Výsledky vyhledávání - "Hanna Bitner"

Data from The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway

Autor: Arnon Nagler, Amnon Peled, Eithan Galun, Michal Abraham, Hanna Wald, Lola Weiss, Devorah Olam, Shiri Klein, Elena Ribakovsky, Maya Koren-Michowitz, Merav Leiba, Avichai Shimoni, Hanna Bitner, Evgenia Rosenberg, Katia Beider

Purpose: To explore the functional consequences of possible cross-talk between the CXCR4/CXCL12 and the sphingosine-1-phosphate (S1P) pathways in multiple myeloma (MM) cells and to evaluate the effect of S1P targeting with the FTY720 modulator as a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca9eb97bd487d7d584a79b6366d3d5c
https://doi.org/10.1158/1078-0432.c.6523479.v1

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The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators

Autor: Lola Weiss, Valeria Voevoda-Dimenshtein, Avichai Shimoni, Evgenia Rosenberg, Jonathan Canaani, Michal Abraham, Amnon Peled, Hila Magen, Yaarit Sirovsky, Arnon Nagler, Olga Ostrovsky, Noya Shilo, Katia Beider, Michael Milyavsky, Hanna Bitner

Publikováno v: Biochemical pharmacology. 168

Although having promising anti-myeloma properties, the pan-histone deacetylase inhibitor (HDACi) panobinostat lacks therapeutic activity as a single agent. The aim of the current study was to elucidate the mechanisms underlying multiple myeloma (MM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98533f2f17bdb27f1e83333a04a6e7aa
https://pubmed.ncbi.nlm.nih.gov/31325448

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Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype

Autor: Amnon Peled, Odit Gutwein, Hanna Wald, Katia Beider, Olga Ostrovsky, Arnon Nagler, Eithan Galun, Maya Koren-Michowitz, Hanna Bitner, Michal Abraham, Merav Leiba

Publikováno v: Oncotarget

// Katia Beider 1 , Hanna Bitner 1 , Merav Leiba 1 , Odit Gutwein 1 , Maya Koren-Michowitz 1 , Olga Ostrovsky 1 , Michal Abraham 3 , Hanna Wald 3 , Eithan Galun 2 , Amnon Peled 2 and Arnon Nagler 1 1 Hematology Division and CBB, Guy Weinshtock Multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d66adf923ef23163cb69b67e5ff13c
http://europepmc.org/articles/PMC4294328

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Inhibition of WIP1 Phosphatase in Multiple Myeloma Overcomes Bortezomib Resistance and Promotes Cell Death Via ER Stress-Induced Apoptotic JNK/c-Jun Signaling and Downregulation of Inhibitors of Apoptosis Proteins (IAPs)

Autor: Avichai Shimoni, Amnon Peled, Hila Magen, Evgenia Rosenberg, Hanna Bitner, Katia Beider, Yaarit Sirovsky, Olga Ostrovsky, Valeria Voevoda, Michael Milyavsky, Arnon Nagler

Publikováno v: Blood. 132:1366-1366

Acquired or de novo resistance to the traditional and novel anti-multiple myeloma (MM) agents remains a major treatment obstacle, therefore novel therapies are in need. Wild-type p53-induced phosphatase 1 (WIP1) is an oncogenic serine/threonine phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::505b395d6ec908d55ea7abb77ca4c1b5
https://doi.org/10.1182/blood-2018-99-114652

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The mTOR Inhibitor Everolimus Overcomes CXCR4-Mediated Resistance to HDAC Inhibitor Panobinostat through Inhibition of p21 and Mitosis Regulators, Sensitizing MM Cells to DNA-Damaged Induced Apoptosis

Autor: Katia Beider, Valeria Voevoda, Hila Magen, Avichai Shimoni, Hanna Bitner, Olga Ostrovsky, Evgenia Rosenberg, Amnon Peled, Noya Shilo, Arnon Nagler, Michael Milyavsky, Merav Leiba

Publikováno v: Blood. 128:891-891

Introduction: Multiple myeloma (MM) is a neoplastic disorder that is characterized by clonal proliferation of plasma cells in the bone marrow (BM). Despite the initial efficacious treatment, MM patients often become refractory to common anti-MM drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae784f3b683257ad90e9bcad189dfa3a
https://doi.org/10.1182/blood.v128.22.891.891

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Anti-Human T-Lymphocyte Immunoglobulin (ATG)-Induced T Regulatory Cells and Their Soluble Factors Suppress T Cell Proliferation: Potential Role in Allogeneic Stem Cell Transplantation

Autor: Katia Beider, David Naor, Nira Bloom, Avichai Shimoni, Olga Ostrovsky, Hanna Bitner, Valeria Voevoda, Evgenia Rosenberg, Simone Tal, Ivetta Danilesko, Arnon Nagler

Publikováno v: Blood. 126:1889-1889

Polyclonal anti-human T-lymphocyte immunoglobulin(ATG) have been recently shown, in two randomized studies, to significantly reduce the incidence of graft versus host disease (GVHD) post allogeneic stem cell transplantation (HSCT) from both sibling a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa22a12d701761e1b498ed669f2914c9
https://doi.org/10.1182/blood.v126.23.1889.1889

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Evaluation of macular structure and function by OCT and electrophysiology in patients with vitelliform macular dystrophy due to mutations in BEST1

Autor: Sten Andréasson, Birgit Sander, Stig K. Holfort, Michael Larsen, Patrik Schatz, Hanna Bitner, Dror Sharon

Publikováno v: Investigative ophthalmologyvisual science. 51(9)

PURPOSE. To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. METHODS. Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a553c7f9854c55262d511294676b6e
https://pubmed.ncbi.nlm.nih.gov/20375334

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S1P Modulator FTY720 Targets Multiple Myeloma Cell Proliferation and Stromal Interactions Via CXCR4/CXCL12 and mTOR Pathways

Autor: Hanna Wald, Avichai Shimoni, Shiri Klein, Arnon Nagler, Merav Leiba, Evgenia Rosenberg, Michal Abraham, Amnon Peled, Katia Beider, Hanna Bitner, Maya Koren-Michowitz

Publikováno v: Blood. 124:4707-4707

Introduction: Multiple myeloma (MM) is an incurable hematological malignancy characterized by proliferation of malignant plasma cells in the bone marrow (BM). Interactions between MM cells and BM milieu facilitate disease progression and therapy resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc13655ae0b15685bb39312f93af0b4f
https://doi.org/10.1182/blood.v124.21.4707.4707

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Frequency, Genotype, and Clinical Spectrum of Best Vitelliform Macular Dystrophy: Data From a National Center in Denmark

Autor: Thomas Rosenberg, Dror Sharon, Liliana Mizrahi-Meissonnier, Hanna Bitner, Patrik Schatz

Publikováno v: American Journal of Ophthalmology; 154(2), pp 403-412 (2012)

PURPOSE: To estimate the prevalence, genotype, and clinical spectrum of Best vitelliform macular dystrophy (Best disease). DESIGN: Retrospective epidemiologic and clinical and molecular genetic observational study. METHODS: SETTING: National referral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737212435ab45622f7e7e95d487a50c2
https://doi.org/10.1016/j.ajo.2012.02.036

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