Výsledky vyhledávání - "Hanna Erdmann"

Akademický článek

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

Autor: Philipp Stüve, Lucía Minarrieta, Hanna Erdmann, Catharina Arnold-Schrauf, Maxine Swallow, Melanie Guderian, Freyja Krull, Alexandra Hölscher, Peyman Ghorbani, Jochen Behrends, Wolf-Rainer Abraham, Christoph Hölscher, Tim D. Sparwasser, Luciana Berod

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to efficiently manipulate the host immune system establishing chronic infection, yet the underlying mechanisms of immune evasion are not fully understood. Evidence s

Externí odkaz: https://doaj.org/article/8f8f910f03db44969c21545058c3b1ac

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Akademický článek

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis

Autor: Erik Schmok, Mahin Abad Dar, Jochen Behrends, Hanna Erdmann, Dominik Rückerl, Tanja Endermann, Lisa Heitmann, Manuela Hessmann, Akihiko Yoshimura, Stefan Rose-John, Jürgen Scheller, Ulrich Emil Schaible, Stefan Ehlers, Roland Lang, Christoph Hölscher

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxi

Externí odkaz: https://doaj.org/article/203401a6a1f745aaa490237d09c7d434

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Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A

Autor: Thomas Lindenstrøm, Christoph Hölscher, Jasmin Rousseau, Immo Prinz, Hanna Erdmann, Johanna Volz, Jochen Behrends, Alexandra Hölscher, Kristina Ritter

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)

Interleukin (IL)-17A-producing T helper (Th)17 cells are increasingly being acknowledged to be associated with protective immunity toMycobacterium tuberculosis(Mtb). Subunit vaccines potently promote protective immune responses against Mtb infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc400a6a6e8be012b5901d89607ab957
http://europepmc.org/articles/PMC8541990

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Correction to: Interleukin‑23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin‑17A

Autor: Kristina Ritter, Jochen Behrends, Hanna Erdmann, Jasmin Rousseau, Alexandra Hölscher, Johanna Volz, Immo Prinz, Thomas Lindenstrøm, Christoph Hölscher

Publikováno v: J Mol Med (Berl)

Interleukin (IL)-17A-producing T helper (Th)17 cells are increasingly being acknowledged to be associated with protective immunity to Mycobacterium tuberculosis (Mtb). Subunit vaccines potently promote protective immune responses against Mtb infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ba76bc3804eddd9174e11dc8125d8
https://doi.org/10.1007/s00109-021-02142-7

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Epstein– B arr virus‐induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after T rypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation

Autor: Julia Böhme, Hanna Erdmann, Caroline Roßnagel, Jochen Behrends, Thomas Jacobs, Christoph Hölscher

Publikováno v: Immunology. 147:338-348

The Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL)-12) family structurally related to the subunit p40 of IL-12 and forms a heterodimer either with the p28 subunit to build IL-27 or with p35 to form IL-35. Interleukin-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff931389a23cf3c1b41939d409a5cc34
https://doi.org/10.1111/imm.12565

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De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

Autor: Jochen Behrends, Hanna Erdmann, Tim Sparwasser, Freyja Krull, Peyman Ghorbani, Lucía Minarrieta, Maxine Swallow, Christoph Hölscher, Melanie Guderian, Alexandra Hölscher, Luciana Berod, Catharina Arnold-Schrauf, Wolf-Rainer Abraham, Philipp Stüve

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in immunology
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b345235db001ec46c7592840adbb6515
https://doi.org/10.3389/fimmu.2018.00495

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The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells

Autor: Jochen Behrends, Johanna Volz, Hanna Erdmann, Kristina Ritter, Christoph Hölscher, Alexandra Hölscher, Ida Rosenkrands

Publikováno v: Mucosal immunology. 11(4)

During Mycobacterium tuberculosis (Mtb) infection, mice lacking the IL-27R exhibit lower bacterial burdens but develop an immunopathological sequelae in comparison to wild-type mice. We here show that this phenotype correlates with an enhanced recrui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629d41472e54c61d0575a1254dd1f1f7
https://pubmed.ncbi.nlm.nih.gov/29728641

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9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

Autor: Mahin Abad Dar, Franziska Maiwald, Diego Benítez, Laurent Meijer, Nadège Loaëc, Conrad Kunick, Lutz Preu, Hanna Erdmann, Marcelo A. Comini, Oliver Koch, Diego Charquero, Christoph Hölscher

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.274-283. ⟨10.1016/j.ejmech.2014.06.020⟩

International audience; Trypanosomes from the "brucei" complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock. In order to identify new antitrypanosomal chemotypes against Africa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f950885441e6cd8f086d1dfed0feca
https://doi.org/10.1016/j.ejmech.2014.06.020

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IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment

Autor: Ulrich E. Schaible, Christoph Hölscher, Julia Böhme, Yoichiro Iwakura, Thomas Jacobs, Caroline Roßnagel, Hanna Erdmann

Publikováno v: Immunobiology. 218:910-923

The contribution of the IL-23–IL-17A pathway to resistance against extracellular bacterial infections is well established, whereas its role in immunity to intracellular pathogens is much less clear. To analyze the contribution of the IL-23–IL-17A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11581775ed98f89719e13504ee0cb43e
https://doi.org/10.1016/j.imbio.2012.10.005

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During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection

Autor: Hanna Erdmann, Christoph Hölscher, Jochen Behrends

Publikováno v: Scientific Reports

Protective immunity against Trypanosoma cruzi, the causative agent of Chagas disease, depends on the activation of macrophages by IFN-γ and IL-17A. In contrast, IL-10 prevents immunopathology. IL-22 belongs to the IL-10 cytokine family and has pleio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47fac4b9a794b191bf670f19533f7c1

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