Výsledky vyhledávání - "Hannah A D King"

Akademický článek

Conjugation of an scFab domain to the oligomeric HIV envelope protein for use in immune targeting.

Autor: Hannah A D King, Christopher A Gonelli, Kirsteen M Tullett, Mireille H Lahoud, Damian F J Purcell, Heidi E Drummer, Pantelis Poumbourios, Rob J Center

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220986 (2019)

A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and

Externí odkaz: https://doaj.org/article/d564ce87a08a43f9a3a3f5e3be9de528

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Akademický článek

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Autor: Rajeshwer S. Sankhala, Kerri G. Lal, Jaime L. Jensen, Vincent Dussupt, Letzibeth Mendez-Rivera, Hongjun Bai, Lindsay Wieczorek, Sandra V. Mayer, Michelle Zemil, Danielle A. Wagner, Samantha M. Townsley, Agnes Hajduczki, William C. Chang, Wei-Hung Chen, Gina C. Donofrio, Ningbo Jian, Hannah A. D. King, Cynthia G. Lorang, Elizabeth J. Martinez, Phyllis A. Rees, Caroline E. Peterson, Fabian Schmidt, Tricia J. Hart, Debra K. Duso, Lawrence W. Kummer, Sean P. Casey, Jazmean K. Williams, Shruthi Kannan, Bonnie M. Slike, Lauren Smith, Isabella Swafford, Paul V. Thomas, Ursula Tran, Jeffrey R. Currier, Diane L. Bolton, Edgar Davidson, Benjamin J. Doranz, Theodora Hatziioannou, Paul D. Bieniasz, Dominic Paquin-Proulx, William W. Reiley, Morgane Rolland, Nancy J. Sullivan, Sandhya Vasan, Natalie D. Collins, Kayvon Modjarrad, Gregory D. Gromowski, Victoria R. Polonis, Nelson L. Michael, Shelly J. Krebs, M. Gordon Joyce

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the an

Externí odkaz: https://doaj.org/article/61dc74f1c5d84f64ac1178c032cab9f4

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Akademický článek

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionAntibody therapeutic strategies have served an important role during the COVID-19 pandemic, even as their effectiveness has waned with the emergence of escape variants. Here we sought to determine the concentration of convalescent immunog

Externí odkaz: https://doaj.org/article/c52c6e6701da487ba8ca0ca3fe209401

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A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

Publikováno v: Vaccines; Volume 10; Issue 5; Pages: 717

The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies are still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35da249d344b9aa1a44df4332bc7ef1
https://pubmed.ncbi.nlm.nih.gov/35632473

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A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates

Autor: M. Gordon Joyce, Hannah A. D. King, Ines Elakhal-Naouar, Aslaa Ahmed, Kristina K. Peachman, Camila Macedo Cincotta, Caroline Subra, Rita E. Chen, Paul V. Thomas, Wei-Hung Chen, Rajeshwer S. Sankhala, Agnes Hajduczki, Elizabeth J. Martinez, Caroline E. Peterson, William C. Chang, Misook Choe, Clayton Smith, Parker J. Lee, Jarrett A. Headley, Mekdi G. Taddese, Hanne A. Elyard, Anthony Cook, Alexander Anderson, Kathryn McGuckin Wuertz, Ming Dong, Isabella Swafford, James Brett Case, Jeffrey R. Currier, Kerri G. Lal, Sebastian Molnar, Manoj S. Nair, Vincent Dussupt, Sharon P. Daye, Xiankun Zeng, Erica K. Barkei, Hilary M. Staples, Kendra Alfson, Ricardo Carrion, Shelly J. Krebs, Dominic Paquin-Proulx, Nicos Karasavva, Victoria R. Polonis, Linda L. Jagodzinski, Mihret F. Amare, Sandhya Vasan, Paul T. Scott, Yaoxing Huang, David D. Ho, Natalia de Val, Michael S. Diamond, Mark G. Lewis, Mangala Rao, Gary R. Matyas, Gregory D. Gromowski, Sheila A. Peel, Nelson L. Michael, Diane L. Bolton, Kayvon Modjarrad

Publikováno v: Science translational medicine. 14(632)

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019. We developed and evaluated an adjuvanted SA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77e2f4f28a3e889ca79e5da0678f1ec
https://pubmed.ncbi.nlm.nih.gov/34914540

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Blocking α 4 β 7 integrin binding to SIV does not improve virologic control

Autor: Brandon F. Keele, Nami Iwamoto, Peter D. Kwong, Jeffrey D. Lifson, Mario Roederer, Susie Min, Jason Gorman, Kaimei Song, Rosemarie D. Mason, Kathryn E. Foulds, Hugh C. Welles, Hannah A. D. King, Aaron J. Belli, James Arthos, Claudia Cicala, Keith A. Reimann

Publikováno v: Science

An antibody is not the antidote An HIV therapeutic that would give long-term remission without sustained antiretroviral therapy (ART) is a long-term goal. Byrareddy et al. [ Science 354 , 197 (2016)] reported that treating simian immunodeficiency vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999914ec6a6d7f7460e4c89b16cbf49a
https://doi.org/10.1126/science.aaw7765

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Immunogenicity of HIV-1-Based Virus-Like Particles with Increased Incorporation and Stability of Membrane-Bound Env

Autor: Hannah A D King, Damian F. J. Purcell, Christopher A Gonelli, Secondo Sonza, Charlene Mackenzie

Publikováno v: Vaccines
Vaccines, Vol 9, Iss 239, p 239 (2021)
Volume 9
Issue 3

An optimal prophylactic vaccine to prevent human immunodeficiency virus (HIV-1) transmission should elicit protective antibody responses against the HIV-1 envelope glycoprotein (Env). Replication-incompetent HIV-1 virus-like particles (VLPs) offer th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa59d74ed74127e7826bf4d5db3ade69
http://europepmc.org/articles/PMC8002006

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