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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.

Autor: Caldwell N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Peet C; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Miller P; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Colon BL; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Taylor MG; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Cocco M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dawson A; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Lukac I; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Teixeira JE; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Robinson L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frame L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Seizova S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Damerow S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tamaki F; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Post J; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Riley J; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Mutter N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hanna JC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Ferguson L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hu X; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tinti M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Forte B; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Norcross NR; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Campbell PS; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Svensen N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Caldwell FC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Jansen C; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Postis V; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Read KD; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Huston CD; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Gilbert IH; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Baragaña B; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Pawlowic MC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Oct 23; Vol. 16 (770), pp. eadm8631. Date of Electronic Publication: 2024 Oct 23.

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium .

Autor: Hanna JC; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Corpas-Lopez V; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Seizova S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Colon BL; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Bacchetti R; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Hall GMJ; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Sands EM; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Robinson L; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Baragaña B; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Wyllie S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Pawlowic MC; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Aug 04; Vol. 13, pp. 1236814. Date of Electronic Publication: 2023 Aug 04 (Print Publication: 2023).

A South Pole-Aitken impact origin of the lunar compositional asymmetry.

Autor: Jones MJ; Department of Earth, Environmental and Planetary Sciences, Brown University, Box 1846, 324 Brook Street, Providence, RI 02912, USA., Evans AJ; Department of Earth, Environmental and Planetary Sciences, Brown University, Box 1846, 324 Brook Street, Providence, RI 02912, USA., Johnson BC; Department of Earth, Atmospheric, and Planetary Sciences, Purdue University, West Lafayette, IN 47907, USA.; Department of Physics and Astronomy, Purdue University, West Lafayette, IN 47907, USA., Weller MB; Department of Earth, Environmental and Planetary Sciences, Brown University, Box 1846, 324 Brook Street, Providence, RI 02912, USA.; Lunar and Planetary Institute, Houston, TX 77058, USA., Andrews-Hanna JC; Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA., Tikoo SM; Department of Geophysics, Stanford University, Stanford, CA 94305, USA., Keane JT; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.

Publikováno v: Science advances [Sci Adv] 2022 Apr 08; Vol. 8 (14), pp. eabm8475. Date of Electronic Publication: 2022 Apr 08.

Exenatide induces carcinoembryonic antigen-related cell adhesion molecule 1 expression to prevent hepatic steatosis.

Autor: Ghadieh HE; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Muturi HT; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH., Russo L; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Marino CC; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Ghanem SS; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Khuder SS; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Hanna JC; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH., Jash S; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH., Puri V; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH.; Diabetes Institute, Heritage College of Osteopathic Medicine Ohio University Athens OH., Heinrich G; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH.; Diabetes Institute, Heritage College of Osteopathic Medicine Ohio University Athens OH., Gatto-Weis C; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH.; Department of Pathology, College of Medicine and Life Sciences University of Toledo Toledo OH., Lee KY; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH., Najjar SM; Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences University of Toledo Toledo OH.; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine Ohio University Athens OH.; Diabetes Institute, Heritage College of Osteopathic Medicine Ohio University Athens OH.

Publikováno v: Hepatology communications [Hepatol Commun] 2017 Nov 02; Vol. 2 (1), pp. 35-47. Date of Electronic Publication: 2017 Nov 02 (Print Publication: 2018).