Výsledky vyhledávání - "Hanna Lewicki"

Expanded Potential for Recombinant Trisegmented Lymphocytic Choriomeningitis Viruses: Protein Production, Antibody Production, and In Vivo Assessment of Biological Function of Genes of Interest

Autor: Hanna Lewicki, Daniel L. Popkin, Juan Carlos de la Torre, John R. Teijaro, Michael B. A. Oldstone, Andrew M. Lee, Sébastien Emonet

Publikováno v: Journal of Virology. 85:7928-7932

The recombinant engineering of trisegmented lymphocytic choriomeningitis virus (LCMV) to express two genes of interest was recently reported. We used this technology to efficiently express green fluorescent protein (GFP) and the immunoregulatory gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0c7cc89842bb9bc35885c2f5fcb39
https://doi.org/10.1128/jvi.00486-11

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Mass Spectrometry Reveals Specific and Global Molecular Transformations during Viral Infection

Autor: Timothy D Veenstra, William R. Wikoff, Grace O'Maille, Sunia A. Trauger, David A Lucas, King C Chan, Thomas P Conrads, Anette Schneemann, Hanna Lewicki, Michael B. A. Oldstone, Hirotoshi Morita, Gary Siuzdak, Eden P. Go, Anders Nordström, Wilasinee Uritboonthai, Zhouxin Shen

Publikováno v: Journal of Proteome Research. 5:2405-2416

Mass spectrometry analysis was used to target three different aspects of the viral infection process: the expression kinetics of viral proteins, changes in the expression levels of cellular proteins, and the changes in cellular metabolites in respons

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https://doi.org/10.1021/pr060215t

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CD4 T cell control primary measles virus infection of the CNS: Regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective

Autor: Antoinette Tishon, Abegail A. Andaya, Lee Martin, Hanna Lewicki, Dorian B. McGavern, Michael B. A. Oldstone

Publikováno v: Virology. 347:234-245

Measles virus (MV), one of the most infectious of human pathogens, still infects over 30 million humans and causes over 500,000 deaths each year [Griffin, D., 2001. Measles virus. In: Fields, B., Knipe, D., Howley, P. (Eds.), Fields Virology. Lippinc

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https://doi.org/10.1016/j.virol.2006.01.050

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Evidence That the Hypermutated M Protein of a Subacute Sclerosing Panencephalitis Measles Virus Actively Contributes to the Chronic Progressive CNS Disease

Autor: T. Hanna Lewicki, Tatjana I. Cornu, Samuel Dales, John B. Patterson, Jeffrey M. Redwine, Martin A. Billeter, Michael B. A. Oldstone, Diane Thomas, Andreas Holz

Publikováno v: Virology. 291(2):215-225

Subacute sclerosing panencephalitis (SSPE) is a progressive degenerative disease of the brain uniformly leading to death. Although caused by measles virus (MV), the virus recovered from patients with SSPE differs from wild-type MV; biologically SSPE

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Structural and Functional Identification of Major Histocompatibility Complex Class I-restricted Self-peptides as Naturally Occurring Molecular Mimics of Viral Antigens

Autor: Odile Burlet-Schiltz, Bernard Monsarrat, Hanna Lewicki, Jean Edouard Gairin, Matthias von Herrath, Denis Hudrisier, Michael B. A. Oldstone, Joëlle Riond

Publikováno v: Journal of Biological Chemistry. 276:19396-19403

Structural similarity (molecular mimicry) between viral epitopes and self-peptides can lead to the induction of autoaggressive CD4(+) as well as CD8(+) T cell responses. Based on the flexibility of T cell receptor/antigen/major histocompatibility com

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https://doi.org/10.1074/jbc.m008864200

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Differences in Affinity of Binding of Lymphocytic Choriomeningitis Virus Strains to the Cellular Receptor α-Dystroglycan Correlate with Viral Tropism and Disease Kinetics

Autor: Kevin P. Campbell, Wei Cao, Antoinette Tishon, Michael B. A. Oldstone, Persephone Borrow, Hanna Lewicki, Stefan Kunz, Sara C. Smelt

Publikováno v: Journal of Virology. 75:448-457

α-Dystroglycan (α-DG) was recently identified as a receptor for lymphocytic choriomeningitis virus (LCMV) and several other arenaviruses, including Lassa fever virus (W. Cao, M. D. Henry, P. Borrow, H. Yamada, J. H. Elder, E. V. Ravkov, S. T. Nicho

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https://doi.org/10.1128/jvi.75.1.448-457.2001

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Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

Autor: Noemí Sevilla, Juan Carlos de la Torre, Andreas Holz, Stefan Kunz, Hiroki Yamada, Kevin P. Campbell, Michael B. A. Oldstone, Dirk Homann, Hanna Lewicki

Publikováno v: The Journal of Experimental Medicine

Among cells of the immune system, CD11c(+) and DEC-205(+) splenic dendritic cells primarily express the cellular receptor (alpha-dystroglycan [alpha-DG]) for lymphocytic choriomeningitis virus (LCMV). By selection, strains and variants of LCMV that b

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https://doi.org/10.1084/jem.192.9.1249

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Measles Virus Infection in a Transgenic Model

Autor: John B. Patterson, Andreas Holz, Michael B. A. Oldstone, Antoinette Tishon, Diane Thomas, Mari Manchester, Hanna Lewicki, Samuel Dales, Dirk Homann, Denise Naniche

Publikováno v: Cell. 98(5):629-640

Measles virus (MV) infects 40 million persons and kills one million per year primarily by suppressing the immune system and afflicting the central nervous system (CNS). The lack of a suitable small animal model has impeded progress of understanding h

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In Vivo Treatment with a MHC Class I-Restricted Blocking Peptide Can Prevent Virus-Induced Autoimmune Diabetes

Autor: Matthias G. von Herrath, Bryan Coon, Hanna Lewicki, Honore Mazarguil, Jean Edouard Gairin, Michael B. A. Oldstone

Publikováno v: The Journal of Immunology. 161:5087-5096

We tested the in vivo potential of a MHC class I-restricted blocking peptide to sufficiently lower an anti-viral CTL response for preventing virus-induced CTL-mediated autoimmune diabetes (insulin-dependent diabetes mellitus (IDDM)) in vivo without a

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https://doi.org/10.4049/jimmunol.161.9.5087

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Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

Autor: Xiping Wei, Hanna Lewicki, Jean Edouard Gairin, Heather L. Meyers, Michael B. A. Oldstone, Persephone Borrow, Marc S. Horwitz, George M. Shaw, Nancy J. Peffer, Beatrice H. Hahn, Jay A. Nelson

Publikováno v: Nature Medicine. 3:205-211

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the decline in viremia during primary HIV-1 infection, but definitive evidence that it is of importance in virus containment has been lacking. Here we show that in

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https://doi.org/10.1038/nm0297-205

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