Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hanna Pincas"'
Autor:
Venugopalan D. Nair, Hanna Pincas, Mary Anne S. Amper, Yongchao Ge, Mital Vasoya, Archana Natarajan Raja, Martin J. Walsh, Stuart C. Sealfon
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103007- (2024)
Summary: Although reduced representation bisulfite sequencing (RRBS) measures DNA methylation (DNAme) across CpG-rich genomic regions with high sensitivity, the assay can be time-consuming and prone to batch effects. Here, we present a high-throughpu
Externí odkaz:
https://doaj.org/article/590d1fb6a61b40cd954ed0779e8c2e75
Autor:
Weiguang Mao, Clare M Miller, Venugopalan D Nair, Yongchao Ge, Mary Anne S Amper, Antonio Cappuccio, Mary‐Catherine George, Carl W Goforth, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Rachel S G Sealfon, Alessandra Soares‐Schanoski, Sindhu Vangeti, Mital Vasoya, Dawn L Weir, Elena Zaslavsky, Biobank Team, Vanessa Barcessat, Kevin Tuballes, Diane Marie Del Valle, Kai Nie, Hui Xie, Grace Chung, Manishkumar Patel, Jocelyn Harris, Kimberly Argueta, Jacques Fehr, Barr Gruberg, Nicholas Zaki, Seunghee Kim‐Schulze, Sacha Gnjatic, Miriam Merad, Andrew G Letizia, Olga G Troyanskaya, Stuart C Sealfon, Maria Chikina
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 5, Pp 1-16 (2023)
Abstract DNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as infection. We characterized the
Externí odkaz:
https://doaj.org/article/4218baf29182454bb07788f37ce0f8e4
Autor:
Natalia Mendelev, Michel Zamojski, Mary Anne S. Amper, Wan Sze Cheng, Hanna Pincas, Venugopalan D. Nair, Elena Zaslavsky, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101446- (2022)
Summary: Concomitant profiling of transcriptome and chromatin accessibility in isolated nuclei can reveal gene regulatory control mechanisms in health and disease. We report a single nucleus multi-omics analysis protocol optimized for frozen archived
Externí odkaz:
https://doaj.org/article/a3a9214cfbe7450d9f5f76742d262703
Autor:
Frederique Ruf-Zamojski, Zidong Zhang, Michel Zamojski, Gregory R. Smith, Natalia Mendelev, Hanqing Liu, German Nudelman, Mika Moriwaki, Hanna Pincas, Rosa Gomez Castanon, Venugopalan D. Nair, Nitish Seenarine, Mary Anne S. Amper, Xiang Zhou, Luisina Ongaro, Chirine Toufaily, Gauthier Schang, Joseph R. Nery, Anna Bartlett, Andrew Aldridge, Nimisha Jain, Gwen V. Childs, Olga G. Troyanskaya, Joseph R. Ecker, Judith L. Turgeon, Corrine K. Welt, Daniel J. Bernard, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The pituitary gland plays important roles in the regulation of key physiological functions. Here the authors provide a multiomics atlas including transcriptome, chromatin accessibility, and methylation status of over 70,000 single nuclei (sn) from mo
Externí odkaz:
https://doaj.org/article/c782850ef40d4c03ac0d69ac797d06d6
Autor:
Zidong Zhang, Michel Zamojski, Gregory R. Smith, Thea L. Willis, Val Yianni, Natalia Mendelev, Hanna Pincas, Nitish Seenarine, Mary Anne S. Amper, Mital Vasoya, Wan Sze Cheng, Elena Zaslavsky, Venugopalan D. Nair, Judith L. Turgeon, Daniel J. Bernard, Olga G. Troyanskaya, Cynthia L. Andoniadou, Stuart C. Sealfon, Frederique Ruf-Zamojski
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110467- (2022)
Summary: Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource from pediatric, adult, and aged postmortem pituita
Externí odkaz:
https://doaj.org/article/9778f6fbae6c4b3ebc1fa18a2a9f30e3
Autor:
Venugopalan D. Nair, Mital Vasoya, Vishnu Nair, Gregory R. Smith, Hanna Pincas, Yongchao Ge, Collin M. Douglas, Karyn A. Esser, Stuart C. Sealfon
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101681- (2022)
ATAC-seq is a fast and sensitive method for the epigenomic profiling of open chromatin and for mapping of transcription factor binding sites [1]. Despite the development of the Omni-ATAC protocol for the profiling of chromatin accessibility in frozen
Externí odkaz:
https://doaj.org/article/230c6c9f8a2a426ba34088c697d8b42b
Autor:
Venugopalan D. Nair, Yongchao Ge, Side Li, Hanna Pincas, Nimisha Jain, Nitish Seenarine, Mary Anne S. Amper, Bret H. Goodpaster, Martin J. Walsh, Paul M. Coen, Stuart C. Sealfon
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Exercise has multi-systemic benefits and attenuates the physiological impairments associated with aging. Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between tis
Externí odkaz:
https://doaj.org/article/e60e757d0a6745a28102a79b0d6f840a
Autor:
Boris M. Hartmann, Randy A. Albrecht, Elena Zaslavsky, German Nudelman, Hanna Pincas, Nada Marjanovic, Michael Schotsaert, Carles Martínez-Romero, Rafael Fenutria, Justin P. Ingram, Irene Ramos, Ana Fernandez-Sesma, Siddharth Balachandran, Adolfo García-Sastre, Stuart C. Sealfon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV supp
Externí odkaz:
https://doaj.org/article/98c3812ea23a4a069550f62b6a56b07d
Autor:
Frederique Ruf-Zamojski, Miguel Fribourg, Yongchao Ge, Venugopalan Nair, Hanna Pincas, Elena Zaslavsky, German Nudelman, Stephanie J. Tuminello, Hideo Watanabe, Judith L. Turgeon, Stuart C. Sealfon
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The LβT2 mouse pituitary cell line has many characteristics of a mature gonadotrope and is a widely used model system for studying the developmental processes and the response to gonadotropin-releasing hormone (GnRH). The global epigenetic landscape
Externí odkaz:
https://doaj.org/article/06959d9bfe0c4ef58f0b50a6da035dc6
Autor:
Rhonda A. Lizewski, Rachel S. G. Sealfon, Sang Woo Park, Gregory R. Smith, Chad K. Porter, Ana S. Gonzalez-Reiche, Yongchao Ge, Clare M. Miller, Carl W. Goforth, Hanna Pincas, Michael S. Termini, Irene Ramos, Venugopalan D. Nair, Stephen E. Lizewski, Hala Alshammary, Regina Z. Cer, Hua Wei Chen, Mary-Catherine George, Catherine E. Arnold, Lindsay A. Glang, Kyle A. Long, Francisco Malagon, Jan J. Marayag, Edgar Nunez, Gregory K. Rice, Ernesto Santa Ana, Megan A. Schilling, Darci R. Smith, Victor A. Sugiharto, Peifang Sun, Adriana van de Guchte, Zenab Khan, Jayeeta Dutta, Sindhu Vangeti, Logan J. Voegtly, Dawn L. Weir, C. Jessica E. Metcalf, Olga G. Troyanskaya, Kimberly A. Bishop-Lilly, Bryan T. Grenfell, Harm van Bakel, Andrew G. Letizia, Stuart C. Sealfon
Publikováno v:
Epidemiology. 33:797-807
Marine recruits training at Parris Island experienced an unexpectedly high rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, despite preventive measures including a supervised, 2-week, pre-entry quarantine. We characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a55105dccfe8711750749d91362db7
https://doi.org/10.1097/ede.0000000000001523
https://doi.org/10.1097/ede.0000000000001523