Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hanlan Liu"'
Autor:
Phillip Spinosa, Monika Musial‐Siwek, Marc Presler, Alison Betts, Emily Rosentrater, Janice Villali, Lucia Wille, Yang Zhao, Tom McCaughtry, Kalyanasundaram Subramanian, Hanlan Liu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 220-229 (2021)
Abstract A semimechanistic pharmacokinetic (PK)/receptor occupancy (RO) model was constructed to differentiate a next generation anti‐NKG2A monoclonal antibody (KSQ mAb) from monalizumab, an immune checkpoint inhibitor in multiple clinical trials f
Externí odkaz:
https://doaj.org/article/bd9464c4303343c293117281a5906710
Autor:
Kefei Zheng, Allena Ji, Lee Lee Chung, Kerry Culm-Merdek, Hanlan Liu, Susan Richards, Crystal Sung
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 8, Iss C, Pp 77-79 (2016)
Glucosylceramide (GL-1) level in human has been considered as a surrogate biomarker for enzyme replacement and substrate reduction therapies (ERT and SRT) for Gaucher and Fabry patients. Due to the high endogenous level of GL-1 in human plasma, it is
Externí odkaz:
https://doaj.org/article/d9151cf14319471e97da8f61841a78e4
Publikováno v:
Drug Metabolism Letters. 14:41-53
Background: Carbon-carbon bond cleavage of a saturated aliphatic moiety is rarely seen in xenobiotic metabolism. Olanexidine (Olanedine®), containing an n-octyl (C8) side chain, was mainly metabolized to various shortened side chain (C4to C6) acid-c
Autor:
Tom McCaughtry, Emily Rosentrater, Monika Musial-Siwek, Marc Presler, Hanlan Liu, Janice Villali, Phillip Spinosa, Yang Zhao, Kalyanasundaram Subramanian, Alison Betts, Lucia Wille
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 220-229 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
A semimechanistic pharmacokinetic (PK)/receptor occupancy (RO) model was constructed to differentiate a next generation anti‐NKG2A monoclonal antibody (KSQ mAb) from monalizumab, an immune checkpoint inhibitor in multiple clinical trials for the tr
Publikováno v:
Journal of Mass Spectrometry. 54:158-166
Reactive metabolites are thought to play a pivotal role in the pathogenesis of some drug-induced liver injury (DILI) and idiosyncratic adverse drug reactions (IADRs), which is of concern to patient safety and has been a cause of drugs being withdrawn
Autor:
Gihan Tennekoon, A. Nichols, Sabrina W. Yum, Hanlan Liu, P. Bista, Angelika Fretzen, Erika Finanger, H. Lee Sweeney, Richard S. Finkel, Krista Vandenborne, Joanne M. Donovan, Maria Cecilia Mancini
Publikováno v:
Journal of Neuromuscular Diseases
Background: Edasalonexent is an orally administered small molecule designed to inhibit NF-κB, which is activated from infancy in Duchenne muscular dystrophy and is central to causing muscle damage and preventing muscle regeneration. Objective: Evalu
Autor:
Louise Cadzow, Erica Tobin, Pamela Sullivan, Sol Shenker, Sumeet Nayak, Janid Ali, Hugh Gannon, Anne Dodson, Paula Grasberger, Alyssa Carlson, Michael McGuire, Jehrod Brenneman, Hanlan Liu, Andrew Olaharski, Kerstin Sinkevicius, Jeff Hixon, Elsa Krall, Mike Schlabach, Matt Goulet, Jeremy Wilt, Patricia Harris, Frank Stegmeier, Andrew Wylie
Publikováno v:
Cancer Research. 82:ND01-ND01
Tumors with BRCA1/2 mutations and other homologous repair deficiencies (HRD) are vulnerable to agents that target the remaining DNA repair pathways, including platinum-containing chemotherapy agents and molecules targeting poly (ADP-ribose) polymeras
Publikováno v:
Drug metabolism reviews. 52(1)
Bioconjugation of therapeutic agents has been used as a selective drug delivery platform for many therapeutic areas. Bioconjugates are prepared by the covalent linkage of active compounds (small or large molecule) to a carrier molecule (lipids, prote
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 153:267-273
An ultra-high pressure liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was successfully developed and qualified for the simultaneous determination of triamcinolone hexacetonide (TAH) and triamcinolone acetonide (TAA, the active
Autor:
Laura Coppola, Emma Whale, Chad Briscoe, Eric Yang, Jeff Duggan, Ragu Ramanathan, Stephen Vinter, Rafiq Islam, Mark E. Arnold, Rand Jenkins, Akiko Ishii-Watabe, Brad Ackermann, Gustavo Mendes Lima Santos, Nicola Hughes, Daniela Fraier, Adrien Musuku, Hanlan Liu, Scott G. Summerfield, Lucinda Hittle, Sean Kassim, Rachel Green, Sam Haidar, Sekhar Surapaneni, Yoshiro Saito, Mark Bustard, Nilufer Tampal, Olga Kavetska, Jens Sydor, Stephen C. Alley, John T Mehl, Tom Verhaeghe, Brian Rago, Michael H. Buonarati, Olivier Le Blaye, Wenkui Li, Isabella Berger, Mark Cancilla, Eric Woolf, Matthew Szapacs, Seongeun Julia Cho, Natasha Savoie, John Kadavil, Fabio Garofolo, Barry R Jones, Anita Lee, Jan Welink
Publikováno v:
Bioanalysis. 9(22)
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies