Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hanife Esengil"'
Autor:
Gregory D. Plowman, Casey Kopczynski, Kim Lickteig, Lori Friedman, Christopher G. Winter, Matt B. Mahoney, Kellie Whittaker, Helen Francis-Lang, Marcia Belvin, Matthew V. Lorenzi, Ferhad Ahmad, Hanife Esengil, Annette L. Parks, Brent A. Rupnow, Monique Nicoll, Feng Chen, Lynn M. Young, Mariano Tabios, Kyle A. Edgar, Christopher C. Park, Amanda Norton, Laleh Shayesteh, Pamela M. Carroll
Publikováno v:
Genetics. 170:161-171
Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65091c5d6b43aa177e96872e9a4ef058
https://doi.org/10.1534/genetics.104.036343
https://doi.org/10.1534/genetics.104.036343
Autor:
Hanife Esengil, James K. Chen
Publikováno v:
Molecular bioSystems. 4(4)
Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b92cebdb10e39ff83dcc9f5edbe8f
https://pubmed.ncbi.nlm.nih.gov/18354783
https://pubmed.ncbi.nlm.nih.gov/18354783
Autor:
Stanley Tiong, Daniel Curtis, Kari Huppert, Alexander C. Phan, Matt B. Mahoney, Runa Chatterjee, Annette L. Parks, Lynn L'Archeveque, William W. Fisher, Wendy Woo, Hanife Esengil, Christopher G. Winter, Panos Philandrinos, Felipa A. Mapa, David A. Ruddy, Michael C. Ellis
Presenilin is the enzymatic component of γ-secretase, a multisubunit intramembrane protease that processes several transmembrane receptors, such as the amyloid precursor protein (APP). Mutations in human Presenilins lead to altered APP cleavage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc83ef0b01d84d5af415df38a9fe652
https://europepmc.org/articles/PMC1456381/
https://europepmc.org/articles/PMC1456381/
Publikováno v:
Nature Chemical Biology. 3:154-155
The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48c553c3a5ba178f2a5a1cc8829295c
https://doi.org/10.1038/nchembio858
https://doi.org/10.1038/nchembio858