Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hanna C.A. Lammertse"'
Autor:
Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica A. Classen, Hanna C.A. Lammertse, Lola A. van Linge, Desiree Schut, Tamara Krutenko, Matthias Hebisch, L. Niels Cornelisse, Patrick F. Sullivan, Michael Peitz, Ruud F. Toonen, Oliver Brüstle, Matthijs Verhage
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2199-2211.e6 (2019)
Summary: Synaptic dysfunction is associated with many brain disorders, but robust human cell models to study synaptic transmission and plasticity are lacking. Instead, current in vitro studies on human neurons typically rely on spontaneous synaptic e
Externí odkaz:
https://doaj.org/article/20c05e78a6744a9bb42bc89f2c5fbe99
Autor:
Tim S. Heistek, Ioannis Kramvis, Sabine Spijker, Alex Loebel, Danai Riga, Huibert D. Mansvelder, Hanna C.A. Lammertse, Rhodé van Westen, Rhiannon M. Meredith
Publikováno v:
Kramvis, I, van Westen, R, Lammertse, H C A, Riga, D, Heistek, T S, Loebel, A, Spijker, S, Mansvelder, H D & Meredith, R M 2020, ' Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model ', Frontiers in Molecular Neuroscience, vol. 13, no. May, 88, pp. 1-16 . https://doi.org/10.3389/fnmol.2020.00088
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, 13(May):88, 1-16. Frontiers Media S.A.
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, 13(May):88, 1-16. Frontiers Media S.A.
Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognit
Autor:
Pasquale Striano, Michele Iacomino, Annemiek A. van Berkel, Antonio Gambardella, Ruud F. Toonen, Matthijs Verhage, Federico Zara, Hanna C.A. Lammertse
Publikováno v:
Lammertse, H C A, van Berkel, A A, Iacomino, M, Toonen, R F, Striano, P, Gambardella, A, Verhage, M & Zara, F 2020, ' Homozygous STXBP1 variant causes encephalopathy and gain-of-function in synaptic transmission ', Brain, vol. 143, no. 2, pp. 441-451 . https://doi.org/10.1093/brain/awz391
Brain, 143(2), 441-451. Oxford University Press
Brain
Brain, 143(2), 441-451. Oxford University Press
Brain
Heterozygous STXBP1 mutations are associated with severe neurodevelopmental symptoms. Lammertse et al. describe a homozygous STXBP1 variant that causes clinical features of Lennox-Gastaut syndrome, and show that the functional consequences of this mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7977504bdaf000a337088f8f80c0555
https://hdl.handle.net/1871.1/86f2ab2f-06ea-44ef-93c3-3d6f5fdc6670
https://hdl.handle.net/1871.1/86f2ab2f-06ea-44ef-93c3-3d6f5fdc6670
Autor:
Ruud F. Toonen, Jan R.T. van Weering, Thomas H. Söllner, Matthijs Verhage, Bernhard Dörr, Chrysanthi Blithikioti, Marieke Meijer, Hanna C.A. Lammertse
Publikováno v:
Meijer, M, Dörr, B, Lammertse, H C, Blithikioti, C, van Weering, J R, Toonen, R F, Söllner, T H & Verhage, M 2018, ' Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly ', EMBO Journal, vol. 37, no. 2, pp. 300-320 . https://doi.org/10.15252/embj.201796484
EMBO Journal, 37(2), 300-320. Nature Publishing Group
Meijer, M, Dörr, B, Lammertse, H C A, Blithikioti, C, van Weering, J R T, Toonen, R F G, Söllner, T H & Verhage, M 2018, ' Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly ', EMBO Journal, vol. 37, no. 2, pp. 300-320 . https://doi.org/10.15252/embj.201796484
EMBO Journal, 37(2), 300-320. Wiley-Blackwell
The EMBO Journal
EMBO Journal, 37(2), 300-320. Nature Publishing Group
Meijer, M, Dörr, B, Lammertse, H C A, Blithikioti, C, van Weering, J R T, Toonen, R F G, Söllner, T H & Verhage, M 2018, ' Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly ', EMBO Journal, vol. 37, no. 2, pp. 300-320 . https://doi.org/10.15252/embj.201796484
EMBO Journal, 37(2), 300-320. Wiley-Blackwell
The EMBO Journal
Tyrosine kinases are important regulators of synaptic strength. Here, we describe a key component of the synaptic vesicle release machinery, Munc18-1, as a phosphorylation target for neuronal Src family kinases (SFKs). Phosphomimetic Y473D mutation o
Autor:
L. Niels Cornelisse, Hanna C.A. Lammertse, Ruud F. Toonen, Oliver Brüstle, Tamara Krutenko, Marieke Meijer, Kristina Rehbach, Jessie W. Brunner, Jessica Classen, Patrick F. Sullivan, Desiree Schut, Matthias Hebisch, Matthijs Verhage, Michael Peitz, Lola A. van Linge
Publikováno v:
Cell Reports
Cell Reports, Vol 27, Iss 7, Pp 2199-2211.e6 (2019)
Cell Reports, 27(7), 2199-2211.e6. Cell Press
Meijer, M, Rehbach, K, Brunner, J W, Classen, J A, Lammertse, H C A, van Linge, L A, Schut, D, Krutenko, T, Hebisch, M, Cornelisse, L N, Sullivan, P F, Peitz, M, Toonen, R F, Brüstle, O & Verhage, M 2019, ' A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons ', Cell Reports, vol. 27, no. 7, pp. 2199-2211.e6 . https://doi.org/10.1016/j.celrep.2019.04.058
Cell Reports, Vol 27, Iss 7, Pp 2199-2211.e6 (2019)
Cell Reports, 27(7), 2199-2211.e6. Cell Press
Meijer, M, Rehbach, K, Brunner, J W, Classen, J A, Lammertse, H C A, van Linge, L A, Schut, D, Krutenko, T, Hebisch, M, Cornelisse, L N, Sullivan, P F, Peitz, M, Toonen, R F, Brüstle, O & Verhage, M 2019, ' A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons ', Cell Reports, vol. 27, no. 7, pp. 2199-2211.e6 . https://doi.org/10.1016/j.celrep.2019.04.058
Summary: Synaptic dysfunction is associated with many brain disorders, but robust human cell models to study synaptic transmission and plasticity are lacking. Instead, current in vitro studies on human neurons typically rely on spontaneous synaptic e