Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Autor: David A. Scheiblin, Alastair D. Lamb, Stephen J. Lockett, Uzi Gileadi, Ruth J. Muschel, Vincenzo Cerundolo, Su M. Phyu, Freddie C. Hamdy, Emma J. Murphy, Richard J. Bryant, Keaton Jones, Yiannis Philippou, Hanna T. Sjoberg, Said Alyacoubi, David A. Wink, Eileen Parkes, Ian G. Mills, Alex Gordon-Weeks, W. Gillies McKenna

Publikováno v: British Journal of Cancer

Background Radiotherapy enhances innate and adaptive anti-tumour immunity. It is unclear whether this effect may be harnessed by combining immunotherapy with radiotherapy fractions used to treat prostate cancer. We investigated tumour immune microenv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651c1ecc6ca7b13217ee344e16de86f9
http://europepmc.org/articles/PMC7525450

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Autor: Danny Allen, Stephen J. Lockett, Ruth J. Muschel, Tamar Yechezkel, Paul Kinchesh, Boris Vojnovic, Alastair D. Lamb, Hanna T. Sjoberg, Dina Preise, Richard J. Bryant, Jens Rittscher, Ka Ho Tam, Adrian L. Harris, Ian G. Mills, Yiannis Philippou, Anette L Magnussen, Iain D. C. Tullis, Emma A Murphy, Lilach Agemy, Freddie C. Hamdy, David A. Wink, Andrea Chatrian, Avigdor Scherz, Sean Smart, Joël Lefebvre, Stuart Gilchrist, Esther Bridges, David A. Scheiblin

Publikováno v: Sjoberg, H T, Philippou, Y, Magnussen, A L, Tullis, I D C, Bridges, E, Chatrian, A, Lefebvre, J, Tam, K H, Murphy, E A, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S C, Kinchesh, P, Gilchrist, S, Allen, D P, Scheiblin, D A, Lockett, S J, Wink, D A, Lamb, A D, Mills, I G, Harris, A, Muschel, R J, Vojnovic, B, Scherz, A, Hamdy, F C & Bryant, R J 2021, ' Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer ', British Journal of Cancer, vol. 125, pp. 534-546 . https://doi.org/10.1038/s41416-021-01450-6
British Journal of Cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e332f7007516e12e8126b136968964
https://pure.qub.ac.uk/en/publications/tumour-irradiation-combined-with-vasculartargeted-photodynamic-therapy-enhances-antitumour-effects-in-preclinical-prostate-cancer(a26d16da-6c3f-41e3-84f7-b20bf56280b2).html

Eosinophil-Mediated Immune Control of Adult Filarial Nematode Infection Can Proceed in the Absence of IL-4 Receptor Signaling

Autor: Nicolas Pionnier, Julio Furlong-Silva, Hanna T. Sjoberg, Alice Halliday, Amy E Marriott, John Archer, Andrew Steven, Joseph D. Turner, Mark J. Taylor

Publikováno v: JOURNAL OF IMMUNOLOGY
The Journal of Immunology Author Choice
Pionnier, N, Sjoberg, H, Furlong-Silva, J, Marriott, A, Halliday, A, Archer, J, Steven, A, Taylor, M J & Turner, J D 2020, ' Eosinophil-Mediated Immune Control of Adult Filarial Nematode Infection Can Proceed in the Absence of IL-4 Receptor Signaling ', Journal of Immunology, vol. 205, no. 3, pp. 731-740 . https://doi.org/10.4049/jimmunol.1901244

Key Points Immunity to chronic filarial worm infection is apparent in IL-4Rα–deficient mice. Delayed immunity in IL-4Rα−/− mice is due to suboptimal tissue eosinophilia. Eosinophil recruitment in the absence of IL-4R signaling requires CCR3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73816c9b4914be8fc9f3d126bcc34ff4

Harnessing the potential of multimodal radiotherapy in prostate cancer

Autor: Richard J. Bryant, Philip Camilleri, Hanna T. Sjoberg, Yiannis Philippou, Alastair D. Lamb

Radiotherapy in combination with androgen deprivation therapy (ADT) is a standard treatment option for men with localized and locally advanced prostate cancer. However, emerging clinical evidence suggests that radiotherapy can be incorporated into mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75064b621207fad3e2d20581e94e5c3
https://ora.ox.ac.uk/objects/uuid:57dffba4-30c6-4783-9b7d-7d8a31de2dee

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

Autor: Sabine Specht, Thomas W. von Geldern, Kelly L. Johnston, Franziska Lenz, Samuel Wanji, Joseph D. Turner, Nicolas Pionnier, Abdel Jelil Njouendou, Dominique Bloemker, Darren A. N. Cook, Robert A. Carr, Louise Ford, Stephen A. Ward, Mark J. Taylor, Kennan C. Marsh, Marianne Koschel, Hanna T. Sjoberg, Howard E. Morton, Dale J. Kempf, John Archer, Hayley E. Tyrer, Haelly M. Metuge, Fanny Fri Fombad, Ghaith Aljayyoussi, Valerinne C. Chunda, Patrick W. N. Chounna, Rachel H. Clare, Marc P. Hübner, Alexandra Ehrens, Achim Hoerauf, Andrew Steven, Emma A Murphy

Publikováno v: Science Translational Medicine. 11(483)

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bf4e4e87aab96ab422a6006d9f9f80
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