Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hanna M. Wisniewska"'
Autor:
Michelle R. Garnsey, Donna G. Blackmond, Daniel W. Kung, Hanna M. Wisniewska, Taegyo Lee, Neal W. Sach, James I. Murray, Anne-Marie R. Dechert-Schmitt
Publikováno v:
ACS Catalysis. 9:4508-4515
A one-pot, four-component Pd-catalyzed coupling has been developed for the synthesis of unsymmetrical 1,2-diketones from aryl halides and alkyl zincs employing tert-butyl isocyanide as a CO source. The intermediate 1,2-diketones have been elaborated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6954172e247d79052355b0fe8700a7
https://doi.org/10.1021/acscatal.9b00581
https://doi.org/10.1021/acscatal.9b00581
Autor:
Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy
Publikováno v:
Journal of medicinal chemistry. 63(22)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c107a413095d612ee94dff2632747e3a
https://pubmed.ncbi.nlm.nih.gov/32910646
https://pubmed.ncbi.nlm.nih.gov/32910646
Autor:
Ariana Hirsh, Robert Dullea, Meihua Tu, Spiros Liras, Joan Compte Barrón, Kris A. Borzilleri, Nannan Ma, Rima Mendonsa, Justin Bellenger, Romain Rouet, Lorena de Oñate, Xidong Feng, Jennifer A. Doudna, Nathanael G. Lintner, David M. Rubitski, Benjamin A. Thuma, Marc D. Roy, Alison H. Varghese, Kim F. McClure, Ross C. Wilson, Thomas J. McLellan, Hanna M. Wisniewska, James E. Finley, Boris A. Chrunyk, Vincent Mascitti, Kaihong Zhou, Kevin D. Hesp
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 21
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af967c5dc058dcd0e0a6cfe05eb8b81
https://doi.org/10.1021/jacs.8b01551
https://doi.org/10.1021/jacs.8b01551
Autor:
Donna G. Blackmond, Hanna M. Wisniewska, Anne-Marie R. Dechert-Schmitt, Olivia P. Schmidt, Michelle R. Garnsey
Experimental and kinetic modelling studies are presented to describe the development of temperature scanning reaction progress protocol for batch reactions. Coupled with graphical manipulations, this approach enables the expansion of in-situ kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061e6800fb00f58b564514313522c212
https://zenodo.org/record/3732622
https://zenodo.org/record/3732622
Autor:
Anne-Marie R. Dechert-Schmitt, Olivia P. Schmidt, Hanna M. Wisniewska, Donna G. Blackmond, Michelle R. Garnsey
Publikováno v:
ChemCatChem. 12:4695-4695
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d740fe40bcd30a38c6073353608e010
https://doi.org/10.1002/cctc.202000437
https://doi.org/10.1002/cctc.202000437
Publikováno v:
Organic letters. 20(10)
A diastereoselective, Pd-catalyzed Suzuki–Miyaura coupling reaction of geminal bis(boryl)cyclopropanes has been developed. The reaction offers a highly modular approach to the synthesis of tertiary cyclopropylboronic esters. The resulting boronic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582dcfa68b9fc50cb30c861900e3531e
https://pubmed.ncbi.nlm.nih.gov/29707948
https://pubmed.ncbi.nlm.nih.gov/29707948
Autor:
Robert Dullea, Kris A. Borzilleri, Romain Rouet, Vincent Mascitti, Ross C. Wilson, Boris A. Chrunyk, Ariana Hirsh, Benjamin A. Thuma, Xidong Feng, Jennifer A. Doudna, Hanna M. Wisniewska, Spiros Liras, Thomas J. McLellan, Kaihong Zhou, Kim F. McClure, James E. Finley, Joan Compte Barrón, Kevin D. Hesp, Meihua Tu, David M. Rubitski, Lorena de Oñate, Alison H. Varghese, Rima Mendonsa, Nannan Ma, Justin Bellenger, Marc D. Roy, Nathanael G. Lintner
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f270393f8db883382554c04a0d34fe48
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.2
Publikováno v:
Journal of the American Chemical Society. 135:9083-9090
The first Negishi nickel-catalyzed stereospecific cross-coupling reaction of secondary benzylic esters is reported. A series of traceless directing groups are evaluated for ability to promote cross-coupling with dimethylzinc. Esters with a chelating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a895c25c89edd449833134b86730d94
https://doi.org/10.1021/ja4034999
https://doi.org/10.1021/ja4034999
Publikováno v:
ChemInform. 45
Enantioselective propargylation and allenylation reactions pose an interesting challenge because they require control of regioselectivity as well as enantioselectivity. This review presents recent advances in enantioselective propargylation and allen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a295ed686f84e52c81dd85d7ab588db
https://doi.org/10.1002/chin.201409264
https://doi.org/10.1002/chin.201409264
Publikováno v:
The Journal of organic chemistry. 78(23)
Enantioselective propargylation and allenylation reactions pose an interesting challenge because they require control of regioselectivity as well as enantioselectivity. This review presents recent advances in enantioselective propargylation and allen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318f143bfad8a0e23a69f21c763b5b94
https://pubmed.ncbi.nlm.nih.gov/24266761
https://pubmed.ncbi.nlm.nih.gov/24266761