Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Hanna N. Wetzel"'
1
Akademický článek
Student perceptions of scientific writing in pharmacology: Student generation of collaborative rubrics to score a social pharmacology writing project
Autor: Terri Enslein, Edward Kosack, Hanna N. Wetzel
Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract Scholarly writing is an important skill in all fields of study. Despite a strong focus on writing in many courses, faculty and students have disparate expectations related to scholarly writing. Herein, a classroom exercise is presented in wh
Externí odkaz: https://doaj.org/article/1dd498e7c9df440b8d5151404c6d46cc
Zobrazit plný text záznamu
2
Akademický článek
Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats
Autor: Hanna N. Wetzel, Vladimir L. Tsibulsky, Andrew B. Norman
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract According to pharmacological theory, the magnitude of an agonist-induced response is related to the number of receptors occupied. If there is a receptor reserve, when the number of receptors is altered the fractional occupancy required to ma
Externí odkaz: https://doaj.org/article/6588c02fe44b498cada5dc7949b74f17
Zobrazit plný text záznamu
3
Akademický článek
Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice
Autor: Mackenzie E. Turner, Hanna N. Wetzel, Dakota B. Zinani, Christopher A. Crutchfield, Andrew B. Norman
Publikováno v: Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice. D
Externí odkaz: https://doaj.org/article/dee88af421da49db8c47c107362dd31d
Zobrazit plný text záznamu
5
The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats
Autor: Dakota B. Zinani, Hanna N. Wetzel, Andrew B. Norman
Publikováno v: Brain Research. 1774:147707
Rats that reliably self-administered cocaine also reliably self-administered the cocaine analog RTI-55 and bupropion. The inter-injection intervals of these dopamine transporter (DAT) inhibitors were regular at a given unit dose and increased as a fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb01af2e85f48060c28b34654e15f1c5
https://doi.org/10.1016/j.brainres.2021.147707
Zobrazit plný text záznamu
6
A novel Python program for implementation of quality control in the ELISA
Autor: Cinder F. Cohen, Andrew B. Norman, Hanna N. Wetzel, Rose P. Webster
Publikováno v: J Immunol Methods
The use of semi-quantitative assays such as the enzyme-linked immunosorbent assay (ELISA) requires stringent quality control of the data. However, such quality control is often lacking in academic settings due to unavailability of software and knowle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf8b3e80b20bf9f8478decb40327af9
https://doi.org/10.1016/j.jim.2017.05.012
Zobrazit plný text záznamu
7
A mathematical model of a recombinant humanized anti-cocaine monoclonal antibody's effects on cocaine pharmacokinetics in mice
Autor: Andrew B. Norman, Hanna N. Wetzel, Tongli Zhang
Publikováno v: Life Sciences. 184:81-86
A recombinant humanized anti-cocaine monoclonal antibody (mAb), h2E2, is at an advanced stage of pre-clinical development as an immunotherapy for cocaine abuse. It is hypothesized that h2E2 binds to and sequesters cocaine in the blood.A three-compart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b6cd3eddc063109ad83e30d2b46d7b
https://doi.org/10.1016/j.lfs.2017.07.006
Zobrazit plný text záznamu
8
A novel differential scanning fluorimetry analysis of a humanized anti-cocaine mAb and its ligand binding characteristics
Autor: Andrew B. Norman, Terence L. Kirley, Hanna N. Wetzel
Publikováno v: Journal of immunological methods. 476
An anti-cocaine monoclonal antibody (mAb) designated h2E2 will soon enter clinical trials for the treatment of cocaine abuse disorders. Importantly, this antibody selectively binds cocaine and its active metabolite, cocaethylene, with high affinity,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c517adec6f21316400afcde41a5b8
https://pubmed.ncbi.nlm.nih.gov/31634480
Zobrazit plný text záznamu
9
A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats
Autor: Hassane Amlal, Sihame Amlal, Jordan A. Marckel, Hanna N. Wetzel, Andrew B. Norman
A recombinant humanized anticocaine monoclonal antibody, h2E2, has shown potential in the preclinical phases for the treatment of cocaine abuse. The standard tests for cocaine usage are the detection of benzoylecgonine (BE) and cocaine in the urine.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034c670752c85b7ab1c9c1fd45f7b343
https://europepmc.org/articles/PMC6367686/
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje