Factors associated with acceleration of clinical development for infectious diseases: a cross-sectional analysis of 10-year EMA registration dataResearch in context

Autor: Hanna K. de Jong, Sabine M. Hermans, Sophie M. Schuitenmaker, Maya Oli, Mariëtte A. van den Hoven, Martin P. Grobusch

Publikováno v: The Lancet Regional Health. Europe, Vol 43, Iss , Pp 100983- (2024)

Summary: Background: Clinical trials feature centrally in the development of drugs and vaccines to determine safety and efficacy. Clinical development can be slow and may have a duration of more than ten years. Global public health threats such as Eb

Externí odkaz: https://doaj.org/article/2583753a7a8b4dfea4b45a416dbc7507

Severe osteoarticular and skin and soft tissue infection with Mycobacterium bovis following intravesical BCG instillation

Autor: Anniek Strijdhorst, L. Charlotte J. de Bree, Reinout van Crevel, Hanna K. de Jong, Sabine M. Hermans

Publikováno v: Clinical Infection in Practice, Vol 22, Iss , Pp 100354- (2024)

We describe the case of a 70-year-old immunocompromised patient who developed a severe disseminated Mycobacterium bovis BCG infection with several infected prosthetic joints and soft tissue abscesses following intravesical BCG instillation for bladde

Externí odkaz: https://doaj.org/article/6dc10a3dcdfc42638af3a3f47b6fbeca

A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

Autor: Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A. Joosten, Corine Prins, Lucia J.M. Kroft, Jacqueline T. Jonker, Stijn Crobach, Rob C. Pelger, Tom H.M. Ottenhoff, Sandra M. Arend

Publikováno v: International Journal of Infectious Diseases, Vol 72, Iss , Pp 63-68 (2018)

Intravesical bacillus Calmette-Guérin (BCG) is widely used for high-risk, non-muscle-invasive bladder cancer. This report describes four cases that illustrate the spectrum of BCG-induced complications, varying from granulomatous prostatitis to sepsi

Externí odkaz: https://doaj.org/article/8c1d9c161de041498512d2d766ad2ef1

Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities

Autor: Eva L. Koekenbier, Konstantin Fohse, Josephine S. van de Maat, Jan Jelrik Oosterheert, Cees van Nieuwkoop, Jacobien J. Hoogerwerf, Martin P. Grobusch, Maurice A.A.J. van den Bosch, Janneke H.H. van de Wijgert, Mihai G. Netea, Frits R. Rosendaal, Marc J.M. Bonten, C.H. (Henri) van Werkhoven, Astrid Aardenburg-van Huisstede, Heidi S.M. Ammerlaan, Willem G. Boersma, Kees Brinkman, Patricia C.J. Bruijning-Verhagen, Reinout van Crevel, Corine Delsing, Thijs ten Doesschaten, Anton S.M. Dofferhoff, Ruud Duijkers, Rolf H.H. Groenwold, Corine de Haas, Robert-Jan Hassing, Marieke L.A. de Hoog, Susanne M. Huijts, Astrid van Hylckama-Vlieg, Eefje Jong, Hanna K. de Jong, Martijn Knap, Michael Koenders, Ilse J.E. Kouijzer, Henk Kramer, Roel van de Laar, Arief Lalmohamed, Karel-Jan D.F. Lensen, Willem M. Lijfering, Fabienne Magdelijns, Bob Meek, Rutger A. Middelburg, Hazra S. Moeniralam, Simon P. Mooijaart, Barbara C. van Munster, Jaap ten Oever, Marc Padros Goossens, Vincent Peters, Douwe F. Postma, Niels Pouw, Herre J. Reesink, Marieke J.A. de Regt, Anneli C.J. van der Reijden, R. Schaakxs, Kitty Slieker, Robbert J. Slingerland, Nicolette L.J. van Sluis, Coen D.A. Stehouwer, Frank van de Veerdonk, Annelies Verbon

Publikováno v: Clinical Microbiology and Infection, 29, 6, pp. 781-788
Clinical Microbiology and Infection. ELSEVIER SCI LTD
Clinical microbiology and infection. Elsevier Limited
Clinical Microbiology and Infection, 29, 781-788

Contains fulltext : 293489.pdf (Publisher’s version ) (Open Access) OBJECTIVES: To test whether Bacillus Calmette-Guérin (BCG) vaccination would reduce the incidence of COVID-19 and other respiratory tract infections (RTIs) in older adults with on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8c3a684309d13bffc06a6419df8592
https://doi.org/10.1016/j.cmi.2023.01.019

Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

Autor: Elin Näsström, Christopher M Parry, Nga Tran Vu Thieu, Rapeephan R Maude, Hanna K de Jong, Masako Fukushima, Olena Rzhepishevska, Florian Marks, Ursula Panzner, Justin Im, Hyonjin Jeon, Seeun Park, Zabeen Chaudhury, Aniruddha Ghose, Rasheda Samad, Tan Trinh Van, Anders Johansson, Arjen M Dondorp, Guy E Thwaites, Abul Faiz, Henrik Antti, Stephen Baker

Publikováno v: eLife, Vol 6 (2017)

Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid pat

Externí odkaz: https://doaj.org/article/6fd4d94a49cf4cbaaf631d8b3f61ea6d