Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hanna Baltrukevich"'
Autor:
Hanna Baltrukevich, Piia Bartos
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Molecular dynamic (MD) simulations offer a way to study biomolecular interactions and their dynamics at the atomistic level. There are only a few studies of RNA-protein complexes in MD simulations, and here we wanted to study how force fields differ
Externí odkaz:
https://doaj.org/article/904fa91595594b3c98a8823f074a1ea5
Autor:
Hanna Baltrukevich, Sabina Podlewska
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
An increasing number of crystal structures available on one side, and the boost of computational power available for computer-aided drug design tasks on the other, have caused that the structure-based drug design tools are intensively used in the dru
Externí odkaz:
https://doaj.org/article/236943a9fa784c808922900c4b35c122
Autor:
Leonardo Brunetti, Rosalba Leuci, Antonio Carrieri, Marco Catto, Sara Occhineri, Giuseppe Vinci, Lucia Gambacorta, Hanna Baltrukevich, Sílvia Chaves, Antonio Laghezza, Cosimo Damiano Altomare, Paolo Tortorella, M. Amélia Santos, Fulvio Loiodice, Luca Piemontese
Publikováno v:
European journal of medicinal chemistry. 237
Alzheimer's disease (AD) is a widespread multifactorial aging-related pathology, which includes cholinergic deficit among its main causes. Following a multi-target design strategy, the structure of the approved drug donepezil was taken as the startin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a7486c2f3d7b58276ae7b5cf08488b
https://pubmed.ncbi.nlm.nih.gov/35462163
https://pubmed.ncbi.nlm.nih.gov/35462163
Autor:
Dorota Stary, Marharyta Barbasevich, Jędrzej Kukułowicz, Izabella Góral, Marek Bajda, Hanna Baltrukevich, Justyna Godyń
Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd4540dc682851481ed93e8dee3b5c2
https://ruj.uj.edu.pl/xmlui/handle/item/283281
https://ruj.uj.edu.pl/xmlui/handle/item/283281
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 49:128275
Despite the better understanding of the mechanisms underlying Alzheimer’s Disease (AD) and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been introduced for almost twenty years. The serotonin 5-HT6 and 5-HT7 rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa2be80ae45788451794bd875d00118
https://doi.org/10.1016/j.bmcl.2021.128275
https://doi.org/10.1016/j.bmcl.2021.128275