Impact of time to antibiotics on clinical outcome in paediatric febrile neutropenia: a target trial emulation of 1685 episodes.

Autor: Haeusler GM; Department of Infectious Diseases, Royal Children's Hospital, Parkville, Victoria, Australia.; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.; The Paediatric Integrated Cancer Service, Victoria State Government, Parkville, Australia., Dashti SG; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia., James F; Murdoch Children's Research Institute, Parkville, Victoria, Australia., Babl FE; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.; Emergency Department, Royal Children's Hospital, Parkville, Victoria, Australia., Borland ML; Emergency Department, Perth Children's Hospital, Nedlands, Western Australia, Australia.; School of Medicine, Divisions of Emergency Medicine and Paediatrics, University of Western Australia, Crawley, Western Australia, Australia., Clark JE; Infection Management, Queensland Children's Hospital, Brisbane, Queensland, Australia.; Children's Health Queensland Clinical Unit, University of Queensland, Queensland, Australia., Padhye B; Cancer Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.; Kids Research, Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead, New South Wales, Australia., Tapp H; Department of Oncology, Women's and Children's Hospital, Adelaide, South Australia, Australia., Alvaro F; Children's Cancer and Blood Disorders, John Hunter Children's Hospital, Newcastle, New South Wales, Australia., Raj TS; Children's Health Queensland Clinical Unit, University of Queensland, Queensland, Australia.; Oncology Services Group, Queensland Children's Hospital, Queensland, Australia., Walwyn T; Department of Oncology, Perth Children's Hospital, Perth, Western Australia, Australia.; Department of Paediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia., Super L; Children's Cancer Centre, Royal Children's Hospital, Parkville, Victoria, Australia.; Children's Cancer Centre, Monash Children's Hospital, Clayton, Victoria, Australia., Hall L; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; School of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Yeoh DK; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, Western Australia, Australia., Butters C; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.; Department of General Paediatrics and Adolescent Medicine, John Hunter Children's Hospital, Australia., McMullan B; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.; Department of Infectious Diseases, Sydney Children's Hospital Randwick, Sydney, New South Wales, Australia., Hanna DMT; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.; Children's Cancer Centre, Royal Children's Hospital, Parkville, Victoria, Australia., De Abreu Lourenco R; Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, New South Wales, Australia., Slavin MA; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Phillips B; Centre for Reviews and Dissemination and Hull-York Medical School, York, UK.; Regional Department of Haematology and Oncology, Leeds Children's Hospital, Leeds, UK., Thursky KA; Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; NHMRC National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; NHMRC National Centre for Antimicrobial Stewardship, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Publikováno v: The Lancet regional health. Western Pacific [Lancet Reg Health West Pac] 2024 Nov 02; Vol. 53, pp. 101226. Date of Electronic Publication: 2024 Nov 02 (Print Publication: 2024).