Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Hanna, Osinska"'
Autor:
Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Manikandan Panchatcharam, Mohammad Alfrad Nobel Bhuiyan, Jonette M. Peretik, A. Wayne Orr, Jeanne James, Hanna Osinska, Jeffrey Robbins, John N. Lorenz, Md. Shenuarin Bhuiyan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. The presence of Sigmar1 in the heart was first reported on the basis of a ligand‐binding assay, and all studies to dat
Externí odkaz:
https://doaj.org/article/1dd8251c10164d81867abd304170e195
Autor:
Bidur Bhandary, Qinghang Meng, Jeanne James, Hanna Osinska, James Gulick, Iñigo Valiente‐Alandi, Michelle A. Sargent, Md. Shenuarin Bhuiyan, Burns C. Blaxall, Jeffery D. Molkentin, Jeffrey Robbins
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background Transforming growth factor beta (TGF‐β) is an important cytokine in mediating the cardiac fibrosis that often accompanies pathogenic cardiac remodeling. Cardiomyocyte‐specific expression of a mutant αB‐crystallin (CryABR120G), whic
Externí odkaz:
https://doaj.org/article/761a4cb3cf4649d4b6dd4661f7d03ab3
Autor:
Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Na Xu, Kritton Shay‐Winkler, James Gulick, Monte S. Willis, Cynthia Lander, Jeffrey Robbins
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 9 (2017)
BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C. Cardiac stress, as well as cMyBP‐C mutations, can trigger production of 1 such truncated prote
Externí odkaz:
https://doaj.org/article/dbc27fe9e550438e858ae6824cb461f1
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundCompromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology
Externí odkaz:
https://doaj.org/article/42995bb0396b4dfc8cd4ac5ad236510e
Autor:
Erda Alizoti, Lysa Michler, Ellen Orthey, Hanna Osinska, James Gulick, Birgit Klampe, Thomas Schulze, Arne Hansen, Saskia Schlossarek, Lucy Carrier, Patrick McLendon, Jeffrey Robbins, Sonia Singh
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:95-96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee62e454392cc891991cd5560ddacbaf
https://doi.org/10.1016/j.yjmcc.2022.08.193
https://doi.org/10.1016/j.yjmcc.2022.08.193
Autor:
Charu Munjal, Amy M. Opoka, Hanna Osinska, Jeanne F. James, Giorgio M. Bressan, Robert B. Hinton
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 8, Pp 987-996 (2014)
Aortic valve disease (AVD) is characterized by elastic fiber fragmentation (EFF), fibrosis and aberrant angiogenesis. Emilin1 is an elastin-binding glycoprotein that regulates elastogenesis and inhibits TGF-β signaling, but the role of Emilin1 in va
Externí odkaz:
https://doaj.org/article/81979e938a6f42e5b346f89f794ccbd3
Autor:
Erik N. Taylor, Matthew P. Hoffman, David Y. Barefield, George E. Aninwene, Aurash D. Abrishamchi, Thomas L. Lynch, Suresh Govindan, Hanna Osinska, Jeffrey Robbins, Sakthivel Sadayappan, Richard J. Gilbert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 3 (2016)
BackgroundThe geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein‐C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates m
Externí odkaz:
https://doaj.org/article/5f72b51f039a432d98e715f1d4b79367
Autor:
Naritaka Kimura, Hanna Osinska, R. Scott Baker, David L.S. Morales, Timothy K. Knilans, Michael D. Taylor, Jeffrey Robbins, Farhan Zafar
Publikováno v:
ASAIO Journal. 65:744-752
Lack of an ideal patch material for cardiac repairs continues to challenge congenital heart surgeons. The current materials are unable to grow and result in scarring, contraction, and arrhythmias. An acellular extracellular matrix (ECM) patch derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefd8db10ee7d51c02214081817a95b2
https://doi.org/10.1097/mat.0000000000000864
https://doi.org/10.1097/mat.0000000000000864
Autor:
Hanna Osinska, Ellen Orthey, Jeffery D. Molkentin, Saskia Schlossarek, Jeffrey Robbins, Erda Alizoti, Sonia R. Singh, James Gulick, W. Clark Bacon, Moritz Meyer-Jens, Lucie Carrier, Gregory Davis, Silke Reischmann-Düsener, Patrick M. McLendon
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway (ALP) are two major protein degradation pathways in eukaryotic cells. Initially considered as two independent pathways, there is emerging evidence that they can work in concert. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2616168058768ad85f2eec8958db534
https://pubmed.ncbi.nlm.nih.gov/33249983
https://pubmed.ncbi.nlm.nih.gov/33249983
Autor:
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 2 (2013)
A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Ba
Externí odkaz:
https://doaj.org/article/05dd5d4356784fc28183de961bc98086