Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hanna Bielarczyk"'
Autor:
Anna Ronowska, Andrzej Szutowicz, Hanna Bielarczyk, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Agnieszka Jankowska-Kulawy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of
Externí odkaz:
https://doaj.org/article/6ab28e4ada614c72940a51303627420d
Autor:
Marlena Zyśk, Beata Gapys, Anna Ronowska, Sylwia Gul-Hinc, Anna Erlandsson, Adam Iwanicki, Monika Sakowicz-Burkiewicz, Andrzej Szutowicz, Hanna Bielarczyk
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209363 (2018)
One of the pathological site effects in excitotoxic activation is Zn2+ overload to postsynaptic neurons. Such an effect is considered to be equivalent to the glutamate component of excitotoxicity. Excessive uptake of Zn2+ by active voltage-dependent
Externí odkaz:
https://doaj.org/article/0e60551ccf7c486cb3c75f43ac5fb89f
Autor:
Anna Ronowska, Beata Gapys, S. Gul-Hinc, Anna Michno, Agnieszka Jankowska-Kulawy, Andrzej Szutowicz, Marlena Zyśk, Hanna Bielarczyk, D Bizon-Zygmanska
Publikováno v:
Nutritional Neuroscience. 24:432-442
Objectives: Zinc excitotoxicity and thiamine pyrophosphate deficiency (TD) are known pathogenic signals contributing to mechanism of different encephalopathies through inhibition of enzymes respons...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6a393e9c67da0ea025ee6aa97341c5
https://doi.org/10.1080/1028415x.2019.1641296
https://doi.org/10.1080/1028415x.2019.1641296
Publikováno v:
Pharmacological reports : PR. 72(1)
Hyperactivation of blood platelets is an essential factor in the pathomechanism of diabetes-evoked angiopathies. The aim of this work was to investigate whether blood platelets hyperactivation resulting from type 2 diabetic hyperglycaemia-increased p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468f587b0321a3e9f4f7d03882cb655
https://pubmed.ncbi.nlm.nih.gov/32016856
https://pubmed.ncbi.nlm.nih.gov/32016856
Autor:
Martyna Wesserling, Tadeusz Pawelczyk, Hanna Bielarczyk, Tomasz Przybyła, Izabela Maciejewska, Monika Sakowicz-Burkiewicz
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 78:268-278
The 5-fluorouracil (5FU)-based adjuvant chemotherapy improves the survival of patients with colorectal cancer, however the main obstacle affecting its effectiveness is a drug resistance. Our study aimed to investigate the impact of TWIST1 silencing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4161092f6845161f8b8bd778a31adef
https://doi.org/10.1016/j.biocel.2016.07.024
https://doi.org/10.1016/j.biocel.2016.07.024
Autor:
Hanna Bielarczyk, S. Gul-Hinc, Anna Ronowska, Andrzej Szutowicz, Aleksandra Dyś, Joanna Klimaszewska-Łata, Marlena Zyśk, Agnieszka Jankowska-Kulawy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7156344003483b5b0aa660da08ac24ac
https://www.frontiersin.org/article/10.3389/fncel.2018.00169/full
https://www.frontiersin.org/article/10.3389/fncel.2018.00169/full
Autor:
Beata Gapys, Adam Iwanicki, Anna Erlandsson, Andrzej Szutowicz, Anna Ronowska, Monika Sakowicz-Burkiewicz, S. Gul-Hinc, Hanna Bielarczyk, Marlena Zyśk
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209363 (2018)
PLoS ONE, Vol 13, Iss 12, p e0209363 (2018)
One of the pathological site effects in excitotoxic activation is Zn2+ overload to postsynaptic neurons. Such an effect is considered to be equivalent to the glutamate component of excitotoxicity. Excessive uptake of Zn2+ by active voltage-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be47bf26f7e008e58b2f0ce4b20abca
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373231
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373231
Autor:
S. Gul-Hinc, Tadeusz Pawelczyk, Corinna Höfling, Hanna Bielarczyk, Anna Ronowska, Reinhard Schliebs, Agnieszka Jankowska-Kulawy, Steffen Roßner, Andrzej Szutowicz
Publikováno v:
Journal of Alzheimer's Disease. 48:1083-1094
The pyruvate-derived acetyl-CoA is a principal direct precursor substrate for bulk energy synthesis in the brain. Deficits of pyruvate dehydrogenase in the neocortex are common features of Alzheimer's disease and other age-related encephalopathies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96978d7f3fb904282afc0e1686d8b388
https://doi.org/10.3233/jad-150327
https://doi.org/10.3233/jad-150327
Autor:
S. Gul-Hinc, Aleksandra Dyś, Marlena Zyśk, Anna Ronowska, Andrzej Szutowicz, Beata Gapys, Monika Sakowicz-Burkiewicz, Hanna Bielarczyk
Publikováno v:
Journal of Alzheimer's disease : JAD. 56(3)
Pyruvate dehydrogenase reaction utilizing glucose-derived pyruvate is an almost exclusive source of acetyl-CoA in different cell mitochondrial compartments of the brain. In neuronal mitochondria, the largest fraction of acetyl-CoA is utilized for ene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2693ec3be5b0653246e3d6b08edd2bb3
https://pubmed.ncbi.nlm.nih.gov/28106547
https://pubmed.ncbi.nlm.nih.gov/28106547
Autor:
Tadeusz Pawelczyk, Aleksandra Dyś, Andrzej Szutowicz, Marlena Zyśk, Hanna Bielarczyk, S. Gul-Hinc, Anna Ronowska, Joanna Klimaszewska-Łata
Publikováno v:
Biochemical Society Transactions. 42:1101-1106
Intramitochondrial decarboxylation of glucose-derived pyruvate by PDHC (pyruvate dehydrogenase complex) is a principal source of acetyl-CoA, for mitochondrial energy production and cytoplasmic synthetic pathways in all types of brain cells. The inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca2dc93b842e52da16c95a23038511
https://doi.org/10.1042/bst20140078
https://doi.org/10.1042/bst20140078