Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hannah A, Pliner"'
Autor:
Kenneth L, Chiou, Alex R, DeCasien, Katherina P, Rees, Camille, Testard, Cailyn H, Spurrell, Aishwarya A, Gogate, Hannah A, Pliner, Sébastien, Tremblay, Arianne, Mercer, Connor J, Whalen, Josué E, Negrón-Del Valle, Mareike C, Janiak, Samuel E, Bauman Surratt, Olga, González, Nicole R, Compo, Michala K, Stock, Angelina V, Ruiz-Lambides, Melween I, Martínez, Melissa A, Wilson, Amanda D, Melin, Susan C, Antón, Christopher S, Walker, Jérôme, Sallet, Jason M, Newbern, Lea M, Starita, Jay, Shendure, James P, Higham, Lauren J N, Brent, Michael J, Montague, Michael L, Platt, Noah, Snyder-Mackler
Publikováno v:
Nat Neurosci
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N
Autor:
Lena Christiansen, Lauren M. Saunders, Vijay Ramani, Dana Jackson, Hannah A. Pliner, Jay Shendure, Cole Trapnell, Frank J. Steemers, Jonathan S. Packer, José L. McFaline-Figueroa, Fan Zhang, Riza M. Daza, Sanjay Srivatsan, Junyue Cao
Publikováno v:
Science
Single-cell chemical transcriptomics Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Srivatsan et al. now add another layer of information and complexity
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136929 (2015)
Protein degradation via the multistep ubiquitin/26S proteasome pathway is a rapid way to alter the protein profile and drive cell processes and developmental changes. Many key regulators of embryonic development are targeted for degradation by E3 ubi
Externí odkaz:
https://doaj.org/article/b2a72940070c4441a9427c4d46fedbf9
Autor:
Diana R. O’Day, Michael Zager, Fan Zhang, Riza M. Daza, Dan Doherty, Ian A. Glass, Paul D. Kingsley, Cole Trapnell, Kimberly A. Aldinger, Malte Spielmann, Hannah A. Pliner, Frank J. Steemers, Ronnie Blecher-Gonen, Mei Deng, James Palis, Jay Shendure, Junyue Cao
Publikováno v:
Science
The genomics of human development Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d33f0c489e84beeb3282a55a4b46b1
https://hdl.handle.net/21.11116/0000-0007-AD31-F21.11116/0000-0007-AD33-D
https://hdl.handle.net/21.11116/0000-0007-AD31-F21.11116/0000-0007-AD33-D
Autor:
Raquel Marco-Ferreres, Darren A. Cusanovich, David A. Garfield, Jay Shendure, Cole Trapnell, Riza M. Daza, Frank J. Steemers, James P. Reddington, Eileen E. M. Furlong, Delasa Aghamirzaie, Lena Christiansen, Xiaojie Qiu, Hannah A. Pliner
Publikováno v:
Nature
An improved assay for chromatin accessibility at single-cell resolution in Drosophila melanogaster embryos enables identification of developmental-stage- and cell-lineage-specific patterns of chromatin-level transcriptional regulation. Active gene re
Publikováno v:
Nature methods
Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex trajectories with multiple branches remains a challenging computational problem. We present Monocle 2, an algorithm that u
Autor:
Pentti J. Tienari, Al-Saif H, Ruth Chia, Jinhui Ding, Janel O. Johnson, Claire Troakes, Maura Brunetti, Emily Bonkowski, Mark R. Cookson, Gabriele Mora, Pamela J. Shaw, Adriano Chiò, Simon Topp, Mike A. Nalls, Ammar Al-Chalabi, Bryan J. Traynor, Christopher Shaw, Carol Dobson-Stone, Natalie Landeck, Leigh F, Nada Alahmady, Nathan A. Smith, Olga Pletnikova, David J. Stone, Ian P. Blair, Robert H. Brown, Chang Ij, Thomas O. Crawford, Silani, Marc Gotkine, Alfredo Iacoangeli, Juan C. Troncoso, Karen E. Morrison, Ian A. Glass, Sarah A. Ahmed, Gibbs, Alan E. Renton, Marya S. Sabir, Aleksey Shatunov, Sonja W. Scholz, Li R, Bradley N. Smith, John Landers, Ravindran Kumaran, John B.J. Kwok, Ashley R. Jones, Andrea Calvo, Danny E. Miller, C. Gellera, Faraz Faghri, Hannah A. Pliner, England Bk, Nicola Ticozzi, Yevgeniya Abramzon, Al Khleifat A, Seth J. Perlman, Clifton L. Dalgard
SPTLC1 encodes a critical subunit of serine palmitoyltransferase, the enzyme catalyzing the first and rate-limiting step in de novo sphingolipid biosynthesis, and mutations in this gene are known to cause hereditary sensory autonomic neuropathy, type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986bb8802774f083fd5d45a54d71ec5b
https://doi.org/10.1101/770339
https://doi.org/10.1101/770339
Autor:
Cole Trapnell, John R. Sinnamon, Sarah A. Vitak, Michael W. Linhoff, Frank J. Steemers, Hannah A. Pliner, Gail Mandel, Andrew Adey, Kristof A. Torkenczy
Here we present a comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution. Substantial advances of this work include the optimization of single-cell combinatorial indexing assay for transposase acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a0f44e8d9c4016d8cf364a533011af
https://doi.org/10.1101/407668
https://doi.org/10.1101/407668
Autor:
Andrew Adey, Michael W. Linhoff, Frank J. Steemers, Cole Trapnell, Hannah A. Pliner, Ryan M. Mulqueen, John R. Sinnamon, Gail Mandel, Sarah A. Vitak, Kristof A. Torkenczy
Publikováno v:
Genome research. 29(5)
Here we present a comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution. Substantial advances of this work include the optimization of a single-cell combinatorial indexing assay for transposase acc
Autor:
Jay Shendure, Lena Christiansen, José L. McFaline-Figueroa, Frank J. Steemers, Cole Trapnell, Andrew Adey, Darren A. Cusanovich, Vijay Ramani, Riza M. Daza, Hannah A. Pliner, Jonathan S. Packer, Junyue Cao, Andrew J. Hill, Delasa Aghamirzaie
Publikováno v:
Science (New York, N.Y.). 361(6409)
Single-cell chromatin and RNA analysis Single-cell analyses have begun to provide insight into the differences among and within the individual cells that make up a tissue or organism. However, technological barriers owing to the small amount of mater