Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Hanna P. Lesch"'
2
Akademický článek
Functional roles of the membrane-associated AAV protein MAAP
Autor: Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory pr
Externí odkaz: https://doaj.org/article/cfb778447b9c4cc69e2061b9fd481166
Zobrazit plný text záznamu
3
Akademický článek
Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy
Autor: Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding. We co
Externí odkaz: https://doaj.org/article/bac6cbe4bcff4b7981f043f3a2f22c28
Zobrazit plný text záznamu
4
Akademický článek
Development of Large-Scale Downstream Processing for Lentiviral Vectors
Autor: Anniina J. Valkama, Igor Oruetxebarria, Eevi M. Lipponen, Hanna M. Leinonen, Piia Käyhty, Heidi Hynynen, Vesa Turkki, Joonas Malinen, Tuukka Miinalainen, Tommi Heikura, Nigel R. Parker, Seppo Ylä-Herttuala, Hanna P. Lesch
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 717-730 (2020)
The interest in lentiviral vectors (LVs) has increased prominently for gene therapy applications, but few have reached the later stages of clinical trials. The main challenge has remained in scaling up the manufacturing process for the fragile vector
Externí odkaz: https://doaj.org/article/7677766b879b48a5baadae07e874d057
Zobrazit plný text záznamu
5
Akademický článek
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells
Autor: Hanna M. Leinonen, Eevi M. Lipponen, Anniina J. Valkama, Heidi Hynynen, Igor Oruetxebarria, Vesa Turkki, Venla Olsson, Jere Kurkipuro, Haritha Samaranayake, Ann-Marie Määttä, Nigel R. Parker, Seppo Ylä-Herttuala, Hanna P. Lesch
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 63-71 (2019)
The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 1
Externí odkaz: https://doaj.org/article/58e30f80fca14c09842389d436188547
Zobrazit plný text záznamu
6
Akademický článek
Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations
Autor: Vesa Turkki, Elisa Alppila, Seppo Ylä-Herttuala, Hanna P. Lesch
Publikováno v: Viruses, Vol 13, Iss 5, p 939 (2021)
Virus particle concentration is a critical piece of information for virology, viral vaccines and gene therapy research. We tested a novel nanoparticle counting device, “Videodrop”, for its efficacy in titering and characterization of virus partic
Externí odkaz: https://doaj.org/article/7c4a4fd489b848d5a4e735c648cfcc78
Zobrazit plný text záznamu
10
Akademický článek
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages
Autor: Dawn Z Eichenfield, Ty Dale Troutman, Verena M Link, Michael T Lam, Han Cho, David Gosselin, Nathanael J Spann, Hanna P Lesch, Jenhan Tao, Jun Muto, Richard L Gallo, Ronald M Evans, Christopher K Glass
Publikováno v: eLife, Vol 5 (2016)
Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease. Here, we identify roles of Rev-erb nucle
Externí odkaz: https://doaj.org/article/9179063de878401aa231e8f29651e197
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje