Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools.

Autor: Hank EC; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany., Sai M; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany., Kasch T; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany., Meijer I; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany., Marschner JA; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany., Merk D; Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16598-16611. Date of Electronic Publication: 2024 Sep 05.

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Autor: Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Benítez-Buelga C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), 28029 Madrid, Spain., Calvo PA; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain., Hanna BMF; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Masuyer G; Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, UK.; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden., Davies J; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden., Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Albers JJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Castañeda-Zegarra S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491 Trondheim, Norway., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Visnes T; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway., Sastre-Perona A; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain., Danda AN; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Marimuthu K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Zhenjun Z; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Chi CN; Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden., Sarno A; Department of Environment and New Resources, SINTEF Ocean, N-7496 Trondheim, Norway., Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., von Nicolai C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Komor AJ; Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Department of Biomolecular Chemistry, 07745 Jena, Germany., Rajagopal V; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Müller S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Hank EC; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Varga M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Scaletti ER; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Pandey M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK., Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Haslene-Hox H; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway., Loevenich S; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway., Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Mamonov K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Ortis F; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Schömberg F; Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany., Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Stewart J; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., D'Arcy-Evans N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Michel D; Chemical Processes and Pharmaceutical Development, Unit Process Chemistry I, Research Institutes of Sweden - RISE, 151 36 Södertälje, Sweden., de Ory A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden., Acero L; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain., Calvete O; Familial Cancer Clinical Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain., Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Hertweck C; Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Department of Biomolecular Chemistry, 07745 Jena, Germany.; Institute of Microbiology, Friedrich-Schiller-University Jena, 07743 Jena, Germany., Vilotijevic I; Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., Osorio A; Familial Cancer Clinical Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain., Perona R; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain., Stolz A; Institute of Biochemistry II and Buchmann Institute for Molecular Life Science, Goethe University Frankfurt, 60590 Frankfurt, Germany., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden., de Vega M; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Jun 24; Vol. 376 (6600), pp. 1471-1476. Date of Electronic Publication: 2022 Jun 23.