Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Hanna Harant"'
Autor:
Hanna Harant
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7246 (2022)
The effect of the antiviral peptide TAT-I24 on viral gene expression in cells infected with murine cytomegalovirus (MCMV) was investigated. The expression of immediate-early, early and late genes was highly induced upon infection with MCMV. In the pr
Externí odkaz:
https://doaj.org/article/e915ff4bc68844c190dada6586ea25c9
A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication
Autor:
Zsolt Ruzsics, Katja Hoffmann, André Riedl, Adalbert Krawczyk, Marek Widera, Helene Sertznig, Leonie Schipper, Valeria Kapper-Falcone, Monika Debreczeny, Wolfgang Ernst, Reingard Grabherr, Hartmut Hengel, Hanna Harant
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options,
Externí odkaz:
https://doaj.org/article/096248e7258547dfb6f0e791f893b10a
Autor:
Franz Kricek, Ivan J. D. Lindley, Hartmut Hengel, Siegfried Höfinger, Zsolt Ruzsics, Christine Ruf, Hanna Harant
Publikováno v:
Biologics
Volume 1
Issue 1
Pages 3-60
Volume 1
Issue 1
Pages 3-60
The peptide TAT-I24, composed of the 9-mer peptide I24 and the TAT (48-60) peptide, exerts broad-spectrum antiviral activity against several DNA viruses. The current model of the mode of action suggests a reduction of viral entry and also a possible
Autor:
Stig Linder, Michela Piacenti, Sabine L. Flitsch, Alina Mares, Anna C. Callan, Peristera Roboti, Stephen High, Roger C. Whitehead, Karolina Lesiak-Mieczkowska, Hanna Harant, Marjo Puumalainen, Eileithyia Swanton, Craig McKibbin, Helen L. Williams
Publikováno v:
Biochemical Journal
Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ESI (eeyarestatin I) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we show that in addition to acute
Autor:
Florian Forster, Marcela Hermann, Irina Korschineck, Albert Missbichler, Hanna Harant, Valerie Stadlmann
Publikováno v:
BMC Biotechnology
Background Celiac disease (CD) is a chronic, small intestinal inflammatory disease mediated by dietary gluten and related prolamins. The only current therapeutic option is maintenance of a strict life-long gluten-free diet, which implies substantial
Autor:
Jozef Ban, Susanne Karner, Erwin Tschachler, Maria Buchberger, Michael Mildner, Paul Mrass, Claudia Ballaun, Hanna Harant, Leopold Eckhart, Jürgen Bach
Publikováno v:
Biochemical and Biophysical Research Communications. 371:261-266
Caspase-14, a protease involved in skin barrier formation, is specifically expressed in epidermal keratinocytes (KCs). Here, we mapped three start sites of transcription of the human caspase-14 gene and analyzed the upstream chromosomal region for pr
Autor:
Berndt Oberhauser, Hanna Harant, Christiane Dascher-Nadel, Katharina Marquardt, Erwin P. Schreiner, Ivan J. D. Lindley, Shirley Wang, Jan E. de Vries, Carolyn A. Foster, Jürgen Besemer
Publikováno v:
Nature. 436:290-293
Increased expression of vascular cell adhesion molecule 1 (VCAM1) is associated with a variety of chronic inflammatory conditions, making its expression and function a target for therapeutic intervention1,2,3. We have recently identified CAM741, a de
Autor:
Ivan J. D. Lindley, Hanna Harant
Publikováno v:
Nucleic Acids Research. 32:5280-5290
The effect of orphan nuclear receptor Nur77 overexpression on activation of an interleukin-2 (IL-2) promoter-luciferase construct was analyzed in the human leukemic cell line Jurkat. Cotransfection of the IL-2 promoter construct together with the Nur
Autor:
Rainer de Martin, Ivan J. D. Lindley, Renate Hofer-Warbinek, Johannes A. Schmid, Florian Gruber, Bernd R. Binder, Renate Huber-Beckmann, Markus Lucerna, Nikolina Papac, Hanna Harant, Peter Hufnagl, Johannes M. Breuss
Publikováno v:
Blood. 101:3042-3048
Plasminogen activator inhibitor 1 (PAI-1) is the main fibrinolysis inhibitor, and high plasma levels are associated with an increased risk for vascular diseases. Inflammatory cytokines regulate PAI-1 through a hitherto unclear mechanism. Using report
Publikováno v:
FEBS Letters. 509:439-445
The 5'-flanking sequences of the human macrophage inflammatory protein-3alpha/CCL20 gene were cloned and transfected into G-361 human melanoma cells in a luciferase reporter construct. Tumor necrosis factor-alpha (TNF-alpha) treatment stimulated luci