Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hanna Kanerva"'
Publikováno v:
International Journal of Pharmaceutics. 349:24-29
The fate of two colon-specific formulations developed in our previous study was investigated using a gamma scintigraphic imaging method. The formulations contained paracetamol and samarium oxide (Sm 2 O 3) and either microcrystalline cellulose (MCC)
Autor:
Martti Marvola, Aapo Ahonen, Kai Lindevall, Mia Susanna Säkkinen, Janne Marvola, Hanna Kanerva
Publikováno v:
International Journal of Pharmaceutics. 307:285-291
Rapid passage through the proximal intestine can result in the low bioavailability of a drug substance with site-specific absorption characteristics in the upper gastrointestinal tract. To overcome this, there is increasing interest in developing gas
Autor:
Maija Lipponen, Lillian Slot, Sirpa Mykkänen, Kai Lindevall, Janne Marvola, Martti Marvola, Tommi Kekki, Kari Ariniemi, Hanna Kanerva, Heikki Hietanen
Publikováno v:
Marvola, J, Kanerva, H, Slot, L, Lipponen, M, Kekki, T, Hietanen, H, Mykkänen, S, Ariniemi, K, Lindevall, K & Marvola, M 2004, ' Neutron activation-based gamma scintigraphy in pharmacoscintigraphic evaluation of an Egalet ® constant-release drug delivery system ', International Journal of Pharmaceutics, vol. 281, no. 1-2, pp. 3-10 . https://doi.org/10.1016/j.ijpharm.2004.05.022
This paper is a report from a pharmacoscintigraphic study with an Egalet® constant-release system containing caffeine and natural abundance samarium oxide. First the formulation was tested in vitro to clarify integrity during irradiation in the nucl
Autor:
Mia Susanna Säkkinen, Aapo Ahonen, Hanna Kanerva, Kai Lindevall, Janne Marvola, Martti Marvola
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 57:145-147
It is well known that adherence of a drug product, e.g. a gelatine capsule, to the oesophagus can cause oesophageal injury, which can be severe if the medicinal agent has corrosive properties. In a recent study we investigated by means of gamma scint
Publikováno v:
International journal of pharmaceutics. 307(2)
Rapid passage through the proximal intestine can result in the low bioavailability of a drug substance with site-specific absorption characteristics in the upper gastrointestinal tract. To overcome this, there is increasing interest in developing gas
Autor:
Mia Susanna Säkkinen, Martti Marvola, Aapo Ahonen, Hanna Kanerva, Kai Lindevall, Maija Lipponen, Janne Marvola, Tommi Kekki
Publikováno v:
Säkkinen, M, Marvola, J, Kanerva, H, Lindevall, M, Lipponen, M, Kekki, T, Ahonen, A & Marvola, M 2004, ' Gamma scintigraphic evaluation of the fate of microcrystalline chitosan granules in human stomach ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 1, pp. 133-143 . https://doi.org/10.1016/S0939-6411(03)00097-3
In several reports of in vitro studies it has been suggested that the mucoadhesive chitosans could be of value in preparing gastro-retentive formulations. The aim of this study was to obtain direct in vivo evidence of whether microcrystalline chitosa
Autor:
Kai Lindevall, Hanna Kanerva, Tommi Kekki, Outi Honkanen, Martti Marvola, Maija Lipponen, Janne Marvola, Aapo Ahonen
Publikováno v:
Honkanen, O, Marvola, J, Kanerva, H, Lindevall, K, Lipponen, M, Kekki, T, Ahonen, A & Marvola, M 2004, ' Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract ', European Journal of Pharmaceutical Sciences, vol. 21, no. 5, pp. 671-678 . https://doi.org/10.1016/j.ejps.2004.01.008
The fate (movement and disintegration) of hard novel hydroxypropyl methylcellulose (HPMC) two-piece capsules in the human gastrointestinal tract was investigated using a gamma scintigraphic imaging method. Two different prolonged-release formulations