Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hanna M. Heikkilä"'
Autor:
Krista Nuotio, Suvi M. Koskinen, Laura Mäkitie, Jarno Tuimala, Petra Ijäs, Hanna M. Heikkilä, Jani Saksi, Pirkka Vikatmaa, Pia Sorto, Sonja Kasari, Ilari Paakkari, Heli Silvennoinen, Leena Valanne, Mikko I. Mäyränpää, Lauri Soinne, Petri T. Kovanen, Perttu J. Lindsberg
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Long-term treatment with the vitamin K antagonist warfarin is widely used for the prevention of venous thrombosis and thromboembolism. However, vitamin K antagonists may promote arterial calcification, a phenomenon that has been previousl
Externí odkaz:
https://doaj.org/article/5c6c283a6ee54c589b5473690426c2e2
Autor:
Heli Silvennoinen, Mikko I. Mäyränpää, Lauri Soinne, Leena Valanne, Petra Ijäs, Pirkka Vikatmaa, Suvi M. Koskinen, Henrietta Eriksson, Krista Nuotio, Hanna M. Heikkilä, Perttu J. Lindsberg, Petri T. Kovanen
Objective Across stroke subtypes, carotid artery stroke carries the highest risk of recurrence. Despite initiation of best medical therapy (BMT), some patients suffer recurrent neurological events before undergoing carotid endarterectomy (CEA). The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff5bb9721d9874c89a5b4dfe16b8e07
http://hdl.handle.net/10138/337417
http://hdl.handle.net/10138/337417
Autor:
Sonja Kasari, Suvi M. Koskinen, Pirkka Vikatmaa, Laura Mäkitie, Henrietta Eriksson, Mikko I. Mäyränpää, Krista Nuotio, Jani Saksi, Hanna M. Heikkilä, Petri T. Kovanen, Leena Valanne, Perttu J. Lindsberg, Petra Ijäs, Lauri Soinne, Heli Silvennoinen, Pia Sorto
Publikováno v:
Annals of Medicine. 50:501-510
Introduction: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention is the most cost-effective stroke therapy, antiplatelet and cholesterol-lowering drugs have a ceiling e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9137d8d0e6853a4344aa0eb3382397
https://doi.org/10.1080/07853890.2018.1494851
https://doi.org/10.1080/07853890.2018.1494851
Autor:
Matti Jauhiainen, Eija Jokitalo, Reijo Käkelä, Rabah Soliymani, Outi Kummu, Helena Vihinen, Su D. Nguyen, Perttu J. Lindsberg, Hanna M. Heikkilä, Satu Lehti, Marc Baumann, Petri T. Kovanen, Gregory A. Grabowski, Jani Saksi, Ilya Belevich, Sohvi Hörkkö, Katariina Öörni
Publikováno v:
The American journal of pathology. 188(2)
Lipid accumulation is a key characteristic of advancing atherosclerotic lesions. Herein, we analyzed the ultrastructure of the accumulated Lipids in endarterectomized human carotid atherosclerotic plaques using three-dimensional (3D) electron microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d11bf9e69c39ee1d41250fc85ffc6
https://pubmed.ncbi.nlm.nih.gov/29154769
https://pubmed.ncbi.nlm.nih.gov/29154769
Autor:
Soili Lätti, Markus J. Leskinen, Ken A. Lindstedt, Petri T. Kovanen, Jukka K. Hakala, Hanna M. Heikkilä
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:309-314
Objective— Activated mast cells (MCs) induce endothelial cell (EC) apoptosis in vitro and are present at sites of plaque erosions in vivo. To further elucidate the role of MCs in endothelial apoptosis and consequently in plaque erosion, we have stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db77a81fd7e2db488c52ae1ebfcf3551
https://doi.org/10.1161/atvbaha.107.151340
https://doi.org/10.1161/atvbaha.107.151340
Publikováno v:
Journal of vascular research. 49(1)
Objectives: Bradykinin type 2 receptor (BK-2R) knockout mice develop microvascular dysfunction and cardiac hypertrophy. In aged human cardiac microvascular endothelium, dysfunction develops before heart failure symptoms. Since endothelial aging is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5f37a963d17413f78431afaee6f0af
https://pubmed.ncbi.nlm.nih.gov/21986469
https://pubmed.ncbi.nlm.nih.gov/21986469
Publikováno v:
Coronary artery disease. 17(7)
Endothelial erosion has emerged as an important contributor to the pathogenesis of atherosclerosis and its complications, but the molecular mechanisms have remained unclear. As activated mast cells capable of secreting neutral proteases are present i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc9dc10f5103ab0c1e612334940546
https://pubmed.ncbi.nlm.nih.gov/17047445
https://pubmed.ncbi.nlm.nih.gov/17047445
Autor:
Jukka K. Hakala, Markus J. Leskinen, Ken A. Lindstedt, Hanna M. Heikkilä, Mika Laine, Mei Y. Speer, Petri T. Kovanen
Publikováno v:
Experimental cell research. 312(8)
Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eaecb95f84a2c855814a0fe7872316
https://pubmed.ncbi.nlm.nih.gov/16460729
https://pubmed.ncbi.nlm.nih.gov/16460729