Výsledky vyhledávání - "Hanmant K. Gaikwad"

Molecular basis of conformational changes and mechanics of integrins

Autor: Hanmant K. Gaikwad, Sharad V. Jaswandkar, Kalpana S. Katti, Amanda Haage, Dinesh R. Katti

Publikováno v: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 381

Integrin, as a mechanotransducer, establishes the mechanical reciprocity between the extracellular matrix (ECM) and cells at integrin-mediated adhesion sites. This study used steered molecular dynamics (SMD) simulations to investigate the mechanical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f154ead8b1d2d18b0152b0e64596d6
https://doi.org/10.1098/rsta.2022.0243

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Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells

Autor: M. Janaki Ramaiah, Lingaiah Nagarapu, G. Narahari Sastry, Ramineni Venkatesh, Manika-Pal Bhadra, A. Raksha Ganesh, Hanmant K. Gaikwad, Sridhara Janardhan, Rajashaker Bantu

Publikováno v: European Journal of Medicinal Chemistry. 94:87-101

A series of novel quinazolinone hybrids were synthesized by employing click chemistry and evaluated for anti-proliferative activities against MCF-7, HeLa and K562 cell lines. Among these cell lines, HeLa cells were found to respond effectively to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d1ab6a6eca8dc9685c24802a0edb18
https://doi.org/10.1016/j.ejmech.2015.02.057

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Convenient Approach for the One-Pot, Three-Component Synthesis of Triheterocyclic 4H-Pyrimido[2,1-b]benzothiazole Derivatives Using TBAHS

Autor: Lingaiah Nagarapu, Jyothsna Devi Palem, B. Sridhar, Rajashaker Bantu, Hanmant K. Gaikwad, Ramineni Venkatesh

Publikováno v: Synthetic Communications. 43:93-104

An efficient and convenient synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives has been achieved by a one-pot, three-component condensation reaction of 2-aminobenzothiazole (1) with substituted benzaldehydes (2a–f) and β-dicarbonyl derivativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be8c19ceb61fe44bc7ca733d86c8d858
https://doi.org/10.1080/00397911.2011.592624

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TBAHS-Catalyzed Synthesis of 2-Dihydroquinazolin-2-ylquinoline: An Efficient and Practical Synthesis of Naturally Occurring Alkaloids Luotonin A, B, and E

Autor: Hanmant K. Gaikwad, Lingaiah Nagarapu, Rajashaker Bantu

Publikováno v: Synlett. 23:1775-1778

A synthesis of 2-dihydroquinazolin-2-ylquinoline using a phase-transfer catalyst (TBAHS) in semi-aqueous phase, followed by Mitsunobu cyclization as key steps for an efficient and practical synthesis of naturally occurring alkaloids luotonin A, B, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed0481a821c3c6e67f4686f0533ef6b
https://doi.org/10.1055/s-0032-1316537

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Synthesis of novel building blocks of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one and evaluation of their antitumor activity

Autor: Hanmant K. Gaikwad, Shasi V. Kalivendi, Sheeba Rani Manikonda, Krishna Madhuri Manda, Rajashaker Bantu, Lingaiah Nagarapua

Publikováno v: Medicinal Chemistry Research. 22:165-174

A series of new building blocks consisting of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one with potential as selective antitumor agents is described. Compounds were synthesized by using Heck reaction of N-allyl-1H-pyrrolo[3,4-b]quinolin-3(2H)-one with p-bromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a096145d35e2e514fe59761e3ff8c993
https://doi.org/10.1007/s00044-012-0018-x

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Lewis acid-assisted olefin cross-metathesis reaction: an efficient approach for the synthesis of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin and evaluation of their antitumor activity

Autor: Hanmant K. Gaikwad, Lingaiah Nagarapu, Rajashaker Bantu, C. Ganesh Kumar, Sujitha Pombala, Sheeba Rani Manikonda

Publikováno v: Tetrahedron Letters. 53:1287-1291

A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin ( 2a – g ) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti(O i Pr) 4 30 mol % and 10 mol % of Grubb’s second generation catal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c62ec1abc4509f99ab1d92bbc7da4ab9
https://doi.org/10.1016/j.tetlet.2012.01.001

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Design and synthesis of 3-(3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)-2-phenylquinazolin-4(3H)-one derivatives to induce ACE inhibitory activity

Autor: Sridhara Janardhan, Lingaiah Nagarapu, Rajashaker Bantu, G. Narahari Sastry, Suresh Kasaboina, Ramineni Venkatesh, Sanjay K. Banerjee, Hanmant K. Gaikwad

Publikováno v: European journal of medicinal chemistry. 96

In an attempt to develop a new class of cardiovascular drugs, a series of novel carbazolyloxy phenylquinazoline derivatives 9a – g have been synthesized and evaluated as angiotensin converting enzyme (ACE) inhibitors. Most of these compounds exhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a99039bb9c47ee3bc596b22d169475
https://pubmed.ncbi.nlm.nih.gov/25874328

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