Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hanna M. Doh"'
Autor:
Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai, Harvey R. Herschman
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Background Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have not been well characte
Externí odkaz:
https://doaj.org/article/440363d204aa4ccf82544f27f7fe42b8
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
This file contains supplemental figures: Supplemental Figure S1. HK2 ASOs selectively inhibit the proliferation of HK1-HK2+ MM cells. Supplemental Figure S2. The HK2-ASO1/DPI/PER combination causes synthetic lethality in HK1-HK2+ cells. Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e269c3863ca8a09ffd8d38c0cef8040b
https://doi.org/10.1158/0008-5472.22418646
https://doi.org/10.1158/0008-5472.22418646
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
This file contains supplemental materials and methods used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0bcbb63e2460070b4a06cf04376e3b
https://doi.org/10.1158/0008-5472.22418643
https://doi.org/10.1158/0008-5472.22418643
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
Metabolite measurement in OPM2 cells treated with HK2-ASO1, DPI, MET, PER, and their combinations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fba10c6f92b5e3c3c4d19929ad225f5
https://doi.org/10.1158/0008-5472.22418640
https://doi.org/10.1158/0008-5472.22418640
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many coexpress HK1 and HK2. In contrast to HK1+HK2+ cancers, HK1−HK2+ cancer subsets are sensitive to cytostasis indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c808dbea3036f46e88ee0faf6e3ec0a
https://doi.org/10.1158/0008-5472.c.6510183
https://doi.org/10.1158/0008-5472.c.6510183
Autor:
Thomas G. Graeber, Arthur Catapang, Shili Xu, Jason T. Lee, Harvey R. Herschman, Nicholas Bayley, Daniel Braas, Hanna M. Doh
Publikováno v:
J Nucl Med
Although absent in most adult tissues, hexokinase 2 (HK2) is expressed in most tumors and contributes to increased glucose consumption and to in vivo tumor (18)F-FDG PET signaling. Methods: Both HK2 knockdown and knockout approaches were used to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3188374e39585644ecba4b64dff2895a
https://doi.org/10.2967/jnumed.118.212365
https://doi.org/10.2967/jnumed.118.212365
Autor:
K. Ryan Trinh, Hanna M. Doh, Harvey R. Herschman, Jason T. Lee, Joshua P. Sasine, A. Robert MacLeod, Shili Xu, John M. Timmerman, Reiko E. Yamada, Daniel Braas, Tianyuan Zhou, Sarah Larson, Alex Vasuthasawat, Nicholas Bayley, Art Catapang, Sherie L. Morrison, Youngsoo Kim
Publikováno v:
Cancer research, vol 79, iss 10
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many coexpress HK1 and HK2. In contrast to HK1+HK2+ cancers, HK1−HK2+ cancer subsets are sensitive to cytostasis indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa17379001be53263a569dc0612d27c
https://escholarship.org/uc/item/9d7003c9
https://escholarship.org/uc/item/9d7003c9
Autor:
Shili, Xu, Tianyuan, Zhou, Hanna M, Doh, K Ryan, Trinh, Art, Catapang, Jason T, Lee, Daniel, Braas, Nicholas A, Bayley, Reiko E, Yamada, Alex, Vasuthasawat, Joshua P, Sasine, John M, Timmerman, Sarah M, Larson, Youngsoo, Kim, A Robert, MacLeod, Sherie L, Morrison, Harvey R, Herschman
Publikováno v:
Cancer Res
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many co-express HK1 and HK2. In contrast to HK1(+)HK2(+) cancers, HK1(−)HK2(+) cancer subsets are sensitive to cytost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecf1e4323701d38f9eff11fb3887814b
https://pubmed.ncbi.nlm.nih.gov/30885978
https://pubmed.ncbi.nlm.nih.gov/30885978