Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hannah, Rostalski"'
Autor:
Dylan Scott Lykke Harwood, Vilde Pedersen, Nicolai Schou Bager, Ane Yde Schmidt, Tobias Overlund Stannius, Aušrinė Areškevičiūtė, Knud Josefsen, Dorte Schou Nørøxe, David Scheie, Hannah Rostalski, Maya Jeje Schuang Lü, Alessio Locallo, Ulrik Lassen, Frederik Otzen Bagger, Joachim Weischenfeldt, Dieter Henrik Heiland, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Bjarne Winther Kristensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy. Malignant cells escape surgical resection by migrating into the surr
Externí odkaz:
https://doaj.org/article/c9a8d9f57fc34c07b292a1cad2634555
Autor:
Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M. Mäkinen, Petri Mäkinen, Saša Končarević, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen, Henna Martiskainen, Susanna Kemppainen, Mikael Marttinen, Heli Jeskanen, Hannah Rostalski, Eija Rahunen, Miia Kivipelto, Tiia Ngandu, Teemu Natunen, Jean-Charles Lambert, Rudolph E. Tanzi, Doo Yeon Kim, Tuomas Rauramaa, Sanna-Kaisa Herukka, Hilkka Soininen, Markku Laakso, Ian Pike, Ville Leinonen, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106140- (2023)
The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer's disease (AD). Thereafter, different studies have discovered that the carriers of the APP A673T variant show r
Externí odkaz:
https://doaj.org/article/b8c8b78d1c5947a18f0f68c753c65493
Autor:
Nadine Huber, Dorit Hoffmann, Raisa Giniatullina, Hannah Rostalski, Stina Leskelä, Mari Takalo, Teemu Natunen, Eino Solje, Anne M. Remes, Rashid Giniatullin, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105584- (2022)
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD
Externí odkaz:
https://doaj.org/article/0d8dcea9ac014ce6b915a51bc64162b9
Autor:
Hannah Rostalski, Tomi Hietanen, Stina Leskelä, Andrea Behánová, Ali Abdollahzadeh, Rebekka Wittrahm, Petra Mäkinen, Nadine Huber, Dorit Hoffmann, Eino Solje, Anne M. Remes, Teemu Natunen, Mari Takalo, Jussi Tohka, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Hexanucleotide repeat expansion (HRE) in the chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause underpinning frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). It leads to the accumulatio
Externí odkaz:
https://doaj.org/article/7ee95a02d4244ed2974cb00b06245408
Autor:
Hannah Rostalski, Stina Leskelä, Nadine Huber, Kasper Katisko, Antti Cajanus, Eino Solje, Mikael Marttinen, Teemu Natunen, Anne M. Remes, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with a complex, but often overlapping, genetic and pathobiological background and thus they are considered to form a disease spectrum. Alt
Externí odkaz:
https://doaj.org/article/e1d3a20842544134bab22774b056de7e
Autor:
Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M Mäkinen, Petri Mäkinen, Saša Končarević, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen, Henna Martiskainen, Susanna Kemppainen, Mikael Marttinen, Heli Jeskanen, Hannah Rostalski, Eija Rahunen, Miia Kivipelto, Tiia Ngandu, Teemu Natunen, Jean-Charles Lambert, Rudolph E Tanzi, Doo Yeon Kim, Tuomas Rauramaa, Sanna-Kaisa Herukka, Hilkka Soininen, Markku Laakso, Ian Pike, Ville Leinonen, Annakaisa Haapasalo, Mikko Hiltunen
Background: The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer’s disease (AD). Thereafter, different studies have discovered that the carriers of the APP A673T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c75df709d7b9af64e809cddd2bb9d7
https://doi.org/10.21203/rs.3.rs-2275464/v1
https://doi.org/10.21203/rs.3.rs-2275464/v1
Autor:
Stina Leskelä, Nadine Huber, Hannah Rostalski, Teemu Natunen, Anne M. Remes, Mari Takalo, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Cells, Vol 8, Iss 10, p 1233 (2019)
Dysfunctional autophagy or ubiquitin-proteasome system (UPS) are suggested to underlie abnormal protein aggregation in neurodegenerative diseases. Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)-associated C9orf72 is implicated
Externí odkaz:
https://doaj.org/article/c9b4569e0b284adbac56383fede625f7
Autor:
Stina Leskelä, Sonja Korhonen, Paavo Honkakoski, Hannah Rostalski, Nadine Huber, Eino Solje, Anne M. Remes, Dorit Hoffmann, Annakaisa Haapasalo
Publikováno v:
Molecular Psychiatry
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers or effective disease-modifying therapies exist for the different clinical or ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4e8ebb6ad0db0272637b54fed68a86
Autor:
Nadine Huber, Dorit Hoffmann, Raisa Giniatullina, Hannah Rostalski, Stina Leskelä, Mari Takalo, Teemu Natunen, Eino Solje, Anne M. Remes, Rashid Giniatullin, Mikko Hiltunen, Annakaisa Haapasalo
Publikováno v:
Neurobiology of Disease, Vol 162, Iss, Pp 105584-(2022)
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b47b690456057de08421acfae8c9694c
https://pubmed.ncbi.nlm.nih.gov/34915153
https://pubmed.ncbi.nlm.nih.gov/34915153
Autor:
Nadine, Huber, Sonja, Korhonen, Dorit, Hoffmann, Stina, Leskelä, Hannah, Rostalski, Anne M, Remes, Paavo, Honkakoski, Eino, Solje, Annakaisa, Haapasalo
Publikováno v:
Molecular psychiatry. 27(3)
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers or effective disease-modifying therapies exist for the different clinical or ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1901ec57711023a75b776484a1d33edf
https://pubmed.ncbi.nlm.nih.gov/34799692
https://pubmed.ncbi.nlm.nih.gov/34799692