Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannah B. Gordon"'
Autor:
Anna Sivachenko, Hannah B. Gordon, Suzanne S. Kimball, Erin J. Gavin, Joshua L. Bonkowsky, Anthea Letsou
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 4, Pp 377-387 (2016)
Debilitating neurodegenerative conditions with metabolic origins affect millions of individuals worldwide. Still, for most of these neurometabolic disorders there are neither cures nor disease-modifying therapies, and novel animal models are needed f
Externí odkaz:
https://doaj.org/article/99dbc38d70b94e33b7cd07d36077457f
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 6 (2018)
Adrenoleukodystrophy (ALD) is a fatal progressive neurodegenerative disorder affecting brain white matter. The most common form of ALD is X-linked (X-ALD) and results from mutation of the ABCD1-encoded very-long-chain fatty acid (VLCFA) transporter.
Externí odkaz:
https://doaj.org/article/cae2fc5f5276420fb7b466547750ce63
Autor:
Yolanda T. Chong, Vlad Rodic, Fiona L. Weathersby, Carl A. Brooks, Michael F. Cuccarese, Nathan H. Lazar, Ian K. Quigley, Christopher C. Gibson, Ronald W. Alfa, Berton A. Earnshaw, Kirk R. Thomas, Michael A. Statnick, Brandon L. Probst, Ben Fogelson, Nicholas D. Campbell, Jes Ford, Kathleen-Rose Skelly, Mason L. Victors, Seth W. Glazier, Peter F. McLean, James D. Jensen, Imran S. Haque, Anne E. Carpenter, Sharath S. Hegde, Chadwick T. Davis, Katie Heiser, Pamela Jacobson, Brandon M. Mendivil, Adeline S. Low, Joseph Carpenter, Elissa D. Pastuzyn, Hannah B. Gordon
Development of accurate disease models and discovery of immune-modulating drugs is challenged by the immune system’s highly interconnected and context-dependent nature. Here we apply deep-learning-driven analysis of cellular morphology to develop a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c21782616d4199bcf88ffc3650d4b4
https://doi.org/10.1101/2020.08.02.233064
https://doi.org/10.1101/2020.08.02.233064
Autor:
Christopher C. Gibson, Yolanda T. Chong, Peter F. McLean, Mason L. Victors, Adeline S. Low, Ben J. Miller, Hannah B. Gordon, Chadwick T. Davis, Katie Heiser, Imran S. Haque, Pamela Jacobson, Ronald W. Alfa, Berton A. Earnshaw, Ben Fogelson, Brett L. Hurst
To identify potential therapeutic stop-gaps for SARS-CoV-2, we evaluated a library of 1,670 approved and reference compounds in an unbiased, cellular image-based screen for their ability to suppress the broad impacts of the SARS-CoV-2 virus on phenom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261a386f110bc743b3822ae37d93cfb4
https://doi.org/10.1101/2020.04.21.054387
https://doi.org/10.1101/2020.04.21.054387
Publikováno v:
Dev Biol
Epithelial morphogenesis, a fundamental aspect of development, generates 3-dimensional tissue structures crucial for organ function. Underlying morphogenetic mechanisms are, in many cases, poorly understood, but mutations that perturb organ developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35491fa9ccd13055a282ce879f50a12
Autor:
Anthea Letsou, Hannah B. Gordon, Joshua L. Bonkowsky, Suzanne S. Kimball, Anna Sivachenko, Erin J. Gavin
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 4, Pp 377-387 (2016)
Disease Models & Mechanisms
Disease Models & Mechanisms
Debilitating neurodegenerative conditions with metabolic origins affect millions of individuals worldwide. Still, for most of these neurometabolic disorders there are neither cures nor disease-modifying therapies, and novel animal models are needed f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4323a3cd2dc2f6d77032b52669ac1718
http://dmm.biologists.org/content/9/4/377
http://dmm.biologists.org/content/9/4/377
Autor:
Keith R. Carney, Brooke Froelich Murray, Sarah Lusk, Emily O. Wirick, Hannah B. Gordon, Kristen M. Kwan
Publikováno v:
Development (Cambridge, England)
Establishment of precise three-dimensional tissue structure is vital for organ function. In the visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood process, disruptions of which can lead to coloboma, a birth defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed426404721a3e8b8ba14f01833ee79e
https://doi.org/10.1242/dev.165068
https://doi.org/10.1242/dev.165068
Publikováno v:
Seminars in Neurology. 34:312-320
Leukodystrophies are a group of genetically determined disorders that affect development or maintenance of central nervous system myelin. Leukodystrophies have a reported incidence of 1 in 7500 live births, but fewer than half of patients receive a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d698e7f17c043f9b275cccb680111b15
https://doi.org/10.1055/s-0034-1386769
https://doi.org/10.1055/s-0034-1386769
Publikováno v:
Infection and immunity. 77(5)
While in transit within and between hosts, uropathogenic Escherichia coli (UPEC) encounters multiple stresses, including substantial levels of nitric oxide and reactive nitrogen intermediates. Here we show that UPEC, the primary cause of urinary trac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11038d27eb8b20064a709bda6a24a8a9
https://pubmed.ncbi.nlm.nih.gov/19255192
https://pubmed.ncbi.nlm.nih.gov/19255192
Publikováno v:
Cellular microbiology. 10(12)
The FimH adhesin, localized at the distal tips of type 1 pili, binds mannose-containing glycoprotein receptors like alpha3beta1 integrins and stimulates bacterial entry into target host cells. Strains of uropathogenic Escherichia coli (UPEC), the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a39f3ba382ed7e5f5cbb706d5685b8
https://pubmed.ncbi.nlm.nih.gov/18754852
https://pubmed.ncbi.nlm.nih.gov/18754852