Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hanna I. Filutowicz"'
Autor:
Marc K. Jenkins, George S. Deepe, Hanna I. Filutowicz, Mengyi Li, Bruce S. Klein, Marcel Wüthrich, Jennifer A Walter, Alana K. Sterkel, Tassanee Lerksuthirat, Douglas Stewart, Vanessa LeBert, T. Tristan Brandhorst, Gary R. Ostroff, Garry T. Cole, Zu Ting Shen, Thomas D. Sullivan, Chiung Yu Hung
Publikováno v:
Cell Host & Microbe. 17:452-465
Summary Fungal infections remain a threat due to the lack of broad-spectrum fungal vaccines and protective antigens. Recent studies showed that attenuated Blastomyces dermatitidis confers protection via T cell recognition of an unknown but conserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ade3228c49e57cbbc522be827d6cb5a
https://doi.org/10.1016/j.chom.2015.02.009
https://doi.org/10.1016/j.chom.2015.02.009
Autor:
Benjamin H. Gern, John C. Pick-Jacobs, Karen Ersland, Thomas D. Sullivan, Christopher A. Frye, Marcel Wüthrich, Bruce S. Klein, Keegan Korthauer, Meghan B. Brennan, Kevin O'Brien, Hanna I. Filutowicz, Stacey L. Schultz-Cherry
Publikováno v:
Infection and Immunity. 80:787-797
CD4 + T cells are the key players of vaccine resistance to fungi. The generation of effective T cell-based vaccines requires an understanding of how to induce and maintain CD4 + T cells and memory. The kinetics of fungal antigen (Ag)-specific CD4 + T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd2fe7fa2f3f6db6d919cd8811648ced
https://doi.org/10.1128/iai.05326-11
https://doi.org/10.1128/iai.05326-11
Autor:
Hanna I. Filutowicz, Valerie I. Shearn-Bochsler, Chris Bass, Marcel Wüthrich, Alfred M. Legendre, Theerapong Krajaejun, Bruce S. Klein
Publikováno v:
Clinical and Vaccine Immunology. 18:783-789
Blastomycosis is a severe, commonly fatal infection caused by the dimorphic fungus Blastomyces dermatitidis in dogs that live in the United States, Canada, and parts of Africa. The cost of treating an infection can be expensive, and no vaccine agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f544e4cb07ea3f3f9d3b34f42a6f84b4
https://doi.org/10.1128/cvi.00560-10
https://doi.org/10.1128/cvi.00560-10
Publikováno v:
Infection and Immunity. 75:193-200
Immunization with a cell wall/membrane (CW/M) and yeast cytosol extract (YCE) crude antigen from Blastomyces dermatitidis confers T-cell-mediated resistance against lethal experimental infection in mice. We isolated and characterized T cells that rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d97b75fd0624ae14eea498c78567eb
https://doi.org/10.1128/iai.01148-06
https://doi.org/10.1128/iai.01148-06
Autor:
Marcel Wüthrich, Bruce S. Klein, Beatriz Finkel-Jimenez, Thomas F. Warner, Hanna I. Filutowicz, T. Tristan Brandhorst
Publikováno v:
Medical Mycology. 44:41-49
The adhesin BAD1 is required for virulence of Blastomyces dermatitidis in a pulmonary model of infection. Herein, we explored mechanisms by which BAD1 enhances pathogenicity of the fungus. Isogenic strains with and without BAD1 exhibited similar phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013f6591c86b20e1dfe29c9ce343243
https://doi.org/10.1080/13693780500220217
https://doi.org/10.1080/13693780500220217
Publikováno v:
The Journal of Experimental Medicine
Systemic fungal infections with primary and opportunistic pathogens have become increasingly common and represent a growing health menace in patients with AIDS and other immune deficiencies. T lymphocyte immunity, in particular the CD4+ Th 1 cells, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30be41530526db268fdb45ab0bb29fb
http://europepmc.org/articles/PMC2193905
http://europepmc.org/articles/PMC2193905
Publikováno v:
The Journal of Immunology. 169:6969-6976
Understanding fundamental mechanisms of vaccine immunity will allow proper use and optimization of vaccines. Vaccination with a genetically engineered, live, attenuated strain of Blastomyces dermatitidis carrying a targeted deletion at the BAD1 locus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab05dff7aeff8ae13d2ce75d5a1149f
https://doi.org/10.4049/jimmunol.169.12.6969
https://doi.org/10.4049/jimmunol.169.12.6969
Autor:
Bruce S. Klein, Marcel Wüthrich, Chiung Yu Hung, Kevin Galles, Nicole Rocco, John C. Pick-Jacobs, Thomas F. Warner, Karen Ersland, Garry T. Cole, Hanna I. Filutowicz, Michael D. Evans, Benjamin H. Gern
Publikováno v:
Journal of Clinical Investigation. 126:795-795
Worldwide rates of systemic fungal infections, including three of the major pathogens responsible for such infections in North America (Coccidioides posadasii, Histoplasma capsulatum, and Blastomyces dermatitidis), have soared recently, spurring inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2f4320fb52ac0794fe8d32823e5a01
https://doi.org/10.1172/jci85788
https://doi.org/10.1172/jci85788
Autor:
Garry T. Cole, Chiung Yu Hung, Marcel Wüthrich, Bruce S. Klein, Hanna I. Filutowicz, John C. Pick-Jacobs, Ben H. Gern, Kevin Galles
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(3)
Dimorphic fungi collectively account for 5–10 million new infections annually worldwide. Ongoing efforts seek to clarify mechanisms of cellular resistance to these agents and develop vaccines. A major limitation in studying the development of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c2818f53305fbf444ae159aea4f708
https://pubmed.ncbi.nlm.nih.gov/21705621
https://pubmed.ncbi.nlm.nih.gov/21705621
Publikováno v:
Infection and Immunity. 58:107-113
Germfree athymic (nu/nu) and euthymic (nu/+) mice were colonized with a pure culture of Candida albicans. Correlates of cell-mediated immunity (lymphocyte proliferation and footpad responses to C. albicans antigens) and in vivo clearance of mucosal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d76c31abc9b58fe8ceea786a269e416
https://doi.org/10.1128/iai.58.1.107-113.1990
https://doi.org/10.1128/iai.58.1.107-113.1990