Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hannah, Wurzer"'
Publikováno v:
PLoS Biology, Vol 19, Iss 8 (2021)
How cytotoxic lymphocytes are protected against their own weapons during close combat with diseased target cells is an important and long-standing question in immunology. A study in this issue provides new insights into the mechanisms by which natura
Externí odkaz:
https://doaj.org/article/cb7546c9a52e438a9d79511fe98c706a
Autor:
Hannah Wurzer, Liza Filali, Céline Hoffmann, Max Krecke, Andrea Michela Biolato, Jérôme Mastio, Sigrid De Wilde, Jean Hugues François, Anne Largeot, Guy Berchem, Jérôme Paggetti, Etienne Moussay, Clément Thomas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term. For effective lys
Externí odkaz:
https://doaj.org/article/6022f7d32a004eda80782d5d6124ada7
Autor:
Jérôme Mastio, Mezida B. Saeed, Hannah Wurzer, Max Krecke, Lisa S. Westerberg, Clément Thomas
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system. As a result, PID patients are mo
Externí odkaz:
https://doaj.org/article/99592bf8e5324e7f844b48103c560886
Autor:
Céline Hoffmann, Xianqing Mao, Joshua Brown-Clay, Flora Moreau, Antoun Al Absi, Hannah Wurzer, Barbara Sousa, Fernando Schmitt, Guy Berchem, Bassam Janji, Clément Thomas
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Hypoxia is a common feature of solid tumours that promotes invasion and metastatic dissemination. Invadopodia are actin-rich membrane protrusions that direct extracellular matrix proteolysis and facilitate tumour cell invasion. Here, we show
Externí odkaz:
https://doaj.org/article/9aa369442f8843179906f34893c25651
Autor:
Clément Thomas, Bassam Janji, Guy Berchem, Salem Chouaib, Jean-Paul Thiery, Monika Dieterle, Carla Pou Casellas, Rémi Petrolli, Joshua Brown-Clay, Xianqing Mao, Flora Moreau, Celine Hoffmann, Coralie Guerin, Hannah Wurzer, Antoun Al Absi
Time lapse imaging movie showing typical actin cytoskeleton configurations and dynamics in MCF-7 cells upon NK cell attack. Individual Z stacks were taken every minute over a period of 77 minutes. Time lapse movies were assembled from the Z stacks in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af14936bf2a012f94ccb69d0a5209b7
https://doi.org/10.1158/0008-5472.22419207
https://doi.org/10.1158/0008-5472.22419207
Autor:
Clément Thomas, Bassam Janji, Guy Berchem, Salem Chouaib, Jean-Paul Thiery, Monika Dieterle, Carla Pou Casellas, Rémi Petrolli, Joshua Brown-Clay, Xianqing Mao, Flora Moreau, Celine Hoffmann, Coralie Guerin, Hannah Wurzer, Antoun Al Absi
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894299a75f7b6b6237c1ec33090038e3
https://doi.org/10.1158/0008-5472.22419222.v1
https://doi.org/10.1158/0008-5472.22419222.v1
Autor:
Clément Thomas, Bassam Janji, Guy Berchem, Salem Chouaib, Jean-Paul Thiery, Monika Dieterle, Carla Pou Casellas, Rémi Petrolli, Joshua Brown-Clay, Xianqing Mao, Flora Moreau, Celine Hoffmann, Coralie Guerin, Hannah Wurzer, Antoun Al Absi
Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e5ff98625536d267b667e7b1da51f9
https://doi.org/10.1158/0008-5472.c.6510318.v1
https://doi.org/10.1158/0008-5472.c.6510318.v1
Autor:
Clément Thomas, Bassam Janji, Guy Berchem, Salem Chouaib, Jean-Paul Thiery, Monika Dieterle, Carla Pou Casellas, Rémi Petrolli, Joshua Brown-Clay, Xianqing Mao, Flora Moreau, Celine Hoffmann, Coralie Guerin, Hannah Wurzer, Antoun Al Absi
Supplementary Figures S1-S6 and their legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048eb6dc9d96e562f0a177f68b1d5a19
https://doi.org/10.1158/0008-5472.22419225
https://doi.org/10.1158/0008-5472.22419225
Autor:
Marton Keszei, Joanna S. Kritikou, Deborah Sandfort, Minghui He, Mariana M.S. Oliveira, Hannah Wurzer, Raoul V. Kuiper, Lisa S. Westerberg
Publikováno v:
OncoImmunology, Vol 7, Iss 9 (2018)
The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton in hematopoietic cells and mutated in two severe immunodeficiency diseases with high incidence of cancer. Wiskott-Aldrich syndrome (WAS) is caused by loss-of-fun
Externí odkaz:
https://doaj.org/article/d7e5f88402d54a3781ad40f2e4251cb0
Publikováno v:
Cells, Vol 8, Iss 5, p 463 (2019)
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Externí odkaz:
https://doaj.org/article/981bddc76e3a429eb85dfe4c78b23e9c