Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hanlun, Jiang"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Lizhe Zhu et al. use a quasi Markov State Model built from extensive molecular dynamics simulations to elucidate the dynamics of RISC-mRNA interactions. Their results provide further insight on how a target nucleotide is positioned before recognition
Externí odkaz:
https://doaj.org/article/f9b08be56b81469197c788250c9a00d7
Autor:
Jordy Homing Lam, Yu Li, Lizhe Zhu, Ramzan Umarov, Hanlun Jiang, Amélie Héliou, Fu Kit Sheong, Tianyun Liu, Yongkang Long, Yunfei Li, Liang Fang, Russ B. Altman, Wei Chen, Xuhui Huang, Xin Gao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Interactions between proteins and RNA are an important mechanism for post-transcriptional regulation, but predicting these interactions is difficult. Through a deep learning approach, here the authors predict RNA-binding sites and binding preference
Externí odkaz:
https://doaj.org/article/361a2a5e8af64738999759aa8027bf6e
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 7, p e1004404 (2015)
Argonaute (Ago) proteins and microRNAs (miRNAs) are central components in RNA interference, which is a key cellular mechanism for sequence-specific gene silencing. Despite intensive studies, molecular mechanisms of how Ago recognizes miRNA remain lar
Externí odkaz:
https://doaj.org/article/d6891f67164848be9b743bf0a01f5afd
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Despite its functional importance, the molecular mechanism underlying target mRNA recognition by Argonaute (Ago) remains largely elusive. Based on extensive all-atom molecular dynamics simulations, we constructed quasi-Markov State Model (qMSM) to re
Autor:
Lizhe Zhu, Fu Kit Sheong, Xin Gao, Tianyun Liu, Hanlun Jiang, Yunfei Li, Jordy Homing Lam, Wei Chen, Yongkang Long, Liang Fang, Amélie Héliou, Ramzan Umarov, Yu Li, Russ B. Altman, Xuhui Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Protein-RNA interaction plays important roles in post-transcriptional regulation. However, the task of predicting these interactions given a protein structure is difficult. Here we show that, by leveraging a deep learning model NucleicNet, attributes
Publikováno v:
Progress in Biophysics and Molecular Biology. 128:39-46
At the core of RNA interference, the Argonaute proteins (Ago) load and utilize small guide nucleic acids to silence mRNAs or cleave foreign nucleic acids in a sequence specific manner. In recent years, based on extensive structural studies of Ago and
Publikováno v:
Molecular cell. 67(2)
A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since it
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1517
MicroRNA (miRNA) and Argonaute (AGO) protein together form the RNA-induced silencing complex (RISC) that plays an essential role in the regulation of gene expression. Elucidating the underlying mechanism of AGO-miRNA recognition is thus of great impo
Publikováno v:
Drug Target miRNA: Methods and Protocols
Drug Target miRNA: Methods and Protocols, pp.251--275, 2016, 978-1-4939-6563-2. ⟨10.1007/978-1-4939-6563-2_18⟩
Methods in Molecular Biology ISBN: 9781493965618
Drug Target miRNA: Methods and Protocols, pp.251--275, 2016, 978-1-4939-6563-2. ⟨10.1007/978-1-4939-6563-2_18⟩
Methods in Molecular Biology ISBN: 9781493965618
International audience; MicroRNA (miRNA) and Argonaute (AGO) protein together form the RNA-induced silencing complex (RISC) that plays an essential role in the regulation of gene expression. Elucidating the underlying mechanism of AGO-miRNA recogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d511958f87f492620dc0e5dafa7f01d
https://inria.hal.science/hal-01569854
https://inria.hal.science/hal-01569854
Publikováno v:
The journal of physical chemistry. B. 120(10)
Argonaute proteins (Ago) are core components of the RNA Induced Silencing Complex (RISC) that load and utilize small guide nucleic acids to silence mRNAs or cleave foreign DNAs. Despite the essential role of Ago in gene regulation and defense against