Zobrazeno 1 - 10
of 527
pro vyhledávání: '"Hanjoong, Jo"'
Autor:
Yutong Guo, Hohyun Lee, Chulyong Kim, Christian Park, Akane Yamamichi, Pavlina Chuntova, Marco Gallus, Miguel O. Bernabeu, Hideho Okada, Hanjoong Jo, Costas Arvanitis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Microbubble-enhanced ultrasound provides a noninvasive physical method to locally overcome major obstacles to the accumulation of blood-borne therapeutics in the brain, posed by the blood-brain barrier (BBB). However, due to the highly nonli
Externí odkaz:
https://doaj.org/article/c4c8720a5c544fd09a3822eb2f6b69c6
Autor:
Parvin Forghani, Aysha Rashid, Lawrence C. Armand, David Wolfson, Rui Liu, Hee Cheol Cho, Joshua T. Maxwell, Hanjoong Jo, Khalid Salaita, Chunhui Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous potential for basic research and translational application. However, these cells structurally and functionally resemble fetal cardiomyocytes, whi
Externí odkaz:
https://doaj.org/article/3296641540fe46919673509caadadabf
Autor:
Ambra Cappelletto, Edoardo Alfì, Nina Volf, Thi Van Anh Vu, Francesca Bortolotti, Giulio Ciucci, Simone Vodret, Marco Fantuz, Martina Perin, Andrea Colliva, Giacomo Rozzi, Matilde Rossi, Giulia Ruozi, Lorena Zentilin, Roman Vuerich, Daniele Borin, Romano Lapasin, Silvano Piazza, Mattia Chiesa, Daniela Lorizio, Luca Triboli, Sandeep Kumar, Gaia Morello, Claudio Tripodo, Maurizio Pinamonti, Giulia Maria Piperno, Federica Benvenuti, Alessandra Rustighi, Hanjoong Jo, Stefano Piccolo, Giannino Del Sal, Alessandro Carrer, Mauro Giacca, Serena Zacchigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because they are identified by cellular or in silico screens that cannot predi
Externí odkaz:
https://doaj.org/article/a789156b8a0b44008d091dcfb970d332
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/33479fce00784d0aaa14e0a46239f0ff
Autor:
Leonardo Y. Tanaka, Sandeep Kumar, Lucas F. Gutierre, Celso Magnun, Daniela Kajihara, Dong-Won Kang, Francisco R. M. Laurindo, Hanjoong Jo
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Redox processes can modulate vascular pathophysiology. The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stre
Externí odkaz:
https://doaj.org/article/d94ab7f322dd461c80bc666ed3c3e66e
Autor:
Jing Echesabal-Chen, Kun Huang, Lucia Vojtech, Olanrewaju Oladosu, Ikechukwu Esobi, Rakesh Sachdeva, Naren Vyavahare, Hanjoong Jo, Alexis Stamatikos
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 5631-5644 (2023)
Atherosclerosis is driven by intimal arterial macrophages accumulating cholesterol. Atherosclerosis also predominantly occurs in areas consisting of proinflammatory arterial endothelial cells. At time of writing, there are no available clinical treat
Externí odkaz:
https://doaj.org/article/bb3d25a7fdfb4fa396d4c1a0868bcf53
Autor:
Sean M. Carr, PhD, Katherine Owsiany, MD, PhD, Ottis Scrivner, PhD, Dylan McLaughlin, MD, Hanjoong Jo, PhD, Luke P. Brewster, Katherine E. Hekman, MD, PhD
Publikováno v:
JVS - Vascular Science, Vol 5, Iss , Pp 100193- (2024)
Background: Induced pluripotent stem cells (iPSCs) directed to endothelial identity (iPSC-ECs) are emerging as a potent tool for regenerative medicine in vascular disease. However, iPSC-ECs lose expression of key identity markers under standard in vi
Externí odkaz:
https://doaj.org/article/64bb1a5600c84eac8dd7e571d75bdc88
Autor:
Dong Hoon Kang, Yerin Kim, Seongchun Min, Su Youn Lee, Ka Young Chung, In-Jeoung Baek, Kihwan Kwon, Hanjoong Jo, Sang Won Kang
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113361- (2023)
Summary: Vascular endothelial growth factor receptor-2 (VEGFR2) plays a key role in maintaining vascular endothelial homeostasis. Here, we show that blood flows determine activation and inactivation of VEGFR2 through selective cysteine modifications.
Externí odkaz:
https://doaj.org/article/9b602d14b06f45a29435838d47121b5e
Autor:
Gloriani Sánchez Marrero, Nicolas Villa-Roel, Feifei Li, Christian Park, Dong-Won Kang, Katherine E. Hekman, Hanjoong Jo, Luke P. Brewster
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The mechanical environment of endothelial cells (ECs) in PAD is characteri
Externí odkaz:
https://doaj.org/article/61b2ee7740b748fc945a0bebbdf83520
Autor:
Yerin Kim, Namhee Yu, Ye Eun Jang, Eunkyung Lee, Yeonjoo Jung, Doo Jae Lee, W. Robert Taylor, Hanjoong Jo, Jaesang Kim, Sanghyuk Lee, Sang Won Kang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Endothelial dysfunction and inflammatory immune response trigger dedifferentiation of vascular smooth muscle cells (SMCs) from contractile to synthetic phenotype and initiate arterial occlusion. However, the complex vascular remodeling proce
Externí odkaz:
https://doaj.org/article/c77127ba599e4589abbe5b3faa047b1b