Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Hanke L"'
Autor:
Panagiota Bouti, Bart J. A. M. Klein, Paul J. H. Verkuijlen, Karin Schornagel, Floris P. J. van Alphen, Kees-Karel H. Taris, Maartje van den Biggelaar, Arie J. Hoogendijk, Robin van Bruggen, Taco W. Kuijpers, Hanke L. Matlung
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orches
Externí odkaz:
https://doaj.org/article/53bd94c6190c4bc09c41a6251de19372
Autor:
Angela A. F. Gankema, Charita Furumaya, Sara Fernández-Hermira, Mark Hoogenboezem, Hanke L. Matlung, Robin van Bruggen, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer is one of the leading causes of death worldwide. Treatment outcome is largely dictated by the tumor type, disease stage, and treatment success rates, but also by the variation among patients in endogenous anti-tumor responses. Studies indicate
Externí odkaz:
https://doaj.org/article/a0094b75d97d41fcb931be4af775aa0c
Autor:
Timo K van den Berg, Hugo Olsman, Hanke L Matlung, Katka Franke, Imke Lodewijks, Lilian Driessen-Engels, Mary J van Helden, Seline A Zwarthoff, Roel J Arends, Inge M J Reinieren-Beeren, Marc C B C Paradé, Karin de Laat-Arts, Désirée Damming, Ellen W H Santegoeds-Lenssen, Daphne W J van Kuppeveld, Ellen Mattaar-Hepp, Marloes E M Stokman, Benny de Wit, Dirk H R F Glaudemans, Daniëlle E J W van Wijk, Lonnie Joosten-Stoffels, Jan Schouten, Paul J Boersema, Monique van der Vleuten, Jorien W H Sanderink, Wendela A Kappers, Diels van den Dobbelsteen, Marco Timmers, Ruud Ubink, Gerard J A Rouwendal, Gijs Verheijden, Miranda M C van der Lee, Wim H A Dokter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Preclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. Howev
Externí odkaz:
https://doaj.org/article/b070a5b304cf452fb3bfdad0492340e0
Autor:
Paula Martinez-Sanz, Adrien R. G. Laurent, Edith Slot, Mark Hoogenboezem, Nikolina Bąbała, Robin van Bruggen, Anthony Rongvaux, Richard A. Flavell, Godelieve A. M. Tytgat, Katka Franke, Hanke L. Matlung, Taco W. Kuijpers, Derk Amsen, Julien J. Karrich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMISTRG mice have been genetically modified to allow development of a human myeloid compartment from engrafted human CD34+ haemopoietic stem cells, making them particularly suited to study the human innate immune system in vivo. Here, we c
Externí odkaz:
https://doaj.org/article/6f2a3ef6081c4018ae68e848da1ea48c
Publikováno v:
Deutsche Zeitschrift für Sportmedizin, Vol 5, Iss 2022 (2022)
Problems: Hypothyroidism is associated with increased cardiovascular events and a reduced quality of life. The goal of this systematic review is to identify additive treatment strategies besides hormone replacement through diet and exercise intervent
Externí odkaz:
https://doaj.org/article/1b95c072f8ee40b0b2773885c69264ee
Autor:
Sung-Bae Kim, Taco W Kuijpers, Christos Sotiriou, Serena Di Cosimo, Jens Huober, Rebecca Roylance, Anton T J Tool, Dieke J van Rees, Bart Klein, Panagiota Bouti, Karin Schornagel, Robin van Bruggen, Hanke L Matlung, Paul J H Verkuijlen, Michel van Houdt, David Venet, Sarra El-Abed, Miguel Izquierdo, Sébastien Guillaume, Cristina Saura, Timo K van den Berg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/3d89e798eabc475db6aa7a70b1a6e87f
Autor:
Taco W Kuijpers, Timo K van den Berg, Paula Martinez Sanz, Dieke J van Rees, Lieke M J van Zogchel, Bart Klein, Panagiota Bouti, Hugo Olsman, Karin Schornagel, Ivana Kok, Ali Sunak, Kira Leeuwenburg, Ilse Timmerman, Miranda P Dierselhuis, Waleed M Kholosy, Jan J Molenaar, Robin van Bruggen, Hanke L Matlung, Godelieve A M Tytgat, Katka Franke
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background Current immunotherapy for patients with high-risk neuroblastoma involves the therapeutic antibody dinutuximab that targets GD2, a ganglioside expressed on the majority of neuroblastoma tumors. Opsonized tumor cells are killed through antib
Externí odkaz:
https://doaj.org/article/46fbc1b19e6b4747a8d3b3240b54b322
Autor:
Panagiota Bouti, Steven D. S. Webbers, Susanna C. Fagerholm, Ronen Alon, Markus Moser, Hanke L. Matlung, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the innate immune response against invading bacterial and fungal pathogens, while recent emerging evidence also demonstrates their role in cancer progression
Externí odkaz:
https://doaj.org/article/572fb513c6ea41069fe1f4be174f5cf2
Autor:
Annette E. Neele, Hung-Jen Chen, Marion J. J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C. S. Boshuizen, Jan Van den Bossche, Anton T. Tool, Hanke L. Matlung, Timo K. van den Berg, Esther Lutgens, Menno P. J. de Winther
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathways in macr
Externí odkaz:
https://doaj.org/article/a428a6da91984e6f8be4eb28adb8b03a
Autor:
Katka Franke, Saravanan Y. Pillai, Mark Hoogenboezem, Marion J. J. Gijbels, Hanke L. Matlung, Judy Geissler, Hugo Olsman, Chantal Pottgens, Patrick J. van Gorp, Maria Ozsvar-Kozma, Yasuyuki Saito, Takashi Matozaki, Taco W. Kuijpers, Rudi W. Hendriks, Georg Kraal, Christoph J. Binder, Menno P. J. de Winther, Timo K. van den Berg
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The inhibitory immunoreceptor SIRPα is expressed on myeloid and neuronal cells and interacts with the broadly expressed CD47. CD47-SIRPα interactions form an innate immune checkpoint and its targeting has shown promising results in cancer patients.
Externí odkaz:
https://doaj.org/article/ee6a819bfd8145e18c05d69a81a9717a