Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hanna M Eilken"'
Autor:
Shaan Khurshid, Christopher Reeder, Lia X. Harrington, Pulkit Singh, Gopal Sarma, Samuel F. Friedman, Paolo Di Achille, Nathaniel Diamant, Jonathan W. Cunningham, Ashby C. Turner, Emily S. Lau, Julian S. Haimovich, Mostafa A. Al-Alusi, Xin Wang, Marcus D. R. Klarqvist, Jeffrey M. Ashburner, Christian Diedrich, Mercedeh Ghadessi, Johanna Mielke, Hanna M. Eilken, Alice McElhinney, Andrea Derix, Steven J. Atlas, Patrick T. Ellinor, Anthony A. Philippakis, Christopher D. Anderson, Jennifer E. Ho, Puneet Batra, Steven A. Lubitz
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-14 (2022)
Abstract Electronic health record (EHR) datasets are statistically powerful but are subject to ascertainment bias and missingness. Using the Mass General Brigham multi-institutional EHR, we approximated a community-based cohort by sampling patients r
Externí odkaz:
https://doaj.org/article/cee0e785728d44acb66d820bf455a8f1
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Hanna M. Eilken, Rodrigo Diéguez-Hurtado, Inga Schmidt, Masanori Nakayama, Hyun-Woo Jeong, Hendrik Arf, Susanne Adams, Napoleone Ferrara, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced e
Externí odkaz:
https://doaj.org/article/0c3a3cf9ba3b4c24826d8cf136e3439f
Autor:
Nathaniel Diamant, Paolo Di Achille, Lu-Chen Weng, Emily S. Lau, Shaan Khurshid, Samuel Friedman, Christopher Reeder, Pulkit Singh, Xin Wang, Gopal Sarma, Mercedeh Ghadessi, Johanna Mielke, Eren Elci, Ivan Kryukov, Hanna M. Eilken, Andrea Derix, Patrick T. Ellinor, Christopher D. Anderson, Anthony A. Philippakis, Puneet Batra, Steven A. Lubitz, Jennifer E. Ho
Publikováno v:
Cardiovascular Digital Health Journal. 3:161-170
Postexercise heart rate recovery (HRR) is an important indicator of cardiac autonomic function and abnormal HRR is associated with adverse outcomes. We hypothesized that deep learning on resting electrocardiogram (ECG) tracings may identify individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1b74b120f0dad980dcca42c30b2c6b
https://doi.org/10.1016/j.cvdhj.2022.06.001
https://doi.org/10.1016/j.cvdhj.2022.06.001
Publikováno v:
BioTechniques, Vol 41, Iss 6, Pp 688-692 (2006)
Externí odkaz:
https://doaj.org/article/58adc342042646cab02438ac546f2c44
Autor:
Tilman Borggrefe, Marek Bartkuhn, M. Gabriele Bixel, Hanna M. Eilken, Melina Nieminen-Kelhä, Ralf H. Adams, Hendrik Arf, Rodrigo Diéguez-Hurtado, Susanne Adams, Peter Vajkoczy, Benedetto Daniele Giaimo, Katsuhiro Kato, Tobias Zimmermann, Francesca Ferrante
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications
Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6818fc6dd8ae1a8de98c29afebb5562
http://link.springer.com/article/10.1038/s41467-019-10643-w
http://link.springer.com/article/10.1038/s41467-019-10643-w
Autor:
Shaan Khurshid, Christopher Reeder, Lia X. Harrington, Pulkit Singh, Gopal Sarma, Samuel F. Friedman, Paolo Di Achille, Nathaniel Diamant, Jonathan W. Cunningham, Ashby C. Turner, Emily S. Lau, Julian S. Haimovich, Mostafa A. Al-Alusi, Xin Wang, Marcus D. R. Klarqvist, Jeffrey M. Ashburner, Christian Diedrich, Mercedeh Ghadessi, Johanna Mielke, Hanna M. Eilken, Alice McElhinney, Andrea Derix, Steven J. Atlas, Patrick T. Ellinor, Anthony A. Philippakis, Christopher D. Anderson, Jennifer E. Ho, Puneet Batra, Steven A. Lubitz
Publikováno v:
NPJ digital medicine. 5(1)
Electronic health record (EHR) datasets are statistically powerful but are subject to ascertainment bias and missingness. Using the Mass General Brigham multi-institutional EHR, we approximated a community-based cohort by sampling patients receiving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a195990a37e80d9154bdd0302f902099
https://pubmed.ncbi.nlm.nih.gov/35396454
https://pubmed.ncbi.nlm.nih.gov/35396454
Autor:
Khaled Nassar, Junsong Gong, Elia J. Duh, Hongkwan Cho, Hanna M. Eilken, Michael J. Lai, Jing Yang, Carsten Terjung, Qiaoyan Hui, Zhenhua Xu, Lingli Zhou, Marcus Karlstetter
Publikováno v:
Free Radic Biol Med
The Nrf2-Keap1 pathway regulates transcription of a wide array of antioxidant and cytoprotective genes and offers critical protection against oxidative stress. This pathway has demonstrated benefit for a variety of retinal conditions. Retinal ischemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced80113b913b4971fd8bc50308a43e2
https://pubmed.ncbi.nlm.nih.gov/31669760
https://pubmed.ncbi.nlm.nih.gov/31669760
Autor:
Douwe Oostinga, Ann L.B. Seynhaeve, Susanne Adams, Rien van Haperen, Ralf H. Adams, Hanna M. Eilken, Timo L.M. ten Hagen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, 8:9596. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, 8:9596. Nature Publishing Group
Endothelial cells and pericytes are integral cellular components of the vasculature with distinct interactive functionalities. To study dynamic interactions between these two cells we created two transgenic animal lines. A truncated eNOS (endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911ad12ae34d437a527440572c2016ea
http://europepmc.org/articles/PMC6018425
http://europepmc.org/articles/PMC6018425
Autor:
Hyun-Woo Jeong, Inga Schmidt, Ralf H. Adams, Rodrigo Diéguez-Hurtado, Napoleone Ferrara, Susanne Adams, Hanna M. Eilken, Hendrik Arf, Masanori Nakayama
Publikováno v:
Nature communications, vol 8, iss 1
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea990dd6e9839c0906203b56c6fa557b
https://escholarship.org/uc/item/6fn322r2
https://escholarship.org/uc/item/6fn322r2
