Improved predictions of total kidney volume growth rate in ADPKD using two-parameter least squares fitting

Autor: Zhongxiu Hu, Arman Sharbatdaran, Xinzi He, Chenglin Zhu, Jon D. Blumenfeld, Hanna Rennert, Zhengmao Zhang, Andrew Ramnauth, Daniil Shimonov, James M. Chevalier, Martin R. Prince

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Mayo Imaging Classification (MIC) for predicting future kidney growth in autosomal dominant polycystic kidney disease (ADPKD) patients is calculated from a single MRI/CT scan assuming exponential kidney volume growth and height-adjusted tota

Externí odkaz: https://doaj.org/article/5fadd57d8e8d41c3b65c55f7b50f6466

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Autor: Daniel Butler, Christopher Mozsary, Cem Meydan, Jonathan Foox, Joel Rosiene, Alon Shaiber, David Danko, Ebrahim Afshinnekoo, Matthew MacKay, Fritz J. Sedlazeck, Nikolay A. Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, Vijendra Ramlall, Evan T. Sholle, Edward J. Schenck, Craig D. Westover, Ciaran Hassan, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Dianna L. Ng, Andrea C. Granados, Yale A. Santos, Venice Servellita, Scot Federman, Phyllis Ruggiero, Arkarachai Fungtammasan, Chen-Shan Chin, Nathaniel M. Pearson, Bradley W. Langhorst, Nathan A. Tanner, Youngmi Kim, Jason W. Reeves, Tyler D. Hether, Sarah E. Warren, Michael Bailey, Justyna Gawrys, Dmitry Meleshko, Dong Xu, Mara Couto-Rodriguez, Dorottya Nagy-Szakal, Joseph Barrows, Heather Wells, Niamh B. O’Hara, Jeffrey A. Rosenfeld, Ying Chen, Peter A. D. Steel, Amos J. Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Angelika Iftner, Daniela Bezdan, Elizabeth Sanchez, Thomas R. Campion, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari M. Melnick, Sagi Shapira, Iman Hajirasouliha, Alain Borczuk, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars F. Westblade, Melissa Cushing, Shixiu Wu, Shawn Levy, Charles Chiu, Robert E. Schwartz, Nicholas Tatonetti, Hanna Rennert, Marcin Imielinski, Christopher E. Mason

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Here, using clinical samples and autopsy tissues, the authors combine fast-colorimetric test (LAMP) for SARS-CoV-2 infection and large-scale shotgun metatranscriptomics for host, viral, and microbial profiling and provide a map of the viral genetic f

Externí odkaz: https://doaj.org/article/e049d27579f84e2b9f12b7b11bc7c436

Next-Generation Sequencing of Cell-Free DNA Extracted From Pleural Effusion Supernatant: Applications and Challenges

Autor: Ami Patel, Erika Hissong, Lucelina Rosado, Robert Burkhardt, Lin Cong, Susan A. Alperstein, Momin T. Siddiqui, Hyeon Jin Park, Wei Song, Priya D. Velu, Hanna Rennert, Jonas J. Heymann

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Cell-free DNA (cfDNA) extracted from diverse specimen types has emerged as a high quality substrate for molecular tumor profiling. Analytical and pre-analytical challenges in the utilization of cfDNA extracted from pleural effusion supernatant (PES)

Externí odkaz: https://doaj.org/article/3b4a84d7a57a4e81bbd153f328da6866

Pleural Effusions on MRI in Autosomal Dominant Polycystic Kidney Disease

Autor: Jin Liu, Xiaorui Yin, Hreedi Dev, Xianfu Luo, Jon D. Blumenfeld, Hanna Rennert, Martin R. Prince

Publikováno v: Journal of Clinical Medicine; Volume 12; Issue 1; Pages: 386

Autosomal dominant polycystic kidney disease (ADPKD) has cystic fluid accumulations in the kidneys, liver, pancreas, arachnoid spaces as well as non-cystic fluid accumulations including pericardial effusions, dural ectasia and free fluid in the male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c085265094d93a6c79542800f8653b43

Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing

Autor: Hanna Rennert, Brian D. Robinson, Adrian Y. Tan, Jon D. Blumenfeld, Ines Chicos, Steven P. Salvatore, Hanwen Bai, Sandip Kapur, Stavros Giannakopoulos, Lior Rennert, Martin R. Prince, Zhengmao Zhang, Irina Barash, Alber Michaeel, Andrew B. Ramnauth, Karen Larbi, Genyan Liu, Stuart W. Hughes

Publikováno v: J Am Soc Nephrol

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development of multiple cysts in the kidneys. It is often caused by pathogenic mutations in PKD1 and PKD2 genes that encode polycystin protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534d73252ff87a211cfa17ae0df7cae3
https://doi.org/10.1681/asn.2021050690