Clinically relevant thresholds for ultrasensitive HIV drug resistance testing: a multi-country nested case-control study

Autor: Sulaimon Akanmu, Akin Osibogun, Jack Menke, Titilope A Adeyemo, Miiro Mutebi, Ian Sanne, Cissy Kityo, Kim C. E. Sigaloff, Seth C Inzaule, Esrom Letsoalo, Miriam Nakitto, Margaret Siwale, Tope Rodoye, Cathy Nalubwama, H. Namata, Denise Naniche, Ritah Nakanjako, Mariette E. Botes, Pascale Ondoa, Wendy S. Stevens, Martin O'Mello, Ruedi Lüthy, Carole L. Wallis, Fred Senono, Marian Dolan, Hameed Adelabu, Immaculate Nankya, Mariona Parera, Hanipha Kakooza, Maria Casadellà, T. Sonia Boender, Roger Paredes, Raph L. Hamers, Margaret Hardman, Kishor Mandaliya, Tobias F. Rinke de Wit, Marc Noguera-Julian, Joep M. A. Lange, Marleen de Jager, Maureen Wellington, Kim Steegen, Nadine Pakker, Sheila Balinda, Bonaventura Clotet, Moheb Labib, Rob Schuurman, Prudence Ive, Winnie Namala, Peter Mugyenyi

Publikováno v: Lancet HIV, 5(11), e638-e646. Elsevier Limited
The Lancet HIV, 5(11), e638-e646. Elsevier Limited
PanAfrican Studies to Evaluate Resistance 2018, ' Clinically relevant thresholds for ultrasensitive HIV drug resistance testing : a multi-country nested case-control study ', The Lancet HIV, vol. 5, no. 11, pp. e638-e646 . https://doi.org/10.1016/S2352-3018(18)30177-2

BACKGROUND: Implementation of ultrasensitive HIV drug resistance tests for routine clinical use is hampered by uncertainty about the clinical relevance of drug-resistant minority variants. We assessed different detection thresholds for pretreatment d

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