Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hannah C. Timmins"'
Autor:
Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-tr
Externí odkaz:
https://doaj.org/article/2c68d9d7c95a4ee5840e68ef1badc7f5
Autor:
Fawaz Mayez Mahfouz, Susanna B. Park, Tiffany Li, Hannah C. Timmins, Lisa G. Horvath, Michelle Harrison, Peter Grimison, Tracy King, David Goldstein, David Mizrahi
Publikováno v:
Clinical Autonomic Research. 32:497-506
Purpose Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse event of cancer treatment that can affect sensory, motor, or autonomic nerves. Assessment of autonomic neuropathy is challenging, with limited available tools. Accordingly, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bde4e577243aa7f9cd00c3dd71b808
https://doi.org/10.1007/s10286-022-00895-w
https://doi.org/10.1007/s10286-022-00895-w
Autor:
Natalie Grima, Lyndal Henden, Liam G. Fearnley, Dominic B. Rowe, Susan D'Silva, Roger Pamphlett, Lorel Adams, Matthew C. Kiernan, Srestha Mazumder, Hannah C. Timmins, Margaret Zoing, Melanie Bahlo, Ian P. Blair, Kelly L. Williams
Publikováno v:
Neurobiology of Aging. 116:92-95
Sporadic amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a complex genetic architecture. The lengths of two short tandem repeats (STRs), at the NEK1 and STMN2 loci, were recently associated with ALS risk in cohorts of Eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffda3a459215eb676498444ba36d4185
https://doi.org/10.1016/j.neurobiolaging.2022.04.012
https://doi.org/10.1016/j.neurobiolaging.2022.04.012
Short tandem repeat expansions in sporadic amyotrophic lateral sclerosis and frontotemporal dementia
Autor:
Lyndal Henden, Liam G. Fearnley, Natalie Grima, Emily P. McCann, Carol Dobson-Stone, Lauren Fitzpatrick, Kathryn Friend, Lynne Hobson, Sandrine Chan Moi Fat, Dominic B. Rowe, Susan D’Silva, John B. Kwok, Glenda M. Halliday, Matthew C. Kiernan, Srestha Mazumder, Hannah C. Timmins, Margaret Zoing, Roger Pamphlett, Lorel Adams, Melanie Bahlo, Ian P. Blair, Kelly L. Williams
Publikováno v:
Science Advances. 9
Pathogenic short tandem repeat (STR) expansions cause over 20 neurodegenerative diseases. To determine the contribution of STRs in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), we used ExpansionHunter, REviewer, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7e922977e297828fc309ac4276362b
https://doi.org/10.1126/sciadv.ade2044
https://doi.org/10.1126/sciadv.ade2044
Autor:
Katherine Phan, Ying He, Surabhi Bhatia, Russell Pickford, Gordon McDonald, Srestha Mazumder, Hannah C Timmins, John R Hodges, Olivier Piguet, Nicolas Dzamko, Glenda M Halliday, Matthew C Kiernan, Woojin Scott Kim
Publikováno v:
Brain Communications. 5
Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and loss of various muscular functions. Dyslipidaemia is prevalent in amyotrophic lateral sclerosis with aberrant chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20190ae0f226372181f94b648ebb4ce2
https://doi.org/10.1093/braincomms/fcac340
https://doi.org/10.1093/braincomms/fcac340
Publikováno v:
Expert review of neurotherapeutics.
Amyotrophic Lateral Sclerosis (ALS) brings unique challenges to a clinical trial setting, due in part to relatively low disease prevalence coupled with a poor prognosis, in addition to the complexities linked to disease heterogeneity. As critical und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c81dad11a54045b9c6c586c9a30183
https://pubmed.ncbi.nlm.nih.gov/36543326
https://pubmed.ncbi.nlm.nih.gov/36543326
Autor:
Srestha Mazumder, Matthew C. Kiernan, Glenda M. Halliday, Hannah C. Timmins, Colin J. Mahoney
Publikováno v:
Neuropathology and applied neurobiology. 48(7)
Over the past decade, considerable efforts have been made to accelerate pathophysiological understanding of fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) with brain banks at the forefront. In addition to exploratory dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5575f89976209b33a963f1d67b2eff6
https://pubmed.ncbi.nlm.nih.gov/35921237
https://pubmed.ncbi.nlm.nih.gov/35921237
Autor:
Tiffany Li, Michael Friedlander, David Goldstein, Susanna B. Park, Lisa G. Horvath, Matthew C. Kiernan, David Mizrahi, Michelle Harrison, Hannah C. Timmins, Terry Trinh
Publikováno v:
Journal of Cancer Survivorship. 16:223-232
Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of neurotoxic cancer treatment, often impacting treatment tolerability and patient functioning. Factors predicting an individual’s vulnerability for developing CIPN remain ill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdfde2a1edad31e7cea355348568158a
https://doi.org/10.1007/s11764-021-01012-y
https://doi.org/10.1007/s11764-021-01012-y
Publikováno v:
ACS Sensors. 6:1261-1269
Platinum complexes remain frontline anticancer therapies, even after 50 years of usage in clinical applications. However, there is still a lack of methodology to robustly detect and quantify these complexes in biological fluids. We report here a fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553003929483ffa11f079faa139093b6
https://doi.org/10.1021/acssensors.0c02553
https://doi.org/10.1021/acssensors.0c02553
Autor:
Susanna B. Park, Matthew C. Kiernan, David Goldstein, Hannah C. Timmins, David Mizrahi, Tiffany Li
Publikováno v:
Journal of Cancer Survivorship. 17:222-236
Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common dose-limiting toxicity of cancer treatment causing functional impairment and impacting quality of life. Effective prevention and treatment of CIPN are lacking, and CIPN risk factors rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b811443b9a0391e1a51759d139288fae
https://doi.org/10.1007/s11764-021-00988-x
https://doi.org/10.1007/s11764-021-00988-x