Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Hanina, Hibshoosh"'
Autor:
Yifan Tai, Angela Chow, Seoyoung Han, Courtney Coker, Wanchao Ma, Yifan Gu, Valeria Estrada Navarro, Manoj Kandpal, Hanina Hibshoosh, Kevin Kalinsky, Katia Manova-Todorova, Anton Safonov, Elaine M Walsh, Mark Robson, Larry Norton, Richard Baer, Taha Merghoub, Anup K Biswas, Swarnali Acharyya
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1957-1980 (2024)
Abstract Acquired resistance to PARP inhibitors (PARPi) remains a treatment challenge for BRCA1/2-mutant breast cancer that drastically shortens patient survival. Although several resistance mechanisms have been identified, none have been successfull
Externí odkaz:
https://doaj.org/article/2b7acab7d8864163a88c5615d51c25ce
Autor:
Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi, Candace Castagna, Hui Tan, Miroslav Sekulic, Lisa Miorin, Hanina Hibshoosh, Shinya Toyokuni, Koji Uchida, Brent R. Stockwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependen
Externí odkaz:
https://doaj.org/article/527ab259b3444321abb3fec36082bca3
Autor:
Sungsoo Kim, Jessica Armand, Anton Safonov, Mimi Zhang, Rajesh K. Soni, Gary Schwartz, Julia E. McGuinness, Hanina Hibshoosh, Pedram Razavi, Minah Kim, Sarat Chandarlapaty, Hee Won Yang
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113198- (2023)
Summary: Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are key therapeutic agents in the management of metastatic hormone-receptor-positive breast cancer. However, the emergence of drug resistance limits their long-term efficacy. Here, we show
Externí odkaz:
https://doaj.org/article/ad5bf604ff2245b3b34e9324275ec4e4
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Kyrie Pappas, Tiphaine C. Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jin, Hanina Hibshoosh, Ramon Parsons
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Pappas et al. show that the combination of NOTCH and EZH2 alterations drive transcriptional repression of PTEN through reversible epigenetic modification of the PTEN promoter. These results suggest an actionable target for treating poor-prognosis bre
Externí odkaz:
https://doaj.org/article/0d639da6ef5d412789a11baff7e2a9fe
Autor:
Mirella L. Altoe, Kevin Kalinsky, Alessandro Marone, Hyun K. Kim, Hua Guo, Hanina Hibshoosh, Mariella Tejada, Katherine D. Crew, Melissa K. Accordino, Meghna S. Trivedi, Dawn L. Hershman, Andreas H. Hielscher
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-9 (2021)
Abstract Background The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients admini
Externí odkaz:
https://doaj.org/article/bee1ff9d1e73484ea3297e0ed97b8c5e
Autor:
Ahmad Rushdi Shakri, Timothy James Zhong, Wanchao Ma, Courtney Coker, Rohaan Hegde, Hanna Scholze, Vanessa Chin, Matthias Szabolcs, Hanina Hibshoosh, Kurenai Tanji, Richard Baer, Anup Kumar Biswas, Swarnali Acharyya
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6766-6775 (2020)
Abstract Nearly 80% of advanced cancer patients are afflicted with cachexia, a debilitating syndrome characterized by extensive loss of muscle mass and function. Cachectic cancer patients have a reduced tolerance to antineoplastic therapies and often
Externí odkaz:
https://doaj.org/article/21f364a05f8948c6935977c5eace599f
Autor:
Michael I. Brener, Michelle L. Hulke, Nobuaki Fukuma, Stephanie Golob, Robert S. Zilinyi, Zhipeng Zhou, Christos Tzimas, Ilaria Russo, Claire McGroder, Ryan D. Pfeiffer, Alexander Chong, Geping Zhang, Daniel Burkhoff, Martin B. Leon, Mathew S. Maurer, Jeffrey W. Moses, Anne-Catrin Uhlemann, Hanina Hibshoosh, Nir Uriel, Matthias J. Szabolcs, Björn Redfors, Charles C. Marboe, Matthew R. Baldwin, Nathan R. Tucker, Emily J. Tsai
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute cardiac injury is prevalent in critical COVID-19 and associated with increased mortality. Its etiology remains debated, as initially presumed causes — myocarditis and cardiac necrosis — have proved uncommon. To elucidate the pathophysiology
Externí odkaz:
https://doaj.org/article/2de2e76911bc473598fb90fee54b07f0
Autor:
Prabhjot S. Mundi, Filemon S. Dela Cruz, Adina Grunn, Daniel Diolaiti, Audrey Mauguen, Allison R. Rainey, Kristina Guillan, Armaan Siddiquee, Daoqi You, Ronald Realubit, Charles Karan, Michael V. Ortiz, Eugene F. Douglass, Melissa Accordino, Suzanne Mistretta, Frances Brogan, Jeffrey N. Bruce, Cristina I. Caescu, Richard D. Carvajal, Katherine D. Crew, Guarionex Decastro, Mark Heaney, Brian S. Henick, Dawn L. Hershman, June Y. Hou, Fabio M. Iwamoto, Joseph G. Jurcic, Ravi P. Kiran, Michael D. Kluger, Teri Kreisl, Nicole Lamanna, Andrew B. Lassman, Emerson A. Lim, Gulam A. Manji, Guy M. McKhann, James M. McKiernan, Alfred I. Neugut, Kenneth P. Olive, Todd Rosenblat, Gary K. Schwartz, Catherine A. Shu, Michael B. Sisti, Ana Tergas, Reena M. Vattakalam, Mary Welch, Sven Wenske, Jason D. Wright, Peter Canoll, Hanina Hibshoosh, Kevin Kalinsky, Mahalaxmi Aburi, Peter A. Sims, Mariano J. Alvarez, Andrew L. Kung, Andrea Califano
Publikováno v:
Cancer Discovery. :OF1-OF22
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies to predict tumor sensitivity to a comprehensive repertoire of clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2372be69c8c6242e5877bc9ce0d6bdc4
https://doi.org/10.1158/2159-8290.cd-22-1020
https://doi.org/10.1158/2159-8290.cd-22-1020
Autor:
Laura Crowley, Francesco Cambuli, Luis Aparicio, Maho Shibata, Brian D Robinson, Shouhong Xuan, Weiping Li, Hanina Hibshoosh, Massimo Loda, Raul Rabadan, Michael M Shen
Publikováno v:
eLife, Vol 9 (2020)
Understanding the cellular constituents of the prostate is essential for identifying the cell of origin for prostate adenocarcinoma. Here, we describe a comprehensive single-cell atlas of the adult mouse prostate epithelium, which displays extensive
Externí odkaz:
https://doaj.org/article/97b0855c03e5439a823cccdc26ab4c71