135 (2011)
Small molecule inhibitors of protein geranylgeranyltransferase-I (GGTase-I) provide a promising type of anticancer drugs. Here, we first report the identification of a novel tetrahydropyridine scaffold compound, P61-E7, and define effects of this com
Externí odkaz:
https://doaj.org/article/b8a9338ed6314046ab16f6414e1f8b7c
Autor:
Ohyun Kwon, Georg W. Otto, Hannah D. G. Fiji, Kevin Mouillesseaux, Zhiming Wang, Robert Geisler, Sape S. Kinderman, Jayoung Choi, Jau-Nian Chen
Publikováno v:
Development-The Company of Biologists, 138(6), 1173-1181. Company of Biologists Ltd
Arterial and venous endothelial cells exhibit distinct molecular characteristics at early developmental stages. These lineage-specific molecular programs are instructive to the development of distinct vascular architectures and physiological conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8923309289f6a5a6f2ccf32f8a1f8b05
https://doi.org/10.1242/dev.054049
https://doi.org/10.1242/dev.054049
Autor:
Lai Chan, Ohyun Kwon, Fuyuhiko Tamanoi, Hannah D. G. Fiji, Lea Guo, Masaru Watanabe, Dennis J. Slamon, Sape S. Kinderman
Publikováno v:
Journal of Biological Chemistry. 283:9571-9579
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these modifications. In this work, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab3e031d2e40ffb6ce98d57802b5b6
https://doi.org/10.1074/jbc.m706229200
https://doi.org/10.1074/jbc.m706229200
Autor:
Joshua I. Goldhaber, Sarah Franklin, James K. Gimzewski, Huanqi Zhu, Johann Schredelseker, György Hajnóczky, Ohyun Kwon, Atsushi Nakano, Fei Lu, Kevin Wang, Haruko Nakano, Hirohito Shimizu, Thomas M. Vondriska, Junichi Nakai, Amy Ehrlich, Kui Lu, Billy Lin, Cheng Tian, Adam Z. Stieg, Jau-Nian Chen, Hannah D. G. Fiji, Jie Huang, Shamim Naghdi
Publikováno v:
eLife, vol 4, iss 4
eLife
eLife, Vol 4 (2015)
eLife
eLife, Vol 4 (2015)
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca2+ handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca2+ extrusion de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79abb65721055d79c64398aca364b890
https://escholarship.org/uc/item/4863d036
https://escholarship.org/uc/item/4863d036
Autor:
Sabrina Castellano, Fuyuhiko Tamanoi, Masaru Watanabe, Ohyun Kwon, Sape S. Kinderman, Hannah D. G. Fiji, Pablo De Leon
Publikováno v:
Journal of the American Chemical Society. 129:5843-5845
Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2ce14754fb2d0e78c0dbb55b1a077
https://doi.org/10.1021/ja070274n
https://doi.org/10.1021/ja070274n
Publikováno v:
Molecular cancer therapeutics. 8(5)
Protein geranylgeranyltransferase-I (GGTase-I) catalyzes protein geranylgeranylation, which is critical for the function of proteins such as Rho, Rac, and Ral. We previously identified several small-molecule inhibitors of GGTase-I from an allenoate-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d0d68ce8a18222f5f9d8d9622a61ba
https://pubmed.ncbi.nlm.nih.gov/19417142
https://pubmed.ncbi.nlm.nih.gov/19417142
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26135 (2011)
PLoS ONE
PLoS ONE
Small molecule inhibitors of protein geranylgeranyltransferase-I (GGTase-I) provide a promising type of anticancer drugs. Here, we first report the identification of a novel tetrahydropyridine scaffold compound, P61-E7, and define effects of this com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7198357fd84aaf90d9297e61d3131d8
https://doi.org/10.1371/journal.pone.0026135
https://doi.org/10.1371/journal.pone.0026135